The cytotoxicity effects of spermidine sulphur analogues Type 1 (SSA-1) and Type 2 (SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cells (MCF-7)

The cytotoxicity effects of spermidine sulphur analogues Type 1 (SSA-1) and Type 2 (SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cells (MCF-7)

Introduction: Over accumulation of polyamines is one of the causes of cancer because polyamines could promote the cancer cells growth. Due to the lack of specificity and increased reports of side effects in the current cancer treatment, one of the strategies to overcome the challenges is by utilizin...

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Main Authors: Jamil, Masnizahani, Abdul Ghani, Radiah, Sahabudeen, Adzly Hairee, Fong, Fiona How Ni
Format: Conference or Workshop Item
Language:English
Published: 2017
Subjects:
QD Chemistry
RM300 Drugs and their action
Online Access:http://irep.iium.edu.my/58032/
http://irep.iium.edu.my/58032/20/58032.pdf
id iium-58032
recordtype eprints
spelling iium-580322017-08-18T07:51:30Z http://irep.iium.edu.my/58032/ The cytotoxicity effects of spermidine sulphur analogues Type 1 (SSA-1) and Type 2 (SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cells (MCF-7) Jamil, Masnizahani Abdul Ghani, Radiah Sahabudeen, Adzly Hairee Fong, Fiona How Ni QD Chemistry RM300 Drugs and their action Introduction: Over accumulation of polyamines is one of the causes of cancer because polyamines could promote the cancer cells growth. Due to the lack of specificity and increased reports of side effects in the current cancer treatment, one of the strategies to overcome the challenges is by utilizing polyamines as vectors of known cytotoxic compounds to target the cancer cells. Therefore, this study was aimed to investigate the cytotoxicity effects of Spermidine Sulphur Analogues Type 1 and Type 2 (SSA-1 and SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cell (MCF-7). Materials and method: The cytotoxicity studies of SSA-1 and SSA-2 against in vitro cells: A549, HCT-8, and MCF-7 were carried out by using MTT assay and the IC50 in each cell was determined. Results: SSA-1 exhibited cytotoxicity effects in all selected cell lines with IC50 between 2.0 mM to 5.3 mM. While SSA-2 also exhibited cytotoxicity effects in all cell lines with IC50 between 0.8 mM to 5.0 mM. Conclusion: SSA-1 and SSA-2 were cytotoxic against A549, HCT-8, and MCF-7. However, the cytotoxic effects were not potent against these cell lines as a higher concentration of compounds were needed to inhibit the cells growth. Hence, it is suggested that further study on the cytotoxicity effects of SSA-1 and SSA-2 in other cell lines should be conducted and the formulation of the analogues based on sulphur should be amended by conjugating it with selected metal. 2017 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/58032/20/58032.pdf Jamil, Masnizahani and Abdul Ghani, Radiah and Sahabudeen, Adzly Hairee and Fong, Fiona How Ni (2017) The cytotoxicity effects of spermidine sulphur analogues Type 1 (SSA-1) and Type 2 (SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cells (MCF-7). In: Medical Research Symposium 2017, 10th August 2017, Kuantan, Pahang Darul Makmur, Malaysia. (Unpublished)
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic QD Chemistry
RM300 Drugs and their action
spellingShingle QD Chemistry
RM300 Drugs and their action
Jamil, Masnizahani
Abdul Ghani, Radiah
Sahabudeen, Adzly Hairee
Fong, Fiona How Ni
The cytotoxicity effects of spermidine sulphur analogues Type 1 (SSA-1) and Type 2 (SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cells (MCF-7)
description Introduction: Over accumulation of polyamines is one of the causes of cancer because polyamines could promote the cancer cells growth. Due to the lack of specificity and increased reports of side effects in the current cancer treatment, one of the strategies to overcome the challenges is by utilizing polyamines as vectors of known cytotoxic compounds to target the cancer cells. Therefore, this study was aimed to investigate the cytotoxicity effects of Spermidine Sulphur Analogues Type 1 and Type 2 (SSA-1 and SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cell (MCF-7). Materials and method: The cytotoxicity studies of SSA-1 and SSA-2 against in vitro cells: A549, HCT-8, and MCF-7 were carried out by using MTT assay and the IC50 in each cell was determined. Results: SSA-1 exhibited cytotoxicity effects in all selected cell lines with IC50 between 2.0 mM to 5.3 mM. While SSA-2 also exhibited cytotoxicity effects in all cell lines with IC50 between 0.8 mM to 5.0 mM. Conclusion: SSA-1 and SSA-2 were cytotoxic against A549, HCT-8, and MCF-7. However, the cytotoxic effects were not potent against these cell lines as a higher concentration of compounds were needed to inhibit the cells growth. Hence, it is suggested that further study on the cytotoxicity effects of SSA-1 and SSA-2 in other cell lines should be conducted and the formulation of the analogues based on sulphur should be amended by conjugating it with selected metal.
format Conference or Workshop Item
author Jamil, Masnizahani
Abdul Ghani, Radiah
Sahabudeen, Adzly Hairee
Fong, Fiona How Ni
author_facet Jamil, Masnizahani
Abdul Ghani, Radiah
Sahabudeen, Adzly Hairee
Fong, Fiona How Ni
author_sort Jamil, Masnizahani
title The cytotoxicity effects of spermidine sulphur analogues Type 1 (SSA-1) and Type 2 (SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cells (MCF-7)
title_short The cytotoxicity effects of spermidine sulphur analogues Type 1 (SSA-1) and Type 2 (SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cells (MCF-7)
title_full The cytotoxicity effects of spermidine sulphur analogues Type 1 (SSA-1) and Type 2 (SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cells (MCF-7)
title_fullStr The cytotoxicity effects of spermidine sulphur analogues Type 1 (SSA-1) and Type 2 (SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cells (MCF-7)
title_full_unstemmed The cytotoxicity effects of spermidine sulphur analogues Type 1 (SSA-1) and Type 2 (SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cells (MCF-7)
title_sort cytotoxicity effects of spermidine sulphur analogues type 1 (ssa-1) and type 2 (ssa-2) against human lung adenocarcinoma cells (a549), human colorectal adenocarcinoma cells (hct-8), and human breast adenocarcinoma cells (mcf-7)
publishDate 2017
url http://irep.iium.edu.my/58032/
http://irep.iium.edu.my/58032/20/58032.pdf
first_indexed 2023-09-18T21:22:03Z
last_indexed 2023-09-18T21:22:03Z
_version_ 1777411946848452608

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