Comparison of biocompatibility and biodegradability of poly(lactic-co-glycolic acid) (PLGA) combined with autologous fibrin versus PLGA for intra-articular screw fixation; an in- vivo study with New Zealand white rabbits- the microradiograph outcome
The great potential of biodegradable polymers in orthopaedic surgery is gradually being recognized. PLGA is one of the common polymers used. However, long term outcomes, with regards to PLGA, are still not well documented. Hence, we attempted to study the outcome of PLGA and also its combination...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Kulliyyah of Medicine, International Islamic University Malaysia
2017
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/57889/ http://irep.iium.edu.my/57889/ http://irep.iium.edu.my/57889/1/Abstract-journal-for-IMJM-final-MRS%202017%20theenesh.pdf |
| Summary: | The great potential of biodegradable polymers in orthopaedic surgery is
gradually being recognized. PLGA is one of the common polymers used. However, long
term outcomes, with regards to PLGA, are still not well documented. Hence, we
attempted to study the outcome of PLGA and also its combination with fibrin.
Materials and method: Objectives : 1) To compare biocompatibility and biodegradability
of polymer (PLGA + fibrin) with PLGA for intra-articular screw fixation 2) to study the
imaging microradiograph) features. We used fabricated PLGA scaffolds in combination
with autologous fibrin for an in-vivo prospective research. Total of nine New Zealand
White Rabbits (NZWR) were operated and the scaffolds were placed at both medial and
lateral femoral condyles of the right knee and those with fibrin at the left knee. Post
implantation, evaluation was done at 6,12 and 24 weeks (three NZWR in each group).
For microradiological assessment, micro CT (Skyscan 1176) was used.
Results: The combination of PLGA and fibrin has better biocompatibility, showed faster
biodegradation and more quantitative integration of osseous tissues.
Conclusion: Biodegradable polymer PLGA with incorporation of fibrin resulted in superior
outcome compared to usage of other current biodegradable polymers. |
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