Mesoionic sydnone: a review in their chemical and biological properties

Various literature sources have documented sydnones as important molecules with exclusive chemical properties and a wide spectrum of bioactivities. Sydnone can be defined as a five-membered pseudo-aromatic heterocyclic molecule. Classically, 1,2,3-oxadiazole forms the main skeleton of sydnone. The m...

Full description

Bibliographic Details
Main Authors:	Abdualkader, Abdualrahman Mohammed, Bakhtiar, M. Taher, Nik Yusoff, Nik Mohd. Idris
Format:	Article
Language:	English
Published:	Innovare Academic Sciences 2017
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/57848/ http://irep.iium.edu.my/57848/ http://irep.iium.edu.my/57848/ http://irep.iium.edu.my/57848/1/IJPPS-Abduarahman.pdf

id	iium-57848
recordtype	eprints
spelling	iium-578482017-08-02T03:12:43Z http://irep.iium.edu.my/57848/ Mesoionic sydnone: a review in their chemical and biological properties Abdualkader, Abdualrahman Mohammed Bakhtiar, M. Taher Nik Yusoff, Nik Mohd. Idris RS Pharmacy and materia medica Various literature sources have documented sydnones as important molecules with exclusive chemical properties and a wide spectrum of bioactivities. Sydnone can be defined as a five-membered pseudo-aromatic heterocyclic molecule. Classically, 1,2,3-oxadiazole forms the main skeleton of sydnone. The molecule has delocalized balanced positive and negative charges. The five annular atoms share the positive charge and the enolate-like exocyclic oxygen atom bears the negative charge. The hydrogen atom at the position C4 was proved to have acidic and nucleophilic functionalities making the sydnone ring reactive towards electrophilic reagents. These unique chemical features enable sydnones to interact with biomolecules resulting in important therapeutic effects like anticancer, antidiabetic, antimicrobial, antioxidant and anti-inflammatory. Consequently, we aim from the current article to review the available chemical and pharmacological information on sydnone and its derivatives. Innovare Academic Sciences 2017-08-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/57848/1/IJPPS-Abduarahman.pdf Abdualkader, Abdualrahman Mohammed and Bakhtiar, M. Taher and Nik Yusoff, Nik Mohd. Idris (2017) Mesoionic sydnone: a review in their chemical and biological properties. International Journal of Pharmacy and Pharmaceutical Sciences, 9 (8). pp. 1-9. ISSN 0975-1491 https://innovareacademics.in/journals/index.php/ijpps/article/viewFile/18774/12085 10.22159/ijpps.2017v9i8.18774
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Abdualkader, Abdualrahman Mohammed Bakhtiar, M. Taher Nik Yusoff, Nik Mohd. Idris Mesoionic sydnone: a review in their chemical and biological properties
description	Various literature sources have documented sydnones as important molecules with exclusive chemical properties and a wide spectrum of bioactivities. Sydnone can be defined as a five-membered pseudo-aromatic heterocyclic molecule. Classically, 1,2,3-oxadiazole forms the main skeleton of sydnone. The molecule has delocalized balanced positive and negative charges. The five annular atoms share the positive charge and the enolate-like exocyclic oxygen atom bears the negative charge. The hydrogen atom at the position C4 was proved to have acidic and nucleophilic functionalities making the sydnone ring reactive towards electrophilic reagents. These unique chemical features enable sydnones to interact with biomolecules resulting in important therapeutic effects like anticancer, antidiabetic, antimicrobial, antioxidant and anti-inflammatory. Consequently, we aim from the current article to review the available chemical and pharmacological information on sydnone and its derivatives.
format	Article
author	Abdualkader, Abdualrahman Mohammed Bakhtiar, M. Taher Nik Yusoff, Nik Mohd. Idris
author_facet	Abdualkader, Abdualrahman Mohammed Bakhtiar, M. Taher Nik Yusoff, Nik Mohd. Idris
author_sort	Abdualkader, Abdualrahman Mohammed
title	Mesoionic sydnone: a review in their chemical and biological properties
title_short	Mesoionic sydnone: a review in their chemical and biological properties
title_full	Mesoionic sydnone: a review in their chemical and biological properties
title_fullStr	Mesoionic sydnone: a review in their chemical and biological properties
title_full_unstemmed	Mesoionic sydnone: a review in their chemical and biological properties
title_sort	mesoionic sydnone: a review in their chemical and biological properties
publisher	Innovare Academic Sciences
publishDate	2017
url	http://irep.iium.edu.my/57848/ http://irep.iium.edu.my/57848/ http://irep.iium.edu.my/57848/ http://irep.iium.edu.my/57848/1/IJPPS-Abduarahman.pdf
first_indexed	2023-09-18T21:21:46Z
last_indexed	2023-09-18T21:21:46Z
_version_	1777411929575260160

Mesoionic sydnone: a review in their chemical and biological properties

Similar Items