Baccaurea angulata fruit juice ameliorates altered hematological and biochemical biomarkers in diet-induced hypercholesterolemic rabbits

Hypercholesterolemia is an important risk factor linked to the alteration of blood hematology and clinical chemistry associated with the development and progression of atherosclerosis. Previous studies have demonstrated the safety and potential health benefits of Baccaurea angulata (BA) fruit. We...

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Main Authors:	Ahmed, Idris Adewale, Abimbola Mikail, Maryam, Ibrahim, Muhammad
Format:	Article
Language:	English English
Published:	Elsevier Inc. 2017
Subjects:	RM214 Diet therapy. Diet and dietectics in disease
Online Access:	http://irep.iium.edu.my/57820/ http://irep.iium.edu.my/57820/ http://irep.iium.edu.my/57820/ http://irep.iium.edu.my/57820/7/57820-Baccaurea%20angulata%20fruit%20jiuce%20ameliorates%20altered.pdf http://irep.iium.edu.my/57820/13/57820_Baccaurea%20angulata%20fruit%20juice%20ameliorates_scopus.pdf

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spelling	iium-578202018-04-05T02:47:22Z http://irep.iium.edu.my/57820/ Baccaurea angulata fruit juice ameliorates altered hematological and biochemical biomarkers in diet-induced hypercholesterolemic rabbits Ahmed, Idris Adewale Abimbola Mikail, Maryam Ibrahim, Muhammad RM214 Diet therapy. Diet and dietectics in disease Hypercholesterolemia is an important risk factor linked to the alteration of blood hematology and clinical chemistry associated with the development and progression of atherosclerosis. Previous studies have demonstrated the safety and potential health benefits of Baccaurea angulata (BA) fruit. We hypothesized that the oral administration of BA fruit juice could ameliorate the alteration in the hematological and biochemical biomarkers of diet-induced hypercholesterolemic rabbits. The aim of this study was to investigate the effects of different doses of BA juice on the hematological and biochemical biomarkers in normo- and hypercholesterolemic rabbits. Thirty-five healthy adult New Zealand White rabbits were assigned to seven different groups for 90 days of diet intervention. Four atherogenic groups were fed a 1% cholesterol diet and 0, 0.5, 1.0, and 1.5 mL of BA juice per kg of rabbit daily. The other three normal groups were fed a commercial rabbit pellet diet and 0, 0.5, and 1.0 mLof BA juice per kg of rabbit daily. Baseline and final blood samples after 90 days of repeated administration BA juice were analyzed for hematological parameters while serum, aortic and hepatic lysates were analyzed for lipid profiles and other biochemical biomarkers. The alteration of the hemopoietic system, physiological changes in serumand tissues lipid profiles and other biochemicals resulting from the consumption of a high-cholesterol diet were significantly (P < .05) ameliorated by the administration of BA juice. Improvements of the biomarkers in rabbits were dose-dependent, markedly enhanced at the highest dose of juice (1.5 mL/kg/day). The results suggest potential health benefits of the antioxidant-rich BA fruit juice against hypercholesterolemia-associated hematological and biochemical alterations in the rabbit. Elsevier Inc. 2017-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/57820/7/57820-Baccaurea%20angulata%20fruit%20jiuce%20ameliorates%20altered.pdf application/pdf en http://irep.iium.edu.my/57820/13/57820_Baccaurea%20angulata%20fruit%20juice%20ameliorates_scopus.pdf Ahmed, Idris Adewale and Abimbola Mikail, Maryam and Ibrahim, Muhammad (2017) Baccaurea angulata fruit juice ameliorates altered hematological and biochemical biomarkers in diet-induced hypercholesterolemic rabbits. Nutrition Research, 42. pp. 31-42. ISSN 0271-5317 E-ISSN 1879-0739 http://www.sciencedirect.com/science/article/pii/S0271531716305127 10.1016/j.nutres.2017.04.012
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RM214 Diet therapy. Diet and dietectics in disease
spellingShingle	RM214 Diet therapy. Diet and dietectics in disease Ahmed, Idris Adewale Abimbola Mikail, Maryam Ibrahim, Muhammad Baccaurea angulata fruit juice ameliorates altered hematological and biochemical biomarkers in diet-induced hypercholesterolemic rabbits
description	Hypercholesterolemia is an important risk factor linked to the alteration of blood hematology and clinical chemistry associated with the development and progression of atherosclerosis. Previous studies have demonstrated the safety and potential health benefits of Baccaurea angulata (BA) fruit. We hypothesized that the oral administration of BA fruit juice could ameliorate the alteration in the hematological and biochemical biomarkers of diet-induced hypercholesterolemic rabbits. The aim of this study was to investigate the effects of different doses of BA juice on the hematological and biochemical biomarkers in normo- and hypercholesterolemic rabbits. Thirty-five healthy adult New Zealand White rabbits were assigned to seven different groups for 90 days of diet intervention. Four atherogenic groups were fed a 1% cholesterol diet and 0, 0.5, 1.0, and 1.5 mL of BA juice per kg of rabbit daily. The other three normal groups were fed a commercial rabbit pellet diet and 0, 0.5, and 1.0 mLof BA juice per kg of rabbit daily. Baseline and final blood samples after 90 days of repeated administration BA juice were analyzed for hematological parameters while serum, aortic and hepatic lysates were analyzed for lipid profiles and other biochemical biomarkers. The alteration of the hemopoietic system, physiological changes in serumand tissues lipid profiles and other biochemicals resulting from the consumption of a high-cholesterol diet were significantly (P < .05) ameliorated by the administration of BA juice. Improvements of the biomarkers in rabbits were dose-dependent, markedly enhanced at the highest dose of juice (1.5 mL/kg/day). The results suggest potential health benefits of the antioxidant-rich BA fruit juice against hypercholesterolemia-associated hematological and biochemical alterations in the rabbit.
format	Article
author	Ahmed, Idris Adewale Abimbola Mikail, Maryam Ibrahim, Muhammad
author_facet	Ahmed, Idris Adewale Abimbola Mikail, Maryam Ibrahim, Muhammad
author_sort	Ahmed, Idris Adewale
title	Baccaurea angulata fruit juice ameliorates altered hematological and biochemical biomarkers in diet-induced hypercholesterolemic rabbits
title_short	Baccaurea angulata fruit juice ameliorates altered hematological and biochemical biomarkers in diet-induced hypercholesterolemic rabbits
title_full	Baccaurea angulata fruit juice ameliorates altered hematological and biochemical biomarkers in diet-induced hypercholesterolemic rabbits
title_fullStr	Baccaurea angulata fruit juice ameliorates altered hematological and biochemical biomarkers in diet-induced hypercholesterolemic rabbits
title_full_unstemmed	Baccaurea angulata fruit juice ameliorates altered hematological and biochemical biomarkers in diet-induced hypercholesterolemic rabbits
title_sort	baccaurea angulata fruit juice ameliorates altered hematological and biochemical biomarkers in diet-induced hypercholesterolemic rabbits
publisher	Elsevier Inc.
publishDate	2017
url	http://irep.iium.edu.my/57820/ http://irep.iium.edu.my/57820/ http://irep.iium.edu.my/57820/ http://irep.iium.edu.my/57820/7/57820-Baccaurea%20angulata%20fruit%20jiuce%20ameliorates%20altered.pdf http://irep.iium.edu.my/57820/13/57820_Baccaurea%20angulata%20fruit%20juice%20ameliorates_scopus.pdf
first_indexed	2023-09-18T21:21:44Z
last_indexed	2023-09-18T21:21:44Z
_version_	1777411927547314176

Baccaurea angulata fruit juice ameliorates altered hematological and biochemical biomarkers in diet-induced hypercholesterolemic rabbits

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