Baccaurea angulata fruit juice reduces atherosclerotic lesions in diet-induced Hypercholesterolemic rabbits
Background: Atherosclerosis is the most common disease of large and medium-sized arteries linked to oxidative stress, dyslipidemia as well as chronic inflammation. The aim of this study was to evaluate the potential health benefits of Baccaurea angulata (BA) fruit juice on the aorta of diet-induced...
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BioMed Central Ltd.
2017
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eprints |
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iium-578162018-04-05T03:00:15Z http://irep.iium.edu.my/57816/ Baccaurea angulata fruit juice reduces atherosclerotic lesions in diet-induced Hypercholesterolemic rabbits Ibrahim, Muhammad Ahmed, Idris Adewale Abimbola, Maryam Mikail Ishola, Afeez Adekunle Draman, Samsul Md Isa, Muhammad Lokman Mat Yusof, Afzan RM214 Diet therapy. Diet and dietectics in disease Background: Atherosclerosis is the most common disease of large and medium-sized arteries linked to oxidative stress, dyslipidemia as well as chronic inflammation. The aim of this study was to evaluate the potential health benefits of Baccaurea angulata (BA) fruit juice on the aorta of diet-induced hypercholesterolemic rabbits, to detect an accumulation of fatty streak and evaluate the percentage of atherosclerotic lesion accrued. Methods: Thirty-five healthy male adults New Zealand White rabbits were assigned to seven different groups. Four groups were fed 1% cholesterol diet and 0, 0.5, 1.0, and 1.5 mL of BA fruit juice per kg of rabbit daily (atherogenic groups), while the other three groups were fed commercial rabbit pellet and 0, 0.5, and 1.0 mL of juice per kg of rabbit daily (normocholesterolemic groups) for 90 days. The thoracic and abdominal aorta between the heart origin and bifurcation into iliac arteries of all the rabbits were carefully removed and analyzed accordingly. Results: The supplementation of the high-cholesterol diet of hypercholesterolemic rabbits with only 0.5 mL BA/kg rabbit per day significantly (p < 0.001) improved aortic lipid profile, attenuated aortic fatty streak development and reduced intima thickening. Higher BA doses used (1.0 and 1.5 mL/kg rabbit per day) also significantly (p < 0.001) decreased further the development of aortic fatty streaks, reduced the thickening of the tunica intima layer and preserved endothelial healing following arterial injury. Conclusion: Therefore, BA fruit is a potential novel functional food with effective anti-inflammatory, antiatherogenic and hypocholesterolemic activities. BioMed Central Ltd. 2017-07-07 Article PeerReviewed application/pdf en http://irep.iium.edu.my/57816/1/Baccaurea%20angulata%20fruit%20juice%20reduces.pdf application/pdf en http://irep.iium.edu.my/57816/7/57816-Baccaurea%20angulata%20fruit%20juice_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/57816/8/57816-Baccaurea%20angulata%20fruit%20juice_WOS.pdf Ibrahim, Muhammad and Ahmed, Idris Adewale and Abimbola, Maryam Mikail and Ishola, Afeez Adekunle and Draman, Samsul and Md Isa, Muhammad Lokman and Mat Yusof, Afzan (2017) Baccaurea angulata fruit juice reduces atherosclerotic lesions in diet-induced Hypercholesterolemic rabbits. Lipids in Health and Disease, 16. pp. 1-8. ISSN 1476-511X https://lipidworld.biomedcentral.com/track/pdf/10.1186/s12944-017-0526-2?site=lipidworld.biomedcentral.com 10.1186/s12944-017-0526-2 |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English English English |
| topic |
RM214 Diet therapy. Diet and dietectics in disease |
| spellingShingle |
RM214 Diet therapy. Diet and dietectics in disease Ibrahim, Muhammad Ahmed, Idris Adewale Abimbola, Maryam Mikail Ishola, Afeez Adekunle Draman, Samsul Md Isa, Muhammad Lokman Mat Yusof, Afzan Baccaurea angulata fruit juice reduces atherosclerotic lesions in diet-induced Hypercholesterolemic rabbits |
| description |
Background: Atherosclerosis is the most common disease of large and medium-sized arteries linked to oxidative stress, dyslipidemia as well as chronic inflammation. The aim of this study was to evaluate the potential health benefits of Baccaurea angulata (BA) fruit juice on the aorta of diet-induced hypercholesterolemic rabbits, to detect an accumulation of fatty streak and evaluate the percentage of atherosclerotic lesion accrued.
Methods: Thirty-five healthy male adults New Zealand White rabbits were assigned to seven different groups. Four groups were fed 1% cholesterol diet and 0, 0.5, 1.0, and 1.5 mL of BA fruit juice per kg of rabbit daily (atherogenic groups), while the other three groups were fed commercial rabbit pellet and 0, 0.5, and 1.0 mL of juice per kg of rabbit daily (normocholesterolemic groups) for 90 days. The thoracic and abdominal aorta between the heart origin and bifurcation into iliac arteries of all the rabbits were carefully removed and analyzed accordingly.
Results: The supplementation of the high-cholesterol diet of hypercholesterolemic rabbits with only 0.5 mL BA/kg rabbit per day significantly (p < 0.001) improved aortic lipid profile, attenuated aortic fatty streak development and reduced intima thickening. Higher BA doses used (1.0 and 1.5 mL/kg rabbit per day) also significantly (p < 0.001) decreased further the development of aortic fatty streaks, reduced the thickening of the tunica intima layer and preserved endothelial healing following arterial injury.
Conclusion: Therefore, BA fruit is a potential novel functional food with effective anti-inflammatory, antiatherogenic and hypocholesterolemic activities. |
| format |
Article |
| author |
Ibrahim, Muhammad Ahmed, Idris Adewale Abimbola, Maryam Mikail Ishola, Afeez Adekunle Draman, Samsul Md Isa, Muhammad Lokman Mat Yusof, Afzan |
| author_facet |
Ibrahim, Muhammad Ahmed, Idris Adewale Abimbola, Maryam Mikail Ishola, Afeez Adekunle Draman, Samsul Md Isa, Muhammad Lokman Mat Yusof, Afzan |
| author_sort |
Ibrahim, Muhammad |
| title |
Baccaurea angulata fruit juice reduces atherosclerotic lesions in diet-induced Hypercholesterolemic rabbits |
| title_short |
Baccaurea angulata fruit juice reduces atherosclerotic lesions in diet-induced Hypercholesterolemic rabbits |
| title_full |
Baccaurea angulata fruit juice reduces atherosclerotic lesions in diet-induced Hypercholesterolemic rabbits |
| title_fullStr |
Baccaurea angulata fruit juice reduces atherosclerotic lesions in diet-induced Hypercholesterolemic rabbits |
| title_full_unstemmed |
Baccaurea angulata fruit juice reduces atherosclerotic lesions in diet-induced Hypercholesterolemic rabbits |
| title_sort |
baccaurea angulata fruit juice reduces atherosclerotic lesions in diet-induced hypercholesterolemic rabbits |
| publisher |
BioMed Central Ltd. |
| publishDate |
2017 |
| url |
http://irep.iium.edu.my/57816/ http://irep.iium.edu.my/57816/ http://irep.iium.edu.my/57816/ http://irep.iium.edu.my/57816/1/Baccaurea%20angulata%20fruit%20juice%20reduces.pdf http://irep.iium.edu.my/57816/7/57816-Baccaurea%20angulata%20fruit%20juice_SCOPUS.pdf http://irep.iium.edu.my/57816/8/57816-Baccaurea%20angulata%20fruit%20juice_WOS.pdf |
| first_indexed |
2023-09-18T21:21:44Z |
| last_indexed |
2023-09-18T21:21:44Z |
| _version_ |
1777411927129980928 |