Palm olein emulsion: a novel vehicle for topical drug delivery of betamethasone 17-valerate

This study aims to investigate the use of palm olein as the oil phase for betamethasone 17-valerate (BV) emulsions. The physicochemical properties of the formulations were characterized. In vitro drug release study was performed with the Hanson Vertical Diffusion Cell System; the samples were quant...

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Main Authors:	Ahmad, Kausar, Win, Thazin, Md. Jaffri, Juliana, Edueng, Khadijah, Bakhtiar, M. Taher
Format:	Article
Language:	English English English
Published:	American Association of Pharmaceutical Scientist 2018
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/57772/ http://irep.iium.edu.my/57772/ http://irep.iium.edu.my/57772/ http://irep.iium.edu.my/57772/1/AAPScitech.pdf http://irep.iium.edu.my/57772/7/57772_Palm%20olein%20emulsion_SCOPUS.pdf http://irep.iium.edu.my/57772/8/57772_Palm%20olein%20emulsion_WOS.pdf

id	iium-57772
recordtype	eprints
spelling	iium-577722018-05-24T01:27:24Z http://irep.iium.edu.my/57772/ Palm olein emulsion: a novel vehicle for topical drug delivery of betamethasone 17-valerate Ahmad, Kausar Win, Thazin Md. Jaffri, Juliana Edueng, Khadijah Bakhtiar, M. Taher RS Pharmacy and materia medica This study aims to investigate the use of palm olein as the oil phase for betamethasone 17-valerate (BV) emulsions. The physicochemical properties of the formulations were characterized. In vitro drug release study was performed with the Hanson Vertical Diffusion Cell System; the samples were quantified with HPLC and the results were compared with commercial products. Optimized emulsion formulations were subjected to stability studies for 3 months at temperatures of 4, 25, and 40°C; the betamethasone 17- valerate content was analyzed using HPLC. The formulations produced mean particle size of 2–4 μm, viscosities of 50–250 mPa.s, and zeta potential between −45 and −68 mV. The rheological analyses showed that the emulsions exhibited pseudoplastic and viscoelastic behavior. The in vitro release of BV from palm olein emulsion through cellulose acetate was 4.5 times higher than that of commercial products and more BV molecules deposited in rat skin. Less than 4% of the drug was degraded in the formulations during the 3-month period when they were subjected to the three different temperatures. These findings indicate that palm olein-in-water emulsion can be an alternative vehicle for topical drug delivery system with superior permeability. American Association of Pharmaceutical Scientist 2018-01-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/57772/1/AAPScitech.pdf application/pdf en http://irep.iium.edu.my/57772/7/57772_Palm%20olein%20emulsion_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/57772/8/57772_Palm%20olein%20emulsion_WOS.pdf Ahmad, Kausar and Win, Thazin and Md. Jaffri, Juliana and Edueng, Khadijah and Bakhtiar, M. Taher (2018) Palm olein emulsion: a novel vehicle for topical drug delivery of betamethasone 17-valerate. AAPS PharmSciTech, 19 (1). pp. 371-383. ISSN 1530-9932 https://link.springer.com/article/10.1208%2Fs12249-017-0843-9 10.1208/s12249-017-0843-9
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Ahmad, Kausar Win, Thazin Md. Jaffri, Juliana Edueng, Khadijah Bakhtiar, M. Taher Palm olein emulsion: a novel vehicle for topical drug delivery of betamethasone 17-valerate
description	This study aims to investigate the use of palm olein as the oil phase for betamethasone 17-valerate (BV) emulsions. The physicochemical properties of the formulations were characterized. In vitro drug release study was performed with the Hanson Vertical Diffusion Cell System; the samples were quantified with HPLC and the results were compared with commercial products. Optimized emulsion formulations were subjected to stability studies for 3 months at temperatures of 4, 25, and 40°C; the betamethasone 17- valerate content was analyzed using HPLC. The formulations produced mean particle size of 2–4 μm, viscosities of 50–250 mPa.s, and zeta potential between −45 and −68 mV. The rheological analyses showed that the emulsions exhibited pseudoplastic and viscoelastic behavior. The in vitro release of BV from palm olein emulsion through cellulose acetate was 4.5 times higher than that of commercial products and more BV molecules deposited in rat skin. Less than 4% of the drug was degraded in the formulations during the 3-month period when they were subjected to the three different temperatures. These findings indicate that palm olein-in-water emulsion can be an alternative vehicle for topical drug delivery system with superior permeability.
format	Article
author	Ahmad, Kausar Win, Thazin Md. Jaffri, Juliana Edueng, Khadijah Bakhtiar, M. Taher
author_facet	Ahmad, Kausar Win, Thazin Md. Jaffri, Juliana Edueng, Khadijah Bakhtiar, M. Taher
author_sort	Ahmad, Kausar
title	Palm olein emulsion: a novel vehicle for topical drug delivery of betamethasone 17-valerate
title_short	Palm olein emulsion: a novel vehicle for topical drug delivery of betamethasone 17-valerate
title_full	Palm olein emulsion: a novel vehicle for topical drug delivery of betamethasone 17-valerate
title_fullStr	Palm olein emulsion: a novel vehicle for topical drug delivery of betamethasone 17-valerate
title_full_unstemmed	Palm olein emulsion: a novel vehicle for topical drug delivery of betamethasone 17-valerate
title_sort	palm olein emulsion: a novel vehicle for topical drug delivery of betamethasone 17-valerate
publisher	American Association of Pharmaceutical Scientist
publishDate	2018
url	http://irep.iium.edu.my/57772/ http://irep.iium.edu.my/57772/ http://irep.iium.edu.my/57772/ http://irep.iium.edu.my/57772/1/AAPScitech.pdf http://irep.iium.edu.my/57772/7/57772_Palm%20olein%20emulsion_SCOPUS.pdf http://irep.iium.edu.my/57772/8/57772_Palm%20olein%20emulsion_WOS.pdf
first_indexed	2023-09-18T21:21:40Z
last_indexed	2023-09-18T21:21:40Z
_version_	1777411923315261440

Palm olein emulsion: a novel vehicle for topical drug delivery of betamethasone 17-valerate

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