Acute toxicity of Trigonella foenum-graecum (Fenugreek) seeds aqueous extracton liver in male mice, histopathological study

Acute toxic effect of fenugreek on liver histology has not been fully explored. Hence the objective of this study is to investigate the acute toxicity of fenugreek seeds aqueous extract (FSA) on liver histology. Twelve male Swiss albino mice, were randomly divided into control (C), and three treatm...

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Main Authors:	Hamad Alfarisi, Hamad Abdulsalam, Allow, Ahmed Kaid Naji, Hamdan, Asmah Hanim, Hamad Mohamed, Zenab
Format:	Article
Language:	English
Published:	Moksha Publishing House 2017
Subjects:	RM300 Drugs and their action
Online Access:	http://irep.iium.edu.my/57703/ http://irep.iium.edu.my/57703/ http://irep.iium.edu.my/57703/ http://irep.iium.edu.my/57703/1/ACUTE%20TOXICITY%20OF%20TRIGONELLA%20FOENUM-GRAECUM%20%28FENUGREEK%29%20SEEDS%20AQUEOUS%20EXTRACT%20My%20first%20published%20paper%20IRJP%202017%20%281%29.pdf

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spelling	iium-577032018-01-12T11:31:56Z http://irep.iium.edu.my/57703/ Acute toxicity of Trigonella foenum-graecum (Fenugreek) seeds aqueous extracton liver in male mice, histopathological study Hamad Alfarisi, Hamad Abdulsalam Allow, Ahmed Kaid Naji Hamdan, Asmah Hanim Hamad Mohamed, Zenab RM300 Drugs and their action Acute toxic effect of fenugreek on liver histology has not been fully explored. Hence the objective of this study is to investigate the acute toxicity of fenugreek seeds aqueous extract (FSA) on liver histology. Twelve male Swiss albino mice, were randomly divided into control (C), and three treatment (T1, T2, and T3) groups (n = 3 each). T1, T2, and T3 were given 3g, 6g, and 9g/kg body weight FSA respectively. Intragastric divided doses of FSA were given as per OECD guidelines 425. Continuous observation of signs of acute toxicity and survival set up. The mice were euthanized on day 14 and the liver was dissected and processed for histopathological examination. 3, 6, and 9g/kg body weight FSA doses failed to induce any of signs of acute toxicity. Histopathological examination revealed that, all FSA administered doses showed mild portal inflammation, mild mononuclear cell infiltration in hepatic parenchyma, in addition to mild bile stasis induced only in mice received 9g/kg of FSA. Administered doses of FSA showed mild liver histopathological inflammatory changes. Moksha Publishing House 2017-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/57703/1/ACUTE%20TOXICITY%20OF%20TRIGONELLA%20FOENUM-GRAECUM%20%28FENUGREEK%29%20SEEDS%20AQUEOUS%20EXTRACT%20My%20first%20published%20paper%20IRJP%202017%20%281%29.pdf Hamad Alfarisi, Hamad Abdulsalam and Allow, Ahmed Kaid Naji and Hamdan, Asmah Hanim and Hamad Mohamed, Zenab (2017) Acute toxicity of Trigonella foenum-graecum (Fenugreek) seeds aqueous extracton liver in male mice, histopathological study. International Research Journal Of Pharmacy, 8 (4). pp. 24-27. ISSN 2230-8407 http://www.irjponline.com/admin/php/uploads/2648_pdf.pdf 10.7897/2230-8407.080443
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RM300 Drugs and their action
spellingShingle	RM300 Drugs and their action Hamad Alfarisi, Hamad Abdulsalam Allow, Ahmed Kaid Naji Hamdan, Asmah Hanim Hamad Mohamed, Zenab Acute toxicity of Trigonella foenum-graecum (Fenugreek) seeds aqueous extracton liver in male mice, histopathological study
description	Acute toxic effect of fenugreek on liver histology has not been fully explored. Hence the objective of this study is to investigate the acute toxicity of fenugreek seeds aqueous extract (FSA) on liver histology. Twelve male Swiss albino mice, were randomly divided into control (C), and three treatment (T1, T2, and T3) groups (n = 3 each). T1, T2, and T3 were given 3g, 6g, and 9g/kg body weight FSA respectively. Intragastric divided doses of FSA were given as per OECD guidelines 425. Continuous observation of signs of acute toxicity and survival set up. The mice were euthanized on day 14 and the liver was dissected and processed for histopathological examination. 3, 6, and 9g/kg body weight FSA doses failed to induce any of signs of acute toxicity. Histopathological examination revealed that, all FSA administered doses showed mild portal inflammation, mild mononuclear cell infiltration in hepatic parenchyma, in addition to mild bile stasis induced only in mice received 9g/kg of FSA. Administered doses of FSA showed mild liver histopathological inflammatory changes.
format	Article
author	Hamad Alfarisi, Hamad Abdulsalam Allow, Ahmed Kaid Naji Hamdan, Asmah Hanim Hamad Mohamed, Zenab
author_facet	Hamad Alfarisi, Hamad Abdulsalam Allow, Ahmed Kaid Naji Hamdan, Asmah Hanim Hamad Mohamed, Zenab
author_sort	Hamad Alfarisi, Hamad Abdulsalam
title	Acute toxicity of Trigonella foenum-graecum (Fenugreek) seeds aqueous extracton liver in male mice, histopathological study
title_short	Acute toxicity of Trigonella foenum-graecum (Fenugreek) seeds aqueous extracton liver in male mice, histopathological study
title_full	Acute toxicity of Trigonella foenum-graecum (Fenugreek) seeds aqueous extracton liver in male mice, histopathological study
title_fullStr	Acute toxicity of Trigonella foenum-graecum (Fenugreek) seeds aqueous extracton liver in male mice, histopathological study
title_full_unstemmed	Acute toxicity of Trigonella foenum-graecum (Fenugreek) seeds aqueous extracton liver in male mice, histopathological study
title_sort	acute toxicity of trigonella foenum-graecum (fenugreek) seeds aqueous extracton liver in male mice, histopathological study
publisher	Moksha Publishing House
publishDate	2017
url	http://irep.iium.edu.my/57703/ http://irep.iium.edu.my/57703/ http://irep.iium.edu.my/57703/ http://irep.iium.edu.my/57703/1/ACUTE%20TOXICITY%20OF%20TRIGONELLA%20FOENUM-GRAECUM%20%28FENUGREEK%29%20SEEDS%20AQUEOUS%20EXTRACT%20My%20first%20published%20paper%20IRJP%202017%20%281%29.pdf
first_indexed	2023-09-18T21:21:35Z
last_indexed	2023-09-18T21:21:35Z
_version_	1777411917782974464

Acute toxicity of Trigonella foenum-graecum (Fenugreek) seeds aqueous extracton liver in male mice, histopathological study

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