The influence of the electrode dimension on the detection sensitivity of electric cell–substrate impedance sensing (ECIS) and its mathematical modeling

Detection sensitivity is a crucial criterion in the design and application of ECIS sensors. The influence of sensing electrode dimension on detection sensitivity is investigated in this paper. Eight types of ECIS sensors were fabricated, and their experimental results reveal that smaller-radius work...

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Main Authors:	Zhang, Xudong, Wang, William, Nordin, Anis Nurashikin, Li, Fang, Jang, Sunghoon, Voiculescu, Ioana R.
Format:	Article
Language:	English English
Published:	Elsevier B.V. 2017
Subjects:	QA Mathematics QA75 Electronic computers. Computer science
Online Access:	http://irep.iium.edu.my/57338/ http://irep.iium.edu.my/57338/ http://irep.iium.edu.my/57338/ http://irep.iium.edu.my/57338/1/57338_The%20influence%20of%20the%20electrode_article.pdf http://irep.iium.edu.my/57338/2/57338_The%20influence%20of%20the%20electrode_article_SCOPUS.pdf

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recordtype	eprints
spelling	iium-573382018-10-25T06:07:38Z http://irep.iium.edu.my/57338/ The influence of the electrode dimension on the detection sensitivity of electric cell–substrate impedance sensing (ECIS) and its mathematical modeling Zhang, Xudong Wang, William Nordin, Anis Nurashikin Li, Fang Jang, Sunghoon Voiculescu, Ioana R. QA Mathematics QA75 Electronic computers. Computer science Detection sensitivity is a crucial criterion in the design and application of ECIS sensors. The influence of sensing electrode dimension on detection sensitivity is investigated in this paper. Eight types of ECIS sensors were fabricated, and their experimental results reveal that smaller-radius working electrodes generate more sensitive impedance shift to cell density change. Also, the smaller radius of working electrodes yield higher impedance values, which improves signal-to-noise ratio. In a range from 1.0 mm to 3.5 mm, the distance between the working and counter electrodes does not affect impedance measurements. However, the distance should be large enough to prevent the current from directly bypassing the cells between the electrodes. A mathematical model has been developed to analyze the distribution of electric potential and current over the sensing electrodes of ECIS sensors, which is helpful in understanding the mechanisms of ECIS. This mathematical model, supported by experimental data and finite element analysis, is able to illustrate a quantitative relationship between cell impedance and cell characteristics. This model can be used to optimize the design of ECIS sensors and interpret cell behavior. Elsevier B.V. 2017-08-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/57338/1/57338_The%20influence%20of%20the%20electrode_article.pdf application/pdf en http://irep.iium.edu.my/57338/2/57338_The%20influence%20of%20the%20electrode_article_SCOPUS.pdf Zhang, Xudong and Wang, William and Nordin, Anis Nurashikin and Li, Fang and Jang, Sunghoon and Voiculescu, Ioana R. (2017) The influence of the electrode dimension on the detection sensitivity of electric cell–substrate impedance sensing (ECIS) and its mathematical modeling. Sensors and Actuators, B: Chemical, 247. pp. 780-790. ISSN 0925-4005 http://www.sciencedirect.com/science/article/pii/S0925400517304641 10.1016/j.snb.2017.03.047
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QA Mathematics QA75 Electronic computers. Computer science
spellingShingle	QA Mathematics QA75 Electronic computers. Computer science Zhang, Xudong Wang, William Nordin, Anis Nurashikin Li, Fang Jang, Sunghoon Voiculescu, Ioana R. The influence of the electrode dimension on the detection sensitivity of electric cell–substrate impedance sensing (ECIS) and its mathematical modeling
description	Detection sensitivity is a crucial criterion in the design and application of ECIS sensors. The influence of sensing electrode dimension on detection sensitivity is investigated in this paper. Eight types of ECIS sensors were fabricated, and their experimental results reveal that smaller-radius working electrodes generate more sensitive impedance shift to cell density change. Also, the smaller radius of working electrodes yield higher impedance values, which improves signal-to-noise ratio. In a range from 1.0 mm to 3.5 mm, the distance between the working and counter electrodes does not affect impedance measurements. However, the distance should be large enough to prevent the current from directly bypassing the cells between the electrodes. A mathematical model has been developed to analyze the distribution of electric potential and current over the sensing electrodes of ECIS sensors, which is helpful in understanding the mechanisms of ECIS. This mathematical model, supported by experimental data and finite element analysis, is able to illustrate a quantitative relationship between cell impedance and cell characteristics. This model can be used to optimize the design of ECIS sensors and interpret cell behavior.
format	Article
author	Zhang, Xudong Wang, William Nordin, Anis Nurashikin Li, Fang Jang, Sunghoon Voiculescu, Ioana R.
author_facet	Zhang, Xudong Wang, William Nordin, Anis Nurashikin Li, Fang Jang, Sunghoon Voiculescu, Ioana R.
author_sort	Zhang, Xudong
title	The influence of the electrode dimension on the detection sensitivity of electric cell–substrate impedance sensing (ECIS) and its mathematical modeling
title_short	The influence of the electrode dimension on the detection sensitivity of electric cell–substrate impedance sensing (ECIS) and its mathematical modeling
title_full	The influence of the electrode dimension on the detection sensitivity of electric cell–substrate impedance sensing (ECIS) and its mathematical modeling
title_fullStr	The influence of the electrode dimension on the detection sensitivity of electric cell–substrate impedance sensing (ECIS) and its mathematical modeling
title_full_unstemmed	The influence of the electrode dimension on the detection sensitivity of electric cell–substrate impedance sensing (ECIS) and its mathematical modeling
title_sort	influence of the electrode dimension on the detection sensitivity of electric cell–substrate impedance sensing (ecis) and its mathematical modeling
publisher	Elsevier B.V.
publishDate	2017
url	http://irep.iium.edu.my/57338/ http://irep.iium.edu.my/57338/ http://irep.iium.edu.my/57338/ http://irep.iium.edu.my/57338/1/57338_The%20influence%20of%20the%20electrode_article.pdf http://irep.iium.edu.my/57338/2/57338_The%20influence%20of%20the%20electrode_article_SCOPUS.pdf
first_indexed	2023-09-18T21:21:02Z
last_indexed	2023-09-18T21:21:02Z
_version_	1777411883028971520

The influence of the electrode dimension on the detection sensitivity of electric cell–substrate impedance sensing (ECIS) and its mathematical modeling

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