Enhancement of the immediate release of paracetamol from alginate beads
Objective: Alginate beads are not soluble in the acid leading to small portion released in the stomach. This may not be favourable for drugs administered for fast action like paracetamol. So, this study was aimed to increase the immediate release of paracetamol from alginate beads, i.e. the releas...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Innovare Academic Sciences Pvt Ltd
2017
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/57264/ http://irep.iium.edu.my/57264/ http://irep.iium.edu.my/57264/ http://irep.iium.edu.my/57264/1/Enhancement%20of%20the%20immediate%20release%20of%20paracetamol%20from%20alginate%20beads.pdf http://irep.iium.edu.my/57264/7/57264_Enhancement%20of%20the%20immediate%20release_Scopus.pdf |
| Summary: | Objective: Alginate beads are not soluble in the acid leading to small portion released in the stomach. This may not be favourable for drugs
administered for fast action like paracetamol. So, this study was aimed to increase the immediate release of paracetamol from alginate beads, i.e. the
release in the acidic pH.
Methods: The beads were prepared by dropwise paracetamol/alginate suspension in divalent cation solution. Two attempts were used to increase
the dissolution of paracetamol in the acidic pH. First attempt was by only changing preparation variables: needle size, alginate viscosity and drug
loading using 23 full factorial design. The second approach was by adding excipients like carbopol, tween and polyethylene glycol. The beads were
characterized for their size, encapsulation efficiency and release profile.
Results: First approach, changing preparation variables without excipient adding, helped to increase the drug release in the acid but to a maximum
of 26% using a smaller needle, lower drug loading and higher alginate viscosity. However, optimising the formulation with suitable excipients
increased the drug release in the acid to 77.3%. The optimised formulation included carbopol 940 (pH sensitive polymer) and tween 80 (facilitates
water entry) in the beads, with using barium chloride instead of calcium chloride together with PEG 400 in the complexing solution.
Conclusion: To achieve immediate release of paracetamol from alginate beads in the acidic pH, excipients need to be added. Rational selection of
excipients is critical to achieve the desired drug release. |
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