Pharmacokinetic/pharmacodynamics-optimized antimicrobial therapy in patients with hospital-acquired pneumonia/ventilator-associated pneumonia
Hospital-acquired pneumonia and ventilator-associated pneumonia continue to cause significant morbidity and mortality. With increasing rates of antimicrobial resistance, the importance of optimizing antibiotic treatment is key to maximize treatment outcomes. This is especially important in criticall...
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2017
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iium-572352017-07-18T06:09:54Z http://irep.iium.edu.my/57235/ Pharmacokinetic/pharmacodynamics-optimized antimicrobial therapy in patients with hospital-acquired pneumonia/ventilator-associated pneumonia Sulaiman, Helmi Abdul Aziz, Mohd. Hafiz Roberts, Jason A. RC Internal medicine RM Therapeutics. Pharmacology RS Pharmacy and materia medica Hospital-acquired pneumonia and ventilator-associated pneumonia continue to cause significant morbidity and mortality. With increasing rates of antimicrobial resistance, the importance of optimizing antibiotic treatment is key to maximize treatment outcomes. This is especially important in critically ill patients in intensive care units, in whom the infection is usually caused by less susceptible organisms. In addition, the marked physiological changes that can occur in these patients can cause serious changes in antibiotic pharmacokinetics which in turn alter the attainment of therapeutic drug exposures. This article reviews the various aspects of the pharmacokinetic changes that can occur in the critically ill patients, the barriers to achieving therapeutic drug exposures in pneumonia for systemically delivered antibiotics, the optimization for commonly used antibiotics in hospital- and ventilator-associated pneumonia, the agents that should be avoided in the treatment regimen, as well as the use of adjunctive therapy in the form of nebulized antibiotics. 2017-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/57235/1/SRCCM_01275.pdf application/pdf en http://irep.iium.edu.my/57235/7/57235_Pharmacokinetic-Pharmacodynamics-Optimized_Scopus.pdf Sulaiman, Helmi and Abdul Aziz, Mohd. Hafiz and Roberts, Jason A. (2017) Pharmacokinetic/pharmacodynamics-optimized antimicrobial therapy in patients with hospital-acquired pneumonia/ventilator-associated pneumonia. Seminars in Respiratory and Critical Care Medicine, 38 (3). pp. 271-286. ISSN 1069-3424 10.1055/s-0037-1602716 |
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Digital Repository |
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Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
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Online Access |
| language |
English English |
| topic |
RC Internal medicine RM Therapeutics. Pharmacology RS Pharmacy and materia medica |
| spellingShingle |
RC Internal medicine RM Therapeutics. Pharmacology RS Pharmacy and materia medica Sulaiman, Helmi Abdul Aziz, Mohd. Hafiz Roberts, Jason A. Pharmacokinetic/pharmacodynamics-optimized antimicrobial therapy in patients with hospital-acquired pneumonia/ventilator-associated pneumonia |
| description |
Hospital-acquired pneumonia and ventilator-associated pneumonia continue to cause significant morbidity and mortality. With increasing rates of antimicrobial resistance, the importance of optimizing antibiotic treatment is key to maximize treatment outcomes. This is especially important in critically ill patients in intensive care units, in whom the infection is usually caused by less susceptible organisms. In addition, the marked physiological changes that can occur in these patients can cause serious changes in antibiotic pharmacokinetics which in turn alter the attainment of therapeutic drug exposures. This article reviews the various aspects of the pharmacokinetic changes that can occur in the critically ill patients, the barriers to achieving therapeutic drug exposures in pneumonia for systemically delivered antibiotics, the optimization for commonly used antibiotics in hospital- and ventilator-associated pneumonia, the agents that should be avoided in the treatment regimen, as well as the use of adjunctive therapy in the form of nebulized antibiotics. |
| format |
Article |
| author |
Sulaiman, Helmi Abdul Aziz, Mohd. Hafiz Roberts, Jason A. |
| author_facet |
Sulaiman, Helmi Abdul Aziz, Mohd. Hafiz Roberts, Jason A. |
| author_sort |
Sulaiman, Helmi |
| title |
Pharmacokinetic/pharmacodynamics-optimized antimicrobial therapy in patients with hospital-acquired pneumonia/ventilator-associated pneumonia |
| title_short |
Pharmacokinetic/pharmacodynamics-optimized antimicrobial therapy in patients with hospital-acquired pneumonia/ventilator-associated pneumonia |
| title_full |
Pharmacokinetic/pharmacodynamics-optimized antimicrobial therapy in patients with hospital-acquired pneumonia/ventilator-associated pneumonia |
| title_fullStr |
Pharmacokinetic/pharmacodynamics-optimized antimicrobial therapy in patients with hospital-acquired pneumonia/ventilator-associated pneumonia |
| title_full_unstemmed |
Pharmacokinetic/pharmacodynamics-optimized antimicrobial therapy in patients with hospital-acquired pneumonia/ventilator-associated pneumonia |
| title_sort |
pharmacokinetic/pharmacodynamics-optimized antimicrobial therapy in patients with hospital-acquired pneumonia/ventilator-associated pneumonia |
| publishDate |
2017 |
| url |
http://irep.iium.edu.my/57235/ http://irep.iium.edu.my/57235/ http://irep.iium.edu.my/57235/1/SRCCM_01275.pdf http://irep.iium.edu.my/57235/7/57235_Pharmacokinetic-Pharmacodynamics-Optimized_Scopus.pdf |
| first_indexed |
2023-09-18T21:20:52Z |
| last_indexed |
2023-09-18T21:20:52Z |
| _version_ |
1777411872574668800 |