Effect of ethanolic extract of Pericampylus Dawley rats with high fats diets
Objective: To evaluate the effect of ethanolic extract of Pericampylus glaucus (Lam) Merr (P. glaucus) on biochemical parameters in high fats diets treated rats. Methods: The effect of P. glaucus extract on biochemical parameters was studied in male Sprague Dawley rats. The high-fat diets along w...
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| Format: | Article |
| Language: | English |
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Journal of Coastal Life Medicine Editorial Office
2017
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| Online Access: | http://irep.iium.edu.my/57185/ http://irep.iium.edu.my/57185/ http://irep.iium.edu.my/57185/1/Article.pdf |
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iium-571852017-06-06T07:18:13Z http://irep.iium.edu.my/57185/ Effect of ethanolic extract of Pericampylus Dawley rats with high fats diets Muhammad, Kifayatullah Mohd Shahim, Mustapha Jesuraj, Aravinth Vijay Sengupta, Pinaki Muhammad Shahid, Khan ., Kaleemullah RS Pharmacy and materia medica Objective: To evaluate the effect of ethanolic extract of Pericampylus glaucus (Lam) Merr (P. glaucus) on biochemical parameters in high fats diets treated rats. Methods: The effect of P. glaucus extract on biochemical parameters was studied in male Sprague Dawley rats. The high-fat diets along with standard normal laboratory rat’s diets were given for a period of 28 days along with ethanolic extract of P. glaucus and standard drug. The standard group was treated with simvastatin at dose of 80 mg/kg and the tested groups were treated with ethanol extract of P. glaucus at 400, 600 and 800 mg/kg daily for 28 days of the experiment. The weight of animals in each group was measured weekly and the effect of extract and standard on serum lipids profile was evaluated at the end of the study. Results: The results showed that the ethanolic extract of P. glaucus at different doses of 400, 600 and 800 mg/kg and standard drug induced a significant reduction in the body weight (P < 0.001), total cholesterol, triglycerides (TG), low density lipoproteins (LDL) and uric acid levels and increase (P < 0.001) in high density lipoproteins (HDL) as compared to untreated hyperlipidemic group. Conclusions: The present work indicates that the ethanolic extract significantly suppressed the biochemical parameters in high fats diet treated animals, suggesting the antihyperlipidemic potential of P. glaucus. Journal of Coastal Life Medicine Editorial Office 2017-05-22 Article PeerReviewed application/pdf en http://irep.iium.edu.my/57185/1/Article.pdf Muhammad, Kifayatullah and Mohd Shahim, Mustapha and Jesuraj, Aravinth Vijay and Sengupta, Pinaki and Muhammad Shahid, Khan and ., Kaleemullah (2017) Effect of ethanolic extract of Pericampylus Dawley rats with high fats diets. Journal of Coastal Life Medicine, 5 (5). pp. 219-223. E-ISSN 2309-6152 http://oaji.net/articles/2017/2154-1495850719.pdf |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English |
| topic |
RS Pharmacy and materia medica |
| spellingShingle |
RS Pharmacy and materia medica Muhammad, Kifayatullah Mohd Shahim, Mustapha Jesuraj, Aravinth Vijay Sengupta, Pinaki Muhammad Shahid, Khan ., Kaleemullah Effect of ethanolic extract of Pericampylus Dawley rats with high fats diets |
| description |
Objective: To evaluate the effect of ethanolic extract of Pericampylus glaucus (Lam) Merr (P.
glaucus) on biochemical parameters in high fats diets treated rats.
Methods: The effect of P. glaucus extract on biochemical parameters was studied in male
Sprague Dawley rats. The high-fat diets along with standard normal laboratory rat’s diets were
given for a period of 28 days along with ethanolic extract of P. glaucus and standard drug.
The standard group was treated with simvastatin at dose of 80 mg/kg and the tested groups
were treated with ethanol extract of P. glaucus at 400, 600 and 800 mg/kg daily for 28 days of
the experiment. The weight of animals in each group was measured weekly and the effect of
extract and standard on serum lipids profile was evaluated at the end of the study.
Results: The results showed that the ethanolic extract of P. glaucus at different doses of 400,
600 and 800 mg/kg and standard drug induced a significant reduction in the body weight (P
< 0.001), total cholesterol, triglycerides (TG), low density lipoproteins (LDL) and uric acid
levels and increase (P < 0.001) in high density lipoproteins (HDL) as compared to untreated
hyperlipidemic group.
Conclusions: The present work indicates that the ethanolic extract significantly suppressed the
biochemical parameters in high fats diet treated animals, suggesting the antihyperlipidemic
potential of P. glaucus. |
| format |
Article |
| author |
Muhammad, Kifayatullah Mohd Shahim, Mustapha Jesuraj, Aravinth Vijay Sengupta, Pinaki Muhammad Shahid, Khan ., Kaleemullah |
| author_facet |
Muhammad, Kifayatullah Mohd Shahim, Mustapha Jesuraj, Aravinth Vijay Sengupta, Pinaki Muhammad Shahid, Khan ., Kaleemullah |
| author_sort |
Muhammad, Kifayatullah |
| title |
Effect of ethanolic extract of Pericampylus Dawley rats with high fats diets |
| title_short |
Effect of ethanolic extract of Pericampylus Dawley rats with high fats diets |
| title_full |
Effect of ethanolic extract of Pericampylus Dawley rats with high fats diets |
| title_fullStr |
Effect of ethanolic extract of Pericampylus Dawley rats with high fats diets |
| title_full_unstemmed |
Effect of ethanolic extract of Pericampylus Dawley rats with high fats diets |
| title_sort |
effect of ethanolic extract of pericampylus dawley rats with high fats diets |
| publisher |
Journal of Coastal Life Medicine Editorial Office |
| publishDate |
2017 |
| url |
http://irep.iium.edu.my/57185/ http://irep.iium.edu.my/57185/ http://irep.iium.edu.my/57185/1/Article.pdf |
| first_indexed |
2023-09-18T21:20:47Z |
| last_indexed |
2023-09-18T21:20:47Z |
| _version_ |
1777411867523678208 |