Effect of flaxseed extract on the liver histological structure in streptozotocin induced diabetic rats

Introduction: Diabetes mellitus has become a serious warning to mankind health all over the world. The management goal of diabetes is to keep blood glucose levels as close as possible to healthy individuals. Medications used to treat diabetes are usually associated with complications and may cause d...

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Main Authors:	Al-Ani, Imad Matloub Dally, Abired, Ahmed N., Mustafa Al-Ahmad, Basma Ezzat, Abdel Wahab, Emad Mohamad Nafie, Azzubaidi, Marwan Saad
Format:	Article
Language:	English English
Published:	Kulliyyah of Medicine, International Islamic University Malaysia. 2017
Subjects:	QM Human anatomy QP Physiology RB Pathology
Online Access:	http://irep.iium.edu.my/57182/ http://irep.iium.edu.my/57182/ http://irep.iium.edu.my/57182/1/Effect%20of%20Flaxseed%20Extract%20on%20the%20Liver.pdf http://irep.iium.edu.my/57182/7/57182_Effect%20of%20flaxseed%20extract%20on%20the%20liver_Scopus.pdf

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recordtype	eprints
spelling	iium-571822018-04-19T08:31:09Z http://irep.iium.edu.my/57182/ Effect of flaxseed extract on the liver histological structure in streptozotocin induced diabetic rats Al-Ani, Imad Matloub Dally Abired, Ahmed N. Mustafa Al-Ahmad, Basma Ezzat Abdel Wahab, Emad Mohamad Nafie Azzubaidi, Marwan Saad QM Human anatomy QP Physiology RB Pathology Introduction: Diabetes mellitus has become a serious warning to mankind health all over the world. The management goal of diabetes is to keep blood glucose levels as close as possible to healthy individuals. Medications used to treat diabetes are usually associated with complications and may cause different side effects. Many traditional anti-diabetic plants have become popular in the management of diabetes mellitus. Flaxseed has been used as traditional medicine for centuries. Objective: This study aimed to evaluate the hepatoprotective effects of flaxseed extract in streptozotocin (STZ)-induced diabetic rats. Methods: Diabetes mellitus was induced in Sprague-Dawley rats using a single injection of streptozotocin (60 mg/kg i.p.). The rats were divided into five groups of 8 rats each. Group NC, normal control rats; Group NF, normal rats treated with flaxseed extract (400 mg/kg); Group DC, diabetic control rats; Group DG, diabetic rats treated with glibenclamide (0.6 mg/kg); Group DF, diabetic rats treated with flaxseed extract (400 mg/kg); for 4 weeks. Results: There were significant increase in relative liver weight, blood glucose levels in DC group comparing to NC group (p<0.05). The disturbance of these parameters was ameliorated in DF and DG groups. Histological observation revealed congestion of central veins, degeneration of hepatocytes, and reduced glycogen granules in DC group. These pathological changes were ameliorated in the flaxseed extract and glibenclamide treated rats. Conclusion: Flaxseed extract may represent a candidate alternative treatment to control diabetes mellitus and its related hepatopathy. Kulliyyah of Medicine, International Islamic University Malaysia. 2017-06-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/57182/1/Effect%20of%20Flaxseed%20Extract%20on%20the%20Liver.pdf application/pdf en http://irep.iium.edu.my/57182/7/57182_Effect%20of%20flaxseed%20extract%20on%20the%20liver_Scopus.pdf Al-Ani, Imad Matloub Dally and Abired, Ahmed N. and Mustafa Al-Ahmad, Basma Ezzat and Abdel Wahab, Emad Mohamad Nafie and Azzubaidi, Marwan Saad (2017) Effect of flaxseed extract on the liver histological structure in streptozotocin induced diabetic rats. International Medical Journal Malaysia, 16 (1). pp. 91-98. ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/Volume%2016%20No%201/IMJM-Vol-16-p091-098.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QM Human anatomy QP Physiology RB Pathology
spellingShingle	QM Human anatomy QP Physiology RB Pathology Al-Ani, Imad Matloub Dally Abired, Ahmed N. Mustafa Al-Ahmad, Basma Ezzat Abdel Wahab, Emad Mohamad Nafie Azzubaidi, Marwan Saad Effect of flaxseed extract on the liver histological structure in streptozotocin induced diabetic rats
description	Introduction: Diabetes mellitus has become a serious warning to mankind health all over the world. The management goal of diabetes is to keep blood glucose levels as close as possible to healthy individuals. Medications used to treat diabetes are usually associated with complications and may cause different side effects. Many traditional anti-diabetic plants have become popular in the management of diabetes mellitus. Flaxseed has been used as traditional medicine for centuries. Objective: This study aimed to evaluate the hepatoprotective effects of flaxseed extract in streptozotocin (STZ)-induced diabetic rats. Methods: Diabetes mellitus was induced in Sprague-Dawley rats using a single injection of streptozotocin (60 mg/kg i.p.). The rats were divided into five groups of 8 rats each. Group NC, normal control rats; Group NF, normal rats treated with flaxseed extract (400 mg/kg); Group DC, diabetic control rats; Group DG, diabetic rats treated with glibenclamide (0.6 mg/kg); Group DF, diabetic rats treated with flaxseed extract (400 mg/kg); for 4 weeks. Results: There were significant increase in relative liver weight, blood glucose levels in DC group comparing to NC group (p<0.05). The disturbance of these parameters was ameliorated in DF and DG groups. Histological observation revealed congestion of central veins, degeneration of hepatocytes, and reduced glycogen granules in DC group. These pathological changes were ameliorated in the flaxseed extract and glibenclamide treated rats. Conclusion: Flaxseed extract may represent a candidate alternative treatment to control diabetes mellitus and its related hepatopathy.
format	Article
author	Al-Ani, Imad Matloub Dally Abired, Ahmed N. Mustafa Al-Ahmad, Basma Ezzat Abdel Wahab, Emad Mohamad Nafie Azzubaidi, Marwan Saad
author_facet	Al-Ani, Imad Matloub Dally Abired, Ahmed N. Mustafa Al-Ahmad, Basma Ezzat Abdel Wahab, Emad Mohamad Nafie Azzubaidi, Marwan Saad
author_sort	Al-Ani, Imad Matloub Dally
title	Effect of flaxseed extract on the liver histological structure in streptozotocin induced diabetic rats
title_short	Effect of flaxseed extract on the liver histological structure in streptozotocin induced diabetic rats
title_full	Effect of flaxseed extract on the liver histological structure in streptozotocin induced diabetic rats
title_fullStr	Effect of flaxseed extract on the liver histological structure in streptozotocin induced diabetic rats
title_full_unstemmed	Effect of flaxseed extract on the liver histological structure in streptozotocin induced diabetic rats
title_sort	effect of flaxseed extract on the liver histological structure in streptozotocin induced diabetic rats
publisher	Kulliyyah of Medicine, International Islamic University Malaysia.
publishDate	2017
url	http://irep.iium.edu.my/57182/ http://irep.iium.edu.my/57182/ http://irep.iium.edu.my/57182/1/Effect%20of%20Flaxseed%20Extract%20on%20the%20Liver.pdf http://irep.iium.edu.my/57182/7/57182_Effect%20of%20flaxseed%20extract%20on%20the%20liver_Scopus.pdf
first_indexed	2023-09-18T21:20:47Z
last_indexed	2023-09-18T21:20:47Z
_version_	1777411867227979776

Effect of flaxseed extract on the liver histological structure in streptozotocin induced diabetic rats

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