Anti-atherosclerotic effects of Eurycoma Longifolia (Tongkat Ali) in rats fed on high-fat diet

Atherosclerosis in cardiovascular disease (CVD) is a growing health problem, especially in developing countries. Hyperlipidemia is known as a dominant risk factor for the development of atherosclerosis. This study was designed to investigate the effects of Eurycoma Longifolia (EL) also known as Mala...

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Main Authors:	Al-Joufi, Fakhria, Saxena, Anil Kumar, Al-Ani, Imad Matloub Dally, Talib, Norlelawati A., Mokhtar, Rafidah Hanim, Ku-Zaifah, Norsidah
Format:	Article
Language:	English English
Published:	International Islamic University Malaysia. 2017
Subjects:	QM Human anatomy QP Physiology RB Pathology RM Therapeutics. Pharmacology RM214 Diet therapy. Diet and dietectics in disease
Online Access:	http://irep.iium.edu.my/57180/ http://irep.iium.edu.my/57180/ http://irep.iium.edu.my/57180/1/Anti-atherosclerotic%20Effects%20of%20Eurycoma.pdf http://irep.iium.edu.my/57180/7/57180_Anti-atherosclerotic%20effects%20of%20Eurycoma%20Longifolia%20%28Tongkat%20Ali%29%20in%20rats%20fed%20on%20high-fat%20diet_SCOPUS.pdf

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spelling	iium-571802018-04-02T09:04:08Z http://irep.iium.edu.my/57180/ Anti-atherosclerotic effects of Eurycoma Longifolia (Tongkat Ali) in rats fed on high-fat diet Al-Joufi, Fakhria Saxena, Anil Kumar Al-Ani, Imad Matloub Dally Talib, Norlelawati A. Mokhtar, Rafidah Hanim Ku-Zaifah, Norsidah QM Human anatomy QP Physiology RB Pathology RM Therapeutics. Pharmacology RM214 Diet therapy. Diet and dietectics in disease Atherosclerosis in cardiovascular disease (CVD) is a growing health problem, especially in developing countries. Hyperlipidemia is known as a dominant risk factor for the development of atherosclerosis. This study was designed to investigate the effects of Eurycoma Longifolia (EL) also known as Malaysian Ginseng/Tongkat Ali on the testosterone level, biochemical changes of lipid profile and intima media thickness (IMT) in rats fed on high-fat diet. Twenty young, adult male Sprague-Dawley (SD) rats were housed for 12 weeks. After one week of acclimatization, they were randomly divided into four groups of 5 animals each and treated for 12 weeks as follow: Group ND was given only normal diet, group NDEL was given normal diet and EL extracts (15mg/kg) dissolved in distilled water, group HFD was given only high fat diet and group HFDEL was given high fat diet and EL extracts (15mg/kg). Rats which were treated with EL (NDEL and HFDEL) showed a significant increase (p<0.05) in the testosterone levels. There was a significant decrease (p<0.05) in triglyceride (TG) in HFDEL group compered to HFD group. The histological sections of aortas revealed a significant decrease (p<0.05) in IMT in HFDEL as compared with HFD group. No histological changes were observed in NDEL group compared with ND group and there was no significant difference in IMT values between NDEL and ND. These findings suggest that EL is a promising protective agent against atherosclerosis induced by high-fat diet. International Islamic University Malaysia. 2017-06-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/57180/1/Anti-atherosclerotic%20Effects%20of%20Eurycoma.pdf application/pdf en http://irep.iium.edu.my/57180/7/57180_Anti-atherosclerotic%20effects%20of%20Eurycoma%20Longifolia%20%28Tongkat%20Ali%29%20in%20rats%20fed%20on%20high-fat%20diet_SCOPUS.pdf Al-Joufi, Fakhria and Saxena, Anil Kumar and Al-Ani, Imad Matloub Dally and Talib, Norlelawati A. and Mokhtar, Rafidah Hanim and Ku-Zaifah, Norsidah (2017) Anti-atherosclerotic effects of Eurycoma Longifolia (Tongkat Ali) in rats fed on high-fat diet. The International Medical Journal Malaysia, 16 (1). pp. 83-90. ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/Volume%2016%20No%201/IMJM-Vol-16-p083-090.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QM Human anatomy QP Physiology RB Pathology RM Therapeutics. Pharmacology RM214 Diet therapy. Diet and dietectics in disease
spellingShingle	QM Human anatomy QP Physiology RB Pathology RM Therapeutics. Pharmacology RM214 Diet therapy. Diet and dietectics in disease Al-Joufi, Fakhria Saxena, Anil Kumar Al-Ani, Imad Matloub Dally Talib, Norlelawati A. Mokhtar, Rafidah Hanim Ku-Zaifah, Norsidah Anti-atherosclerotic effects of Eurycoma Longifolia (Tongkat Ali) in rats fed on high-fat diet
description	Atherosclerosis in cardiovascular disease (CVD) is a growing health problem, especially in developing countries. Hyperlipidemia is known as a dominant risk factor for the development of atherosclerosis. This study was designed to investigate the effects of Eurycoma Longifolia (EL) also known as Malaysian Ginseng/Tongkat Ali on the testosterone level, biochemical changes of lipid profile and intima media thickness (IMT) in rats fed on high-fat diet. Twenty young, adult male Sprague-Dawley (SD) rats were housed for 12 weeks. After one week of acclimatization, they were randomly divided into four groups of 5 animals each and treated for 12 weeks as follow: Group ND was given only normal diet, group NDEL was given normal diet and EL extracts (15mg/kg) dissolved in distilled water, group HFD was given only high fat diet and group HFDEL was given high fat diet and EL extracts (15mg/kg). Rats which were treated with EL (NDEL and HFDEL) showed a significant increase (p<0.05) in the testosterone levels. There was a significant decrease (p<0.05) in triglyceride (TG) in HFDEL group compered to HFD group. The histological sections of aortas revealed a significant decrease (p<0.05) in IMT in HFDEL as compared with HFD group. No histological changes were observed in NDEL group compared with ND group and there was no significant difference in IMT values between NDEL and ND. These findings suggest that EL is a promising protective agent against atherosclerosis induced by high-fat diet.
format	Article
author	Al-Joufi, Fakhria Saxena, Anil Kumar Al-Ani, Imad Matloub Dally Talib, Norlelawati A. Mokhtar, Rafidah Hanim Ku-Zaifah, Norsidah
author_facet	Al-Joufi, Fakhria Saxena, Anil Kumar Al-Ani, Imad Matloub Dally Talib, Norlelawati A. Mokhtar, Rafidah Hanim Ku-Zaifah, Norsidah
author_sort	Al-Joufi, Fakhria
title	Anti-atherosclerotic effects of Eurycoma Longifolia (Tongkat Ali) in rats fed on high-fat diet
title_short	Anti-atherosclerotic effects of Eurycoma Longifolia (Tongkat Ali) in rats fed on high-fat diet
title_full	Anti-atherosclerotic effects of Eurycoma Longifolia (Tongkat Ali) in rats fed on high-fat diet
title_fullStr	Anti-atherosclerotic effects of Eurycoma Longifolia (Tongkat Ali) in rats fed on high-fat diet
title_full_unstemmed	Anti-atherosclerotic effects of Eurycoma Longifolia (Tongkat Ali) in rats fed on high-fat diet
title_sort	anti-atherosclerotic effects of eurycoma longifolia (tongkat ali) in rats fed on high-fat diet
publisher	International Islamic University Malaysia.
publishDate	2017
url	http://irep.iium.edu.my/57180/ http://irep.iium.edu.my/57180/ http://irep.iium.edu.my/57180/1/Anti-atherosclerotic%20Effects%20of%20Eurycoma.pdf http://irep.iium.edu.my/57180/7/57180_Anti-atherosclerotic%20effects%20of%20Eurycoma%20Longifolia%20%28Tongkat%20Ali%29%20in%20rats%20fed%20on%20high-fat%20diet_SCOPUS.pdf
first_indexed	2023-09-18T21:20:47Z
last_indexed	2023-09-18T21:20:47Z
_version_	1777411867081179136

Anti-atherosclerotic effects of Eurycoma Longifolia (Tongkat Ali) in rats fed on high-fat diet

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