Validating a lower urine output criteria in predicting death in critically ill patients

Introduction: Urine output provides a rapid estimate for kidney function, and its use has been incorporated in the diagnosis of acute kidney injury. However, not many studies had validated its use compared to the plasma creatinine. It has been showed that the ideal urine output threshold for predict...

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Main Authors:	Md Ralib, Azrina, Mat Nor, Mohd Basri
Format:	Article
Language:	English English English
Published:	Kulliyyah of Medicine,, International Medical Journal Malaysia 2017
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/57148/ http://irep.iium.edu.my/57148/ http://irep.iium.edu.my/57148/1/IMJM%20Vol%2016%20p045-052.pdf http://irep.iium.edu.my/57148/7/57148_Validating%20a%20lower%20urine%20output_Scopus.pdf http://irep.iium.edu.my/57148/13/57148_Validating%20a%20lower%20urine%20output_WOS.pdf

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spelling	iium-571482017-10-10T07:32:44Z http://irep.iium.edu.my/57148/ Validating a lower urine output criteria in predicting death in critically ill patients Md Ralib, Azrina Mat Nor, Mohd Basri R Medicine (General) Introduction: Urine output provides a rapid estimate for kidney function, and its use has been incorporated in the diagnosis of acute kidney injury. However, not many studies had validated its use compared to the plasma creatinine. It has been showed that the ideal urine output threshold for prediction of death or the need for dialysis was 0.3 ml/kg/h. We aim to assess this threshold in our local ICU population. Materials and Methods: This was a secondary analysis of an observational study done in critically ill patients. Hourly urine output data was collected, and a moving average of 6-hourly urine output was calculated over the first 48 hours of ICU admission. AKIuo was defined if urine output ≤ 0.5 ml/kg/h, and UO0.3 was defined as urine output ≤ 0.3 ml/kg/h. Results: 143 patients were recruited into the study, of these, 87 (61%) had AKIuo, and 52 (36%) had UO0.3. The AUC of AKIuo in predicting death was 0.62 (0.51 to 0.72), and UO0.3 was 0.66 (0.55 to 0.77). There was lower survival in patients with AKIuo and UO0.3 compared to those without (p=0.01, and 0.001, respectively). However, only UO0.3 but not AKIuo independently predicted death (HR 2.44 (1.15 to 5.18)). Conclusions: A threshold of 6 hourly urine output of 0.3 ml/kg/h but not 0.5 ml/kg/h independently predictive of death. This support previous finding of a lower threshold of urine output criteria for optimal prediction. Kulliyyah of Medicine,, International Medical Journal Malaysia 2017-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/57148/1/IMJM%20Vol%2016%20p045-052.pdf application/pdf en http://irep.iium.edu.my/57148/7/57148_Validating%20a%20lower%20urine%20output_Scopus.pdf application/pdf en http://irep.iium.edu.my/57148/13/57148_Validating%20a%20lower%20urine%20output_WOS.pdf Md Ralib, Azrina and Mat Nor, Mohd Basri (2017) Validating a lower urine output criteria in predicting death in critically ill patients. The International Medical Journal of Malaysia, 16 (1). pp. 45-52. ISSN 1823-4631 http://iiumedic.net/imjm/v1/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Md Ralib, Azrina Mat Nor, Mohd Basri Validating a lower urine output criteria in predicting death in critically ill patients
description	Introduction: Urine output provides a rapid estimate for kidney function, and its use has been incorporated in the diagnosis of acute kidney injury. However, not many studies had validated its use compared to the plasma creatinine. It has been showed that the ideal urine output threshold for prediction of death or the need for dialysis was 0.3 ml/kg/h. We aim to assess this threshold in our local ICU population. Materials and Methods: This was a secondary analysis of an observational study done in critically ill patients. Hourly urine output data was collected, and a moving average of 6-hourly urine output was calculated over the first 48 hours of ICU admission. AKIuo was defined if urine output ≤ 0.5 ml/kg/h, and UO0.3 was defined as urine output ≤ 0.3 ml/kg/h. Results: 143 patients were recruited into the study, of these, 87 (61%) had AKIuo, and 52 (36%) had UO0.3. The AUC of AKIuo in predicting death was 0.62 (0.51 to 0.72), and UO0.3 was 0.66 (0.55 to 0.77). There was lower survival in patients with AKIuo and UO0.3 compared to those without (p=0.01, and 0.001, respectively). However, only UO0.3 but not AKIuo independently predicted death (HR 2.44 (1.15 to 5.18)). Conclusions: A threshold of 6 hourly urine output of 0.3 ml/kg/h but not 0.5 ml/kg/h independently predictive of death. This support previous finding of a lower threshold of urine output criteria for optimal prediction.
format	Article
author	Md Ralib, Azrina Mat Nor, Mohd Basri
author_facet	Md Ralib, Azrina Mat Nor, Mohd Basri
author_sort	Md Ralib, Azrina
title	Validating a lower urine output criteria in predicting death in critically ill patients
title_short	Validating a lower urine output criteria in predicting death in critically ill patients
title_full	Validating a lower urine output criteria in predicting death in critically ill patients
title_fullStr	Validating a lower urine output criteria in predicting death in critically ill patients
title_full_unstemmed	Validating a lower urine output criteria in predicting death in critically ill patients
title_sort	validating a lower urine output criteria in predicting death in critically ill patients
publisher	Kulliyyah of Medicine,, International Medical Journal Malaysia
publishDate	2017
url	http://irep.iium.edu.my/57148/ http://irep.iium.edu.my/57148/ http://irep.iium.edu.my/57148/1/IMJM%20Vol%2016%20p045-052.pdf http://irep.iium.edu.my/57148/7/57148_Validating%20a%20lower%20urine%20output_Scopus.pdf http://irep.iium.edu.my/57148/13/57148_Validating%20a%20lower%20urine%20output_WOS.pdf
first_indexed	2023-09-18T21:20:43Z
last_indexed	2023-09-18T21:20:43Z
_version_	1777411863441571840

Validating a lower urine output criteria in predicting death in critically ill patients

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