Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10

Endophytic Streptomyces strains are potential sources for novel bioactive molecules. In this study, the diketopiperazine gancidin W (GW) was isolated from the endophytic actinobacterial genus Streptomyces, SUK10, obtained from the bark of Shorea ovalis tree, and it was tested in vivo against Plasmod...

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Main Authors:	Mohamad Zin, Noraziah, Baba, Mohd Shukri, Zainal-Abidin, Abu Hassan, Latip, Jalifah, Mazlan, Noor Wini, RuAngelie, Edrada-Ebel
Format:	Article
Language:	English English English
Published:	Dove Medical Press Ltd. 2017
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/57103/ http://irep.iium.edu.my/57103/ http://irep.iium.edu.my/57103/1/57103_Gancidin%20W%2C%20a%20potential%20low-toxicity.pdf http://irep.iium.edu.my/57103/2/57103_Gancidin%20W%2C%20a%20potential%20low-toxicity_SCOPUS.pdf http://irep.iium.edu.my/57103/3/57103_Gancidin%20W%2C%20a%20potential%20low-toxicity_WOS.pdf

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spelling	iium-571032019-10-14T01:43:14Z http://irep.iium.edu.my/57103/ Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10 Mohamad Zin, Noraziah Baba, Mohd Shukri Zainal-Abidin, Abu Hassan Latip, Jalifah Mazlan, Noor Wini RuAngelie, Edrada-Ebel QD Chemistry Endophytic Streptomyces strains are potential sources for novel bioactive molecules. In this study, the diketopiperazine gancidin W (GW) was isolated from the endophytic actinobacterial genus Streptomyces, SUK10, obtained from the bark of Shorea ovalis tree, and it was tested in vivo against Plasmodium berghei PZZ1/100. GW exhibited an inhibition rate of nearly 80% at 6.25 and 3.125 mu g kg(-1) body weight on day four using the 4-day suppression test method on male ICR strain mice. Comparing GW at both concentrations with quinine hydrochloride and normal saline as positive and negative controls, respectively, 50% of the mice treated with 3.125 mu g kg-1 body weight managed to survive for more than 11 months after infection, which almost reached the life span of normal mice. Biochemical tests of selected enzymes and proteins in blood samples of mice treated with GW were also within normal levels; in addition, no abnormalities or injuries were found on internal vital organs. These findings indicated that this isolated bioactive compound from Streptomyces SUK10 exhibits very low toxicity and is a good candidate for potential use as an antimalarial agent in an animal model. Dove Medical Press Ltd. 2017-02 Article PeerReviewed application/pdf en http://irep.iium.edu.my/57103/1/57103_Gancidin%20W%2C%20a%20potential%20low-toxicity.pdf application/pdf en http://irep.iium.edu.my/57103/2/57103_Gancidin%20W%2C%20a%20potential%20low-toxicity_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/57103/3/57103_Gancidin%20W%2C%20a%20potential%20low-toxicity_WOS.pdf Mohamad Zin, Noraziah and Baba, Mohd Shukri and Zainal-Abidin, Abu Hassan and Latip, Jalifah and Mazlan, Noor Wini and RuAngelie, Edrada-Ebel (2017) Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10. Drug Design, Development and Therapy, 11. pp. 351-363. ISSN 1177-8881 https://www.dovepress.com/gancidin-w-a-potential-low-toxicity-antimalarial-agent-isolated-from-a-peer-reviewed-fulltext-article-DDDT
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	QD Chemistry
spellingShingle	QD Chemistry Mohamad Zin, Noraziah Baba, Mohd Shukri Zainal-Abidin, Abu Hassan Latip, Jalifah Mazlan, Noor Wini RuAngelie, Edrada-Ebel Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10
description	Endophytic Streptomyces strains are potential sources for novel bioactive molecules. In this study, the diketopiperazine gancidin W (GW) was isolated from the endophytic actinobacterial genus Streptomyces, SUK10, obtained from the bark of Shorea ovalis tree, and it was tested in vivo against Plasmodium berghei PZZ1/100. GW exhibited an inhibition rate of nearly 80% at 6.25 and 3.125 mu g kg(-1) body weight on day four using the 4-day suppression test method on male ICR strain mice. Comparing GW at both concentrations with quinine hydrochloride and normal saline as positive and negative controls, respectively, 50% of the mice treated with 3.125 mu g kg-1 body weight managed to survive for more than 11 months after infection, which almost reached the life span of normal mice. Biochemical tests of selected enzymes and proteins in blood samples of mice treated with GW were also within normal levels; in addition, no abnormalities or injuries were found on internal vital organs. These findings indicated that this isolated bioactive compound from Streptomyces SUK10 exhibits very low toxicity and is a good candidate for potential use as an antimalarial agent in an animal model.
format	Article
author	Mohamad Zin, Noraziah Baba, Mohd Shukri Zainal-Abidin, Abu Hassan Latip, Jalifah Mazlan, Noor Wini RuAngelie, Edrada-Ebel
author_facet	Mohamad Zin, Noraziah Baba, Mohd Shukri Zainal-Abidin, Abu Hassan Latip, Jalifah Mazlan, Noor Wini RuAngelie, Edrada-Ebel
author_sort	Mohamad Zin, Noraziah
title	Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10
title_short	Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10
title_full	Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10
title_fullStr	Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10
title_full_unstemmed	Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10
title_sort	gancidin w, a potential low-toxicity antimalarial agent isolated from an endophytic streptomyces suk10
publisher	Dove Medical Press Ltd.
publishDate	2017
url	http://irep.iium.edu.my/57103/ http://irep.iium.edu.my/57103/ http://irep.iium.edu.my/57103/1/57103_Gancidin%20W%2C%20a%20potential%20low-toxicity.pdf http://irep.iium.edu.my/57103/2/57103_Gancidin%20W%2C%20a%20potential%20low-toxicity_SCOPUS.pdf http://irep.iium.edu.my/57103/3/57103_Gancidin%20W%2C%20a%20potential%20low-toxicity_WOS.pdf
first_indexed	2023-09-18T21:20:40Z
last_indexed	2023-09-18T21:20:40Z
_version_	1777411859460128768

Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10

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