Tau protein as a biomarker for asphyxia: a possible forensic tool?

Asphyxial death has been a problem for forensic investigations due to the absence of a validated biomarker for the diagnosis of this event. Recently, research on brain affection by asphyxia raised hopes on the possible use of CNSmarkers for asphyxia. The cytoskeletal proteins seemto be attractive...

Full description

Bibliographic Details
Main Authors:	Salama, Mohamed, Mohamed, Wael Mohamed Yousef
Format:	Article
Language:	English English
Published:	Elsevier 2016
Subjects:	RA1001 Forensic Medicine. Medical jurisprudence. Legal medicine RB Pathology
Online Access:	http://irep.iium.edu.my/57059/ http://irep.iium.edu.my/57059/ http://irep.iium.edu.my/57059/ http://irep.iium.edu.my/57059/1/Tau.pdf http://irep.iium.edu.my/57059/8/57059-Tau%20protein%20as%20a%20biomarker_SCOPUS.pdf

id	iium-57059
recordtype	eprints
spelling	iium-570592017-10-09T08:17:43Z http://irep.iium.edu.my/57059/ Tau protein as a biomarker for asphyxia: a possible forensic tool? Salama, Mohamed Mohamed, Wael Mohamed Yousef RA1001 Forensic Medicine. Medical jurisprudence. Legal medicine RB Pathology Asphyxial death has been a problem for forensic investigations due to the absence of a validated biomarker for the diagnosis of this event. Recently, research on brain affection by asphyxia raised hopes on the possible use of CNSmarkers for asphyxia. The cytoskeletal proteins seemto be attractive targets as they are vulnerable to hypoxia and can be affected in asphyxial deaths. Tau, an important cytoskeletal protein, showed affection in many neurodegenerative disorders and recently in some acute incidences like trauma and brain ischemia. In this report we showthe affection of the normal pattern of tau and pathological aggregates of tau in the case of brain hypoxia. This may give new clues to asphyxial death investigations. Elsevier 2016-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/57059/1/Tau.pdf application/pdf en http://irep.iium.edu.my/57059/8/57059-Tau%20protein%20as%20a%20biomarker_SCOPUS.pdf Salama, Mohamed and Mohamed, Wael Mohamed Yousef (2016) Tau protein as a biomarker for asphyxia: a possible forensic tool? Applied and Translational Genomics, 9. pp. 20-22. ISSN 2212-0661 http://www.sciencedirect.com/science/article/pii/S221206611630014X 10.1016/j.atg.2016.03.001
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RA1001 Forensic Medicine. Medical jurisprudence. Legal medicine RB Pathology
spellingShingle	RA1001 Forensic Medicine. Medical jurisprudence. Legal medicine RB Pathology Salama, Mohamed Mohamed, Wael Mohamed Yousef Tau protein as a biomarker for asphyxia: a possible forensic tool?
description	Asphyxial death has been a problem for forensic investigations due to the absence of a validated biomarker for the diagnosis of this event. Recently, research on brain affection by asphyxia raised hopes on the possible use of CNSmarkers for asphyxia. The cytoskeletal proteins seemto be attractive targets as they are vulnerable to hypoxia and can be affected in asphyxial deaths. Tau, an important cytoskeletal protein, showed affection in many neurodegenerative disorders and recently in some acute incidences like trauma and brain ischemia. In this report we showthe affection of the normal pattern of tau and pathological aggregates of tau in the case of brain hypoxia. This may give new clues to asphyxial death investigations.
format	Article
author	Salama, Mohamed Mohamed, Wael Mohamed Yousef
author_facet	Salama, Mohamed Mohamed, Wael Mohamed Yousef
author_sort	Salama, Mohamed
title	Tau protein as a biomarker for asphyxia: a possible forensic tool?
title_short	Tau protein as a biomarker for asphyxia: a possible forensic tool?
title_full	Tau protein as a biomarker for asphyxia: a possible forensic tool?
title_fullStr	Tau protein as a biomarker for asphyxia: a possible forensic tool?
title_full_unstemmed	Tau protein as a biomarker for asphyxia: a possible forensic tool?
title_sort	tau protein as a biomarker for asphyxia: a possible forensic tool?
publisher	Elsevier
publishDate	2016
url	http://irep.iium.edu.my/57059/ http://irep.iium.edu.my/57059/ http://irep.iium.edu.my/57059/ http://irep.iium.edu.my/57059/1/Tau.pdf http://irep.iium.edu.my/57059/8/57059-Tau%20protein%20as%20a%20biomarker_SCOPUS.pdf
first_indexed	2023-09-18T21:20:36Z
last_indexed	2023-09-18T21:20:36Z
_version_	1777411855627583488

Tau protein as a biomarker for asphyxia: a possible forensic tool?

Similar Items