Tau protein as a biomarker for asphyxia: a possible forensic tool?
Asphyxial death has been a problem for forensic investigations due to the absence of a validated biomarker for the diagnosis of this event. Recently, research on brain affection by asphyxia raised hopes on the possible use of CNSmarkers for asphyxia. The cytoskeletal proteins seemto be attractive...
| Main Authors: | , |
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| Format: | Article |
| Language: | English English |
| Published: |
Elsevier
2016
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/57059/ http://irep.iium.edu.my/57059/ http://irep.iium.edu.my/57059/ http://irep.iium.edu.my/57059/1/Tau.pdf http://irep.iium.edu.my/57059/8/57059-Tau%20protein%20as%20a%20biomarker_SCOPUS.pdf |
| Summary: | Asphyxial death has been a problem for forensic investigations due to the absence of a validated biomarker for
the diagnosis of this event. Recently, research on brain affection by asphyxia raised hopes on the possible use
of CNSmarkers for asphyxia. The cytoskeletal proteins seemto be attractive targets as they are vulnerable to hypoxia
and can be affected in asphyxial deaths. Tau, an important cytoskeletal protein, showed affection in many
neurodegenerative disorders and recently in some acute incidences like trauma and brain ischemia. In this report
we showthe affection of the normal pattern of tau and pathological aggregates of tau in the case of brain hypoxia.
This may give new clues to asphyxial death investigations. |
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