Effects of Eurycoma longifolia standardized extract on Estradiol valerate-induced teratogenicity in female rats

Estradiol valerate, a synthetic and steroidal estradiol is used as prescription for the treatment of certain female reproductive disorders as well as contraceptive drugs. Consumption of estradiol valerate during early pregnancy may produce abortional effects especially in cases of unknown pregnancy....

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Main Authors:	Ahmad, Nur Amalina, Abdul Rahman, Suzanah, Chan, Kit-Lam, Abdul Samat, Nadia Hanis, Zahri, Syazana, Abdullah, 'Afif Raihan
Format:	Conference or Workshop Item
Language:	English English
Published:	2017
Subjects:	RG Gynecology and obstetrics RM Therapeutics. Pharmacology RM300 Drugs and their action
Online Access:	http://irep.iium.edu.my/56841/ http://irep.iium.edu.my/56841/24/56841-abstract%20book.pdf http://irep.iium.edu.my/56841/18/AIMC%202017%20Poster_Suzanah.pdf

id	iium-56841
recordtype	eprints
spelling	iium-568412017-05-17T01:19:21Z http://irep.iium.edu.my/56841/ Effects of Eurycoma longifolia standardized extract on Estradiol valerate-induced teratogenicity in female rats Ahmad, Nur Amalina Abdul Rahman, Suzanah Chan, Kit-Lam Abdul Samat, Nadia Hanis Zahri, Syazana Abdullah, 'Afif Raihan RG Gynecology and obstetrics RM Therapeutics. Pharmacology RM300 Drugs and their action Estradiol valerate, a synthetic and steroidal estradiol is used as prescription for the treatment of certain female reproductive disorders as well as contraceptive drugs. Consumption of estradiol valerate during early pregnancy may produce abortional effects especially in cases of unknown pregnancy. Teratogenic effects have also been detected at toxic levels of the agent. This study therefore aims to investigate the possible effects of standardized extract of Eurycoma longifolia, TAF 273, on foetus development in female rats exposed to estradiol valerate. Pregnant female rats on day 12 of gestation (GD12) were administered with a single subcutaneous injection of estradiol valerate (0.15 mg/kg) and were randomly divided into 3 groups of 5 dams each which then received treatment of TAF 273 at doses of 25, 50 and 100 mg/kg body weight orally from day 12 gestation (GD12) until day 19 gestation (GD19). Pregnancy was terminated on day 21 of gestation (GD21) and uterus of each dam was carefully excised and the foetuses were examined for morphological observations. Results showed that exposure to estradiol valerate decreased the number of live foetuses with high number of pre-implantation loss and early resorption. Foetuses in the group treated with 100 mg/kg TAF 273 extract showed high number of live foetuses but with decreased body weight and crown-rump length as the number of embryo in the uterus also affect the availability of space for embryonic development and blood supply which relates to nutrition received by the foetuses. Observations of abnormalities in the form of kyphosis, scoliosis and kinky tail in EV group were more pronounced than in control and treatments group. The present study suggests that Eurycoma longifolia may have potential in ameliorating the teratogenic effects of estradiol valerate by reducing external abnormalities in the rat foetuses. Eurycoma longifolia may have prospective use in the treatment of female-linked disorders and complications. 2017 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/56841/24/56841-abstract%20book.pdf application/pdf en http://irep.iium.edu.my/56841/18/AIMC%202017%20Poster_Suzanah.pdf Ahmad, Nur Amalina and Abdul Rahman, Suzanah and Chan, Kit-Lam and Abdul Samat, Nadia Hanis and Zahri, Syazana and Abdullah, 'Afif Raihan (2017) Effects of Eurycoma longifolia standardized extract on Estradiol valerate-induced teratogenicity in female rats. In: ASIA International Multidisciplinary Conference (AIMC 2017), 1st-2nd May 2017, Johor Bharu, Johor. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RG Gynecology and obstetrics RM Therapeutics. Pharmacology RM300 Drugs and their action
spellingShingle	RG Gynecology and obstetrics RM Therapeutics. Pharmacology RM300 Drugs and their action Ahmad, Nur Amalina Abdul Rahman, Suzanah Chan, Kit-Lam Abdul Samat, Nadia Hanis Zahri, Syazana Abdullah, 'Afif Raihan Effects of Eurycoma longifolia standardized extract on Estradiol valerate-induced teratogenicity in female rats
description	Estradiol valerate, a synthetic and steroidal estradiol is used as prescription for the treatment of certain female reproductive disorders as well as contraceptive drugs. Consumption of estradiol valerate during early pregnancy may produce abortional effects especially in cases of unknown pregnancy. Teratogenic effects have also been detected at toxic levels of the agent. This study therefore aims to investigate the possible effects of standardized extract of Eurycoma longifolia, TAF 273, on foetus development in female rats exposed to estradiol valerate. Pregnant female rats on day 12 of gestation (GD12) were administered with a single subcutaneous injection of estradiol valerate (0.15 mg/kg) and were randomly divided into 3 groups of 5 dams each which then received treatment of TAF 273 at doses of 25, 50 and 100 mg/kg body weight orally from day 12 gestation (GD12) until day 19 gestation (GD19). Pregnancy was terminated on day 21 of gestation (GD21) and uterus of each dam was carefully excised and the foetuses were examined for morphological observations. Results showed that exposure to estradiol valerate decreased the number of live foetuses with high number of pre-implantation loss and early resorption. Foetuses in the group treated with 100 mg/kg TAF 273 extract showed high number of live foetuses but with decreased body weight and crown-rump length as the number of embryo in the uterus also affect the availability of space for embryonic development and blood supply which relates to nutrition received by the foetuses. Observations of abnormalities in the form of kyphosis, scoliosis and kinky tail in EV group were more pronounced than in control and treatments group. The present study suggests that Eurycoma longifolia may have potential in ameliorating the teratogenic effects of estradiol valerate by reducing external abnormalities in the rat foetuses. Eurycoma longifolia may have prospective use in the treatment of female-linked disorders and complications.
format	Conference or Workshop Item
author	Ahmad, Nur Amalina Abdul Rahman, Suzanah Chan, Kit-Lam Abdul Samat, Nadia Hanis Zahri, Syazana Abdullah, 'Afif Raihan
author_facet	Ahmad, Nur Amalina Abdul Rahman, Suzanah Chan, Kit-Lam Abdul Samat, Nadia Hanis Zahri, Syazana Abdullah, 'Afif Raihan
author_sort	Ahmad, Nur Amalina
title	Effects of Eurycoma longifolia standardized extract on Estradiol valerate-induced teratogenicity in female rats
title_short	Effects of Eurycoma longifolia standardized extract on Estradiol valerate-induced teratogenicity in female rats
title_full	Effects of Eurycoma longifolia standardized extract on Estradiol valerate-induced teratogenicity in female rats
title_fullStr	Effects of Eurycoma longifolia standardized extract on Estradiol valerate-induced teratogenicity in female rats
title_full_unstemmed	Effects of Eurycoma longifolia standardized extract on Estradiol valerate-induced teratogenicity in female rats
title_sort	effects of eurycoma longifolia standardized extract on estradiol valerate-induced teratogenicity in female rats
publishDate	2017
url	http://irep.iium.edu.my/56841/ http://irep.iium.edu.my/56841/24/56841-abstract%20book.pdf http://irep.iium.edu.my/56841/18/AIMC%202017%20Poster_Suzanah.pdf
first_indexed	2023-09-18T21:20:15Z
last_indexed	2023-09-18T21:20:15Z
_version_	1777411833407209472

Effects of Eurycoma longifolia standardized extract on Estradiol valerate-induced teratogenicity in female rats

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