Potential and future scope of nanoemulgel formulation for topical delivery of lipophilic drugs

The aim of this review is to evaluate and report the current potential and future scope of nanoemulgel formulation for becoming an effective delivery system for poorly water soluble drugs. In this review, we have summarized and discussed the outcome of different studies on permeability, pharmacok...

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Main Authors:	Sengupta, Pinaki, Chatterjee, Bappaditya
Format:	Article
Language:	English English
Published:	Elsevier 2017
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/56754/ http://irep.iium.edu.my/56754/ http://irep.iium.edu.my/56754/ http://irep.iium.edu.my/56754/1/Accepted%20Manuscript%20IJP.pdf http://irep.iium.edu.my/56754/8/Potential%20and%20future%20scope%20of%20nanoemulgel%20formulation%20for%20topical%20delivery%20of%20lipophilic%20drugs.pdf

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spelling	iium-567542018-01-26T05:10:47Z http://irep.iium.edu.my/56754/ Potential and future scope of nanoemulgel formulation for topical delivery of lipophilic drugs Sengupta, Pinaki Chatterjee, Bappaditya RS Pharmacy and materia medica The aim of this review is to evaluate and report the current potential and future scope of nanoemulgel formulation for becoming an effective delivery system for poorly water soluble drugs. In this review, we have summarized and discussed the outcome of different studies on permeability, pharmacokinetic, pharmacodynamic and safety profile of the drugs delivered topically through nanoemulgel. Rationality of use along with the major challenges to overcome for nanoemulgel formulation has been discussed. The Nanoemulgel drug delivery system is a formulation related intervention to improve the systemic delivery and therapeutic profile of lipophilic drugs. Nanoemulgel is an amalgamated formulation of two different systems in which nanoemulsion containing drug is incorporated into a gel base. The fusion of the two systems makes this formulation advantageous in several ways. Lipophilic drugs can be easily incorporated and the skin permeability of the incorporated drugs can be enhanced in several folds due to the finely distributed droplets of nanoemulsion phase. As a result, the pharmacokinetic and pharmacodynamic profiles of the lipophilic drugs are improved significantly. An increasing trend in nanoemulgel use in recent years has been noticed because of the better acceptability of the preparation to the patients due to their, noninvasive drug delivery, avoidance of gastrointestinal side effects, easier applicability and good therapeutic and safety profile. Despite of having few limitations, nanoemulgel formulation can be considered as a potential and promising candidates for topical delivery of lipophilic drugs in the future. Elsevier 2017-04-28 Article PeerReviewed application/pdf en http://irep.iium.edu.my/56754/1/Accepted%20Manuscript%20IJP.pdf application/pdf en http://irep.iium.edu.my/56754/8/Potential%20and%20future%20scope%20of%20nanoemulgel%20formulation%20for%20topical%20delivery%20of%20lipophilic%20drugs.pdf Sengupta, Pinaki and Chatterjee, Bappaditya (2017) Potential and future scope of nanoemulgel formulation for topical delivery of lipophilic drugs. International Journal of Pharmaceutics, 526 (1-2). pp. 353-365. ISSN 0378-5173 http://www.sciencedirect.com/science/article/pii/S0378517317303782 10.1016/j.ijpharm.2017.04.068
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Sengupta, Pinaki Chatterjee, Bappaditya Potential and future scope of nanoemulgel formulation for topical delivery of lipophilic drugs
description	The aim of this review is to evaluate and report the current potential and future scope of nanoemulgel formulation for becoming an effective delivery system for poorly water soluble drugs. In this review, we have summarized and discussed the outcome of different studies on permeability, pharmacokinetic, pharmacodynamic and safety profile of the drugs delivered topically through nanoemulgel. Rationality of use along with the major challenges to overcome for nanoemulgel formulation has been discussed. The Nanoemulgel drug delivery system is a formulation related intervention to improve the systemic delivery and therapeutic profile of lipophilic drugs. Nanoemulgel is an amalgamated formulation of two different systems in which nanoemulsion containing drug is incorporated into a gel base. The fusion of the two systems makes this formulation advantageous in several ways. Lipophilic drugs can be easily incorporated and the skin permeability of the incorporated drugs can be enhanced in several folds due to the finely distributed droplets of nanoemulsion phase. As a result, the pharmacokinetic and pharmacodynamic profiles of the lipophilic drugs are improved significantly. An increasing trend in nanoemulgel use in recent years has been noticed because of the better acceptability of the preparation to the patients due to their, noninvasive drug delivery, avoidance of gastrointestinal side effects, easier applicability and good therapeutic and safety profile. Despite of having few limitations, nanoemulgel formulation can be considered as a potential and promising candidates for topical delivery of lipophilic drugs in the future.
format	Article
author	Sengupta, Pinaki Chatterjee, Bappaditya
author_facet	Sengupta, Pinaki Chatterjee, Bappaditya
author_sort	Sengupta, Pinaki
title	Potential and future scope of nanoemulgel formulation for topical delivery of lipophilic drugs
title_short	Potential and future scope of nanoemulgel formulation for topical delivery of lipophilic drugs
title_full	Potential and future scope of nanoemulgel formulation for topical delivery of lipophilic drugs
title_fullStr	Potential and future scope of nanoemulgel formulation for topical delivery of lipophilic drugs
title_full_unstemmed	Potential and future scope of nanoemulgel formulation for topical delivery of lipophilic drugs
title_sort	potential and future scope of nanoemulgel formulation for topical delivery of lipophilic drugs
publisher	Elsevier
publishDate	2017
url	http://irep.iium.edu.my/56754/ http://irep.iium.edu.my/56754/ http://irep.iium.edu.my/56754/ http://irep.iium.edu.my/56754/1/Accepted%20Manuscript%20IJP.pdf http://irep.iium.edu.my/56754/8/Potential%20and%20future%20scope%20of%20nanoemulgel%20formulation%20for%20topical%20delivery%20of%20lipophilic%20drugs.pdf
first_indexed	2023-09-18T21:20:08Z
last_indexed	2023-09-18T21:20:08Z
_version_	1777411826666962944

Potential and future scope of nanoemulgel formulation for topical delivery of lipophilic drugs

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