Potential and future scope of nanoemulgel formulation for topical delivery of lipophilic drugs
The aim of this review is to evaluate and report the current potential and future scope of nanoemulgel formulation for becoming an effective delivery system for poorly water soluble drugs. In this review, we have summarized and discussed the outcome of different studies on permeability, pharmacok...
| Main Authors: | , |
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| Format: | Article |
| Language: | English English |
| Published: |
Elsevier
2017
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/56754/ http://irep.iium.edu.my/56754/ http://irep.iium.edu.my/56754/ http://irep.iium.edu.my/56754/1/Accepted%20Manuscript%20IJP.pdf http://irep.iium.edu.my/56754/8/Potential%20and%20future%20scope%20of%20nanoemulgel%20formulation%20for%20topical%20delivery%20of%20lipophilic%20drugs.pdf |
| Summary: | The aim of this review is to evaluate and report the current potential and future scope of
nanoemulgel formulation for becoming an effective delivery system for poorly water soluble
drugs. In this review, we have summarized and discussed the outcome of different studies on
permeability, pharmacokinetic, pharmacodynamic and safety profile of the drugs delivered
topically through nanoemulgel. Rationality of use along with the major challenges to
overcome for nanoemulgel formulation has been discussed. The Nanoemulgel drug delivery
system is a formulation related intervention to improve the systemic delivery and therapeutic
profile of lipophilic drugs. Nanoemulgel is an amalgamated formulation of two different
systems in which nanoemulsion containing drug is incorporated into a gel base. The fusion of
the two systems makes this formulation advantageous in several ways. Lipophilic drugs can
be easily incorporated and the skin permeability of the incorporated drugs can be enhanced in
several folds due to the finely distributed droplets of nanoemulsion phase. As a result, the
pharmacokinetic and pharmacodynamic profiles of the lipophilic drugs are improved
significantly. An increasing trend in nanoemulgel use in recent years has been noticed
because of the better acceptability of the preparation to the patients due to their, noninvasive
drug delivery, avoidance of gastrointestinal side effects, easier applicability and good
therapeutic and safety profile. Despite of having few limitations, nanoemulgel formulation
can be considered as a potential and promising candidates for topical delivery of lipophilic
drugs in the future. |
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