Mucoadhesive polymers and their mode of action: a recent update

The potential of mucoadhesive delivery system for sustained delivery of drug has been established few decades back. Different polymeric systems such as single or combined, substituted, conjugated, pre-activated polymer (s) etc. are used to develop such delivery platform. To explain the mucoadhesi...

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Main Authors:	Chatterjee, Bappaditya, Amalina, Nursazreen, Mandal, Uttam Kumar, Sengupta, Pinaki
Format:	Article
Language:	English English English
Published:	Journal of Applied Pharmaceutical Science 2017
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/56690/ http://irep.iium.edu.my/56690/ http://irep.iium.edu.my/56690/2/JAPS%20acceptance.pdf http://irep.iium.edu.my/56690/13/Full%20version%20submitted.pdf http://irep.iium.edu.my/56690/19/56690_Mucoadhesive%20polymers%20and%20their%20mode_Scopus.pdf

id	iium-56690
recordtype	eprints
spelling	iium-566902018-01-08T11:30:13Z http://irep.iium.edu.my/56690/ Mucoadhesive polymers and their mode of action: a recent update Chatterjee, Bappaditya Amalina, Nursazreen Mandal, Uttam Kumar Sengupta, Pinaki RS Pharmacy and materia medica The potential of mucoadhesive delivery system for sustained delivery of drug has been established few decades back. Different polymeric systems such as single or combined, substituted, conjugated, pre-activated polymer (s) etc. are used to develop such delivery platform. To explain the mucoadhesion mechanism, several possible theories namely electronic theory, adsorption theory, wetting theory, diffusion theory, fraction theory and mechanical theory has been proposed. But none of these theories alone can explain the mechanism of mucoadhesion. Various mechanism of mucoadhesion or bioadhesion between polymer and mucin such as H bonding, electrostatic interactions, di-sulfide linkage, van Der Waals attraction etc have been evidenced. Researches are focused to enrich such interaction between the mucous layer and the delivery platform by modifying the system. Wide varieties of polymers such as cationic, anionic, non-ionic, thiolated polymers etc have been used to design and develop mucoadhesive drug delivery system. Therefore reviewing and analyzing the mucoadhesive polymeric system and their mechanism of action is still relevant and necessary. The aim of this current review is to highlight the polymers which are being used under recent scientific researches with emphasis on their mechanism of mucoadhesion. The outcome of this review will help researchers to screen the mucoadhesive polymers for their intended use. Journal of Applied Pharmaceutical Science 2017 Article NonPeerReviewed application/pdf en http://irep.iium.edu.my/56690/2/JAPS%20acceptance.pdf application/pdf en http://irep.iium.edu.my/56690/13/Full%20version%20submitted.pdf application/pdf en http://irep.iium.edu.my/56690/19/56690_Mucoadhesive%20polymers%20and%20their%20mode_Scopus.pdf Chatterjee, Bappaditya and Amalina, Nursazreen and Mandal, Uttam Kumar and Sengupta, Pinaki (2017) Mucoadhesive polymers and their mode of action: a recent update. Journal of Applied Pharmaceutical Science, 7 (5). pp. 195-203. ISSN 2231-3354 (In Press) http://www.japsonline.com/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Chatterjee, Bappaditya Amalina, Nursazreen Mandal, Uttam Kumar Sengupta, Pinaki Mucoadhesive polymers and their mode of action: a recent update
description	The potential of mucoadhesive delivery system for sustained delivery of drug has been established few decades back. Different polymeric systems such as single or combined, substituted, conjugated, pre-activated polymer (s) etc. are used to develop such delivery platform. To explain the mucoadhesion mechanism, several possible theories namely electronic theory, adsorption theory, wetting theory, diffusion theory, fraction theory and mechanical theory has been proposed. But none of these theories alone can explain the mechanism of mucoadhesion. Various mechanism of mucoadhesion or bioadhesion between polymer and mucin such as H bonding, electrostatic interactions, di-sulfide linkage, van Der Waals attraction etc have been evidenced. Researches are focused to enrich such interaction between the mucous layer and the delivery platform by modifying the system. Wide varieties of polymers such as cationic, anionic, non-ionic, thiolated polymers etc have been used to design and develop mucoadhesive drug delivery system. Therefore reviewing and analyzing the mucoadhesive polymeric system and their mechanism of action is still relevant and necessary. The aim of this current review is to highlight the polymers which are being used under recent scientific researches with emphasis on their mechanism of mucoadhesion. The outcome of this review will help researchers to screen the mucoadhesive polymers for their intended use.
format	Article
author	Chatterjee, Bappaditya Amalina, Nursazreen Mandal, Uttam Kumar Sengupta, Pinaki
author_facet	Chatterjee, Bappaditya Amalina, Nursazreen Mandal, Uttam Kumar Sengupta, Pinaki
author_sort	Chatterjee, Bappaditya
title	Mucoadhesive polymers and their mode of action: a recent update
title_short	Mucoadhesive polymers and their mode of action: a recent update
title_full	Mucoadhesive polymers and their mode of action: a recent update
title_fullStr	Mucoadhesive polymers and their mode of action: a recent update
title_full_unstemmed	Mucoadhesive polymers and their mode of action: a recent update
title_sort	mucoadhesive polymers and their mode of action: a recent update
publisher	Journal of Applied Pharmaceutical Science
publishDate	2017
url	http://irep.iium.edu.my/56690/ http://irep.iium.edu.my/56690/ http://irep.iium.edu.my/56690/2/JAPS%20acceptance.pdf http://irep.iium.edu.my/56690/13/Full%20version%20submitted.pdf http://irep.iium.edu.my/56690/19/56690_Mucoadhesive%20polymers%20and%20their%20mode_Scopus.pdf
first_indexed	2023-09-18T21:20:01Z
last_indexed	2023-09-18T21:20:01Z
_version_	1777411819498897408

Mucoadhesive polymers and their mode of action: a recent update

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