Mucoadhesive polymers and their mode of action: a recent update
The potential of mucoadhesive delivery system for sustained delivery of drug has been established few decades back. Different polymeric systems such as single or combined, substituted, conjugated, pre-activated polymer (s) etc. are used to develop such delivery platform. To explain the mucoadhesi...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English English English |
| Published: |
Journal of Applied Pharmaceutical Science
2017
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/56690/ http://irep.iium.edu.my/56690/ http://irep.iium.edu.my/56690/2/JAPS%20acceptance.pdf http://irep.iium.edu.my/56690/13/Full%20version%20submitted.pdf http://irep.iium.edu.my/56690/19/56690_Mucoadhesive%20polymers%20and%20their%20mode_Scopus.pdf |
| Summary: | The potential of mucoadhesive delivery system for sustained delivery of drug has been
established few decades back. Different polymeric systems such as single or combined,
substituted, conjugated, pre-activated polymer (s) etc. are used to develop such delivery
platform. To explain the mucoadhesion mechanism, several possible theories namely
electronic theory, adsorption theory, wetting theory, diffusion theory, fraction theory and
mechanical theory has been proposed. But none of these theories alone can explain the
mechanism of mucoadhesion. Various mechanism of mucoadhesion or bioadhesion between
polymer and mucin such as H bonding, electrostatic interactions, di-sulfide linkage, van Der
Waals attraction etc have been evidenced. Researches are focused to enrich such interaction
between the mucous layer and the delivery platform by modifying the system. Wide varieties
of polymers such as cationic, anionic, non-ionic, thiolated polymers etc have been used to
design and develop mucoadhesive drug delivery system. Therefore reviewing and analyzing
the mucoadhesive polymeric system and their mechanism of action is still relevant and
necessary. The aim of this current review is to highlight the polymers which are being used
under recent scientific researches with emphasis on their mechanism of mucoadhesion. The
outcome of this review will help researchers to screen the mucoadhesive polymers for their
intended use. |
|---|