Effect of neutron irradiation on the physicochemical properties of naproxen sodium

Abstract Pharmaceutical drug delivery systems for non-steroidal anti-inflammatory drugs involve targeted delivery or controlled release of the drug. The most common method to monitor the in vivo behavior of pharmaceutical dosage form is neutron activation based gamma scintigraphy. It is necessary t...

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Main Authors:	D, Sithra, Rahman, Md. Mokhlesur, I, Ibrahim, Awang, Mohamed
Format:	Article
Language:	English
Published:	Trade Science Inc 2016
Subjects:	QD Chemistry RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/56589/ http://irep.iium.edu.my/56589/ http://irep.iium.edu.my/56589/1/Naproxen-sodium_IIUM_CUCMS_2016.pdf

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recordtype	eprints
spelling	iium-565892017-07-03T07:28:47Z http://irep.iium.edu.my/56589/ Effect of neutron irradiation on the physicochemical properties of naproxen sodium D, Sithra Rahman, Md. Mokhlesur I, Ibrahim Awang, Mohamed QD Chemistry RS Pharmacy and materia medica Abstract Pharmaceutical drug delivery systems for non-steroidal anti-inflammatory drugs involve targeted delivery or controlled release of the drug. The most common method to monitor the in vivo behavior of pharmaceutical dosage form is neutron activation based gamma scintigraphy. It is necessary to ensure that the process of neutron irradiation does not affect the physicochemical properties of the formulated drug and its dosage form. This study, the effect of neutron irradiation on the physicochemical properties of naproxen sodium is investigated and it is also; selected as the model drug. The process of neutron irradiation was carried out at the Malaysian Nuclear Agency using the TRIGA MK II reactor. After irradiation times of 1, 2, 3, 4, 5 and 30 min, the effect of neutron irradiation on physicochemical properties of naproxen sodium was investigated using scanning electron microscope (SEM), gas chromatograph-mass spectrometer (GCMS), Fourier transform infrared spectrometer (FTIR) and ifferential scanning calorimeter (DSC). The physicochemical properties of non-irradiated naproxen sodium were compared to the irradiated naproxen sodium samples. Colour changes after irradiation was observed. Results of analysis of SEM and FTIR spectrometer showed changes in the physicochemical properties of naproxen sodium when duration of irradiation was ncreased. There were no major changes in the result of GC-MS and DSC. Based on the results obtained, it can be concluded that naproxen sodium is a suitable drug that can be used for neutron activation based gamma scintigraphy. The maximum irradiation time that naproxen sodium can withstand without changes in its physicochemical properties is 3 min. Trade Science Inc 2016-12-23 Article PeerReviewed application/pdf en http://irep.iium.edu.my/56589/1/Naproxen-sodium_IIUM_CUCMS_2016.pdf D, Sithra and Rahman, Md. Mokhlesur and I, Ibrahim and Awang, Mohamed (2016) Effect of neutron irradiation on the physicochemical properties of naproxen sodium. ChemXpress, 9 (6). pp. 1-15. ISSN 2320-1967 E-ISSN 2320-1975 http://www.tsijournals.com/journals/chemxpress.html
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry RS Pharmacy and materia medica
spellingShingle	QD Chemistry RS Pharmacy and materia medica D, Sithra Rahman, Md. Mokhlesur I, Ibrahim Awang, Mohamed Effect of neutron irradiation on the physicochemical properties of naproxen sodium
description	Abstract Pharmaceutical drug delivery systems for non-steroidal anti-inflammatory drugs involve targeted delivery or controlled release of the drug. The most common method to monitor the in vivo behavior of pharmaceutical dosage form is neutron activation based gamma scintigraphy. It is necessary to ensure that the process of neutron irradiation does not affect the physicochemical properties of the formulated drug and its dosage form. This study, the effect of neutron irradiation on the physicochemical properties of naproxen sodium is investigated and it is also; selected as the model drug. The process of neutron irradiation was carried out at the Malaysian Nuclear Agency using the TRIGA MK II reactor. After irradiation times of 1, 2, 3, 4, 5 and 30 min, the effect of neutron irradiation on physicochemical properties of naproxen sodium was investigated using scanning electron microscope (SEM), gas chromatograph-mass spectrometer (GCMS), Fourier transform infrared spectrometer (FTIR) and ifferential scanning calorimeter (DSC). The physicochemical properties of non-irradiated naproxen sodium were compared to the irradiated naproxen sodium samples. Colour changes after irradiation was observed. Results of analysis of SEM and FTIR spectrometer showed changes in the physicochemical properties of naproxen sodium when duration of irradiation was ncreased. There were no major changes in the result of GC-MS and DSC. Based on the results obtained, it can be concluded that naproxen sodium is a suitable drug that can be used for neutron activation based gamma scintigraphy. The maximum irradiation time that naproxen sodium can withstand without changes in its physicochemical properties is 3 min.
format	Article
author	D, Sithra Rahman, Md. Mokhlesur I, Ibrahim Awang, Mohamed
author_facet	D, Sithra Rahman, Md. Mokhlesur I, Ibrahim Awang, Mohamed
author_sort	D, Sithra
title	Effect of neutron irradiation on the physicochemical properties of naproxen sodium
title_short	Effect of neutron irradiation on the physicochemical properties of naproxen sodium
title_full	Effect of neutron irradiation on the physicochemical properties of naproxen sodium
title_fullStr	Effect of neutron irradiation on the physicochemical properties of naproxen sodium
title_full_unstemmed	Effect of neutron irradiation on the physicochemical properties of naproxen sodium
title_sort	effect of neutron irradiation on the physicochemical properties of naproxen sodium
publisher	Trade Science Inc
publishDate	2016
url	http://irep.iium.edu.my/56589/ http://irep.iium.edu.my/56589/ http://irep.iium.edu.my/56589/1/Naproxen-sodium_IIUM_CUCMS_2016.pdf
first_indexed	2023-09-18T21:19:51Z
last_indexed	2023-09-18T21:19:51Z
_version_	1777411808447954944

Effect of neutron irradiation on the physicochemical properties of naproxen sodium

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