Antimicrobial activity of methyl gallate isolated from the leaves of Glochidion superbum against hospital isolates of methicillin resistant Staphylococcus aureus

An antimicrobial compound has been isolated from the leaves of Glochidion superbum. The compound was determined as methyl 3, 4, 5-trihydroxybenzoate (methyl gallate), based on ultraviolet (UV), infrared (IR), nuclear magnetic resonance (NMR) and mass spectroscopy (MS) analysis. The isolated compound...

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Main Authors:	Ahmed, Mohammed Dahiru, Bakhtiar, Muhammad Taher, Maimusa, Alhaji Hamusu, Rezali, Mohd Fazlin, Mustafa Mahmoud, Mohammed Imad Al-Deen
Format:	Article
Language:	English English
Published:	Korean Society of Pharmacognosy 2017
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/56541/ http://irep.iium.edu.my/56541/ http://irep.iium.edu.my/56541/ http://irep.iium.edu.my/56541/1/Nat%20Prod%20Sci%20Dahiru.pdf http://irep.iium.edu.my/56541/7/56541_Antimicrobial%20activity%20of%20methyl%20gallate_scopus.pdf

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spelling	iium-565412018-03-16T07:47:00Z http://irep.iium.edu.my/56541/ Antimicrobial activity of methyl gallate isolated from the leaves of Glochidion superbum against hospital isolates of methicillin resistant Staphylococcus aureus Ahmed, Mohammed Dahiru Bakhtiar, Muhammad Taher Maimusa, Alhaji Hamusu Rezali, Mohd Fazlin Mustafa Mahmoud, Mohammed Imad Al-Deen RS Pharmacy and materia medica An antimicrobial compound has been isolated from the leaves of Glochidion superbum. The compound was determined as methyl 3, 4, 5-trihydroxybenzoate (methyl gallate), based on ultraviolet (UV), infrared (IR), nuclear magnetic resonance (NMR) and mass spectroscopy (MS) analysis. The isolated compound exhibited potent antimicrobial activity against three clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) by qualitative agar disc diffusion method and quantitative broth dilution method. Agar disc diffusion was done in a dose-dependent manner for each bacterial isolate at disc potencies of 25, 50, 100, and 150 µg/disc. The zones of inhibition were on average equal to 12.27, 14.20, 15.43, and 24.17 mm respectively. The inhibition zones were compared with that of vancomycin disc at 30 µg as a reference standard. The MIC and MBC values were 50 µg/mL and 100 µg/mL respectively. The results of anti MRSA activity were analyzed using one-way ANOVA with Turkey’s HSD and Duncan test. In conclusion, methyl gallate which was isolated from G. superbum showed the inhibition activity against methicillin resistant S. aureus Korean Society of Pharmacognosy 2017 Article PeerReviewed application/pdf en http://irep.iium.edu.my/56541/1/Nat%20Prod%20Sci%20Dahiru.pdf application/pdf en http://irep.iium.edu.my/56541/7/56541_Antimicrobial%20activity%20of%20methyl%20gallate_scopus.pdf Ahmed, Mohammed Dahiru and Bakhtiar, Muhammad Taher and Maimusa, Alhaji Hamusu and Rezali, Mohd Fazlin and Mustafa Mahmoud, Mohammed Imad Al-Deen (2017) Antimicrobial activity of methyl gallate isolated from the leaves of Glochidion superbum against hospital isolates of methicillin resistant Staphylococcus aureus. Natural Product Sciences, 23 (1). pp. 5-8. ISSN 1226-3907 E-ISSN 2288-9027 http://www.e-nps.or.kr/ 10.20307/nps.2017.23.1.5
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Ahmed, Mohammed Dahiru Bakhtiar, Muhammad Taher Maimusa, Alhaji Hamusu Rezali, Mohd Fazlin Mustafa Mahmoud, Mohammed Imad Al-Deen Antimicrobial activity of methyl gallate isolated from the leaves of Glochidion superbum against hospital isolates of methicillin resistant Staphylococcus aureus
description	An antimicrobial compound has been isolated from the leaves of Glochidion superbum. The compound was determined as methyl 3, 4, 5-trihydroxybenzoate (methyl gallate), based on ultraviolet (UV), infrared (IR), nuclear magnetic resonance (NMR) and mass spectroscopy (MS) analysis. The isolated compound exhibited potent antimicrobial activity against three clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) by qualitative agar disc diffusion method and quantitative broth dilution method. Agar disc diffusion was done in a dose-dependent manner for each bacterial isolate at disc potencies of 25, 50, 100, and 150 µg/disc. The zones of inhibition were on average equal to 12.27, 14.20, 15.43, and 24.17 mm respectively. The inhibition zones were compared with that of vancomycin disc at 30 µg as a reference standard. The MIC and MBC values were 50 µg/mL and 100 µg/mL respectively. The results of anti MRSA activity were analyzed using one-way ANOVA with Turkey’s HSD and Duncan test. In conclusion, methyl gallate which was isolated from G. superbum showed the inhibition activity against methicillin resistant S. aureus
format	Article
author	Ahmed, Mohammed Dahiru Bakhtiar, Muhammad Taher Maimusa, Alhaji Hamusu Rezali, Mohd Fazlin Mustafa Mahmoud, Mohammed Imad Al-Deen
author_facet	Ahmed, Mohammed Dahiru Bakhtiar, Muhammad Taher Maimusa, Alhaji Hamusu Rezali, Mohd Fazlin Mustafa Mahmoud, Mohammed Imad Al-Deen
author_sort	Ahmed, Mohammed Dahiru
title	Antimicrobial activity of methyl gallate isolated from the leaves of Glochidion superbum against hospital isolates of methicillin resistant Staphylococcus aureus
title_short	Antimicrobial activity of methyl gallate isolated from the leaves of Glochidion superbum against hospital isolates of methicillin resistant Staphylococcus aureus
title_full	Antimicrobial activity of methyl gallate isolated from the leaves of Glochidion superbum against hospital isolates of methicillin resistant Staphylococcus aureus
title_fullStr	Antimicrobial activity of methyl gallate isolated from the leaves of Glochidion superbum against hospital isolates of methicillin resistant Staphylococcus aureus
title_full_unstemmed	Antimicrobial activity of methyl gallate isolated from the leaves of Glochidion superbum against hospital isolates of methicillin resistant Staphylococcus aureus
title_sort	antimicrobial activity of methyl gallate isolated from the leaves of glochidion superbum against hospital isolates of methicillin resistant staphylococcus aureus
publisher	Korean Society of Pharmacognosy
publishDate	2017
url	http://irep.iium.edu.my/56541/ http://irep.iium.edu.my/56541/ http://irep.iium.edu.my/56541/ http://irep.iium.edu.my/56541/1/Nat%20Prod%20Sci%20Dahiru.pdf http://irep.iium.edu.my/56541/7/56541_Antimicrobial%20activity%20of%20methyl%20gallate_scopus.pdf
first_indexed	2023-09-18T21:19:47Z
last_indexed	2023-09-18T21:19:47Z
_version_	1777411804213805056

Antimicrobial activity of methyl gallate isolated from the leaves of Glochidion superbum against hospital isolates of methicillin resistant Staphylococcus aureus

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