Histological changes in the uterine of female rats after a comparative treatment with Trigonella foenum-graecum seeds and combined oral contraceptive pills

Introduction: This study evaluates the histological changes of uterine tissue in the female Sprague Dawley rats after administration of Trigonella foenum-graecum (fenugreek) seeds in comparison to combined oral contraceptive pills (COCPs). Methods: Twenty four female Sprague Dawley strain rats of...

Full description

Bibliographic Details
Main Authors:	Allow, Ahmed Kaid Naji, Hellis, Ayah Rebhi, Yousef, Zainab, Mohamed Bakrim, Norbaiyah, Ahmed Kaid, Belqees, Saxena, Anil Kumar
Format:	Conference or Workshop Item
Language:	English English
Published:	Kulliyyah of Medicine, International Islamic University Malaysia 2016
Subjects:	RA0421 Public health. Hygiene. Preventive Medicine RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/56477/ http://irep.iium.edu.my/56477/ http://irep.iium.edu.my/56477/1/56477_abstract.pdf http://irep.iium.edu.my/56477/2/56477_Histological%20changes-presentation.pdf

id	iium-56477
recordtype	eprints
spelling	iium-564772018-05-24T01:42:49Z http://irep.iium.edu.my/56477/ Histological changes in the uterine of female rats after a comparative treatment with Trigonella foenum-graecum seeds and combined oral contraceptive pills Allow, Ahmed Kaid Naji Hellis, Ayah Rebhi Yousef, Zainab Mohamed Bakrim, Norbaiyah Ahmed Kaid, Belqees Saxena, Anil Kumar RA0421 Public health. Hygiene. Preventive Medicine RM Therapeutics. Pharmacology Introduction: This study evaluates the histological changes of uterine tissue in the female Sprague Dawley rats after administration of Trigonella foenum-graecum (fenugreek) seeds in comparison to combined oral contraceptive pills (COCPs). Methods: Twenty four female Sprague Dawley strain rats of 8 weeks old were divided into A, B, and C groups. Group A was the control and B was administrated with 0.05 mg/kg body weight of COCPs for 15 days. Group C was treated with 750 mg/kg body weight of fenugreek seed aqueous (FSA) extract for 15 days. The uterine tissues were isolated and studied histologically. Results: The uterine weight in the FSA extract treated group was normal, while in the COCPs treated group it was insignificantly increased. The endometrial thickness and endometrial gland density were normal in the FSA extract treated group, while in the COCPs treated group it was atrophied. Decidual-like cells were observed in the COCPs treated group only. Conclusions: Endometrial atrophy and decidual-like cells were noted after COCPs treatment while in the FSA extract and control groups they were absent. The findings suggest that fenugreek seeds could be used as an alternative natural and safe contraceptive product. Kulliyyah of Medicine, International Islamic University Malaysia 2016 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/56477/1/56477_abstract.pdf application/pdf en http://irep.iium.edu.my/56477/2/56477_Histological%20changes-presentation.pdf Allow, Ahmed Kaid Naji and Hellis, Ayah Rebhi and Yousef, Zainab and Mohamed Bakrim, Norbaiyah and Ahmed Kaid, Belqees and Saxena, Anil Kumar (2016) Histological changes in the uterine of female rats after a comparative treatment with Trigonella foenum-graecum seeds and combined oral contraceptive pills. In: Medical Research Symposium 2015, 10th Dec. 2015, Kuantan, Pahang. http://iiumedic.net/imjm/v1/download/Volume%2015%20Supplement/MRS2016-ABSTRACT-BOOK-65.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RA0421 Public health. Hygiene. Preventive Medicine RM Therapeutics. Pharmacology
spellingShingle	RA0421 Public health. Hygiene. Preventive Medicine RM Therapeutics. Pharmacology Allow, Ahmed Kaid Naji Hellis, Ayah Rebhi Yousef, Zainab Mohamed Bakrim, Norbaiyah Ahmed Kaid, Belqees Saxena, Anil Kumar Histological changes in the uterine of female rats after a comparative treatment with Trigonella foenum-graecum seeds and combined oral contraceptive pills
description	Introduction: This study evaluates the histological changes of uterine tissue in the female Sprague Dawley rats after administration of Trigonella foenum-graecum (fenugreek) seeds in comparison to combined oral contraceptive pills (COCPs). Methods: Twenty four female Sprague Dawley strain rats of 8 weeks old were divided into A, B, and C groups. Group A was the control and B was administrated with 0.05 mg/kg body weight of COCPs for 15 days. Group C was treated with 750 mg/kg body weight of fenugreek seed aqueous (FSA) extract for 15 days. The uterine tissues were isolated and studied histologically. Results: The uterine weight in the FSA extract treated group was normal, while in the COCPs treated group it was insignificantly increased. The endometrial thickness and endometrial gland density were normal in the FSA extract treated group, while in the COCPs treated group it was atrophied. Decidual-like cells were observed in the COCPs treated group only. Conclusions: Endometrial atrophy and decidual-like cells were noted after COCPs treatment while in the FSA extract and control groups they were absent. The findings suggest that fenugreek seeds could be used as an alternative natural and safe contraceptive product.
format	Conference or Workshop Item
author	Allow, Ahmed Kaid Naji Hellis, Ayah Rebhi Yousef, Zainab Mohamed Bakrim, Norbaiyah Ahmed Kaid, Belqees Saxena, Anil Kumar
author_facet	Allow, Ahmed Kaid Naji Hellis, Ayah Rebhi Yousef, Zainab Mohamed Bakrim, Norbaiyah Ahmed Kaid, Belqees Saxena, Anil Kumar
author_sort	Allow, Ahmed Kaid Naji
title	Histological changes in the uterine of female rats after a comparative treatment with Trigonella foenum-graecum seeds and combined oral contraceptive pills
title_short	Histological changes in the uterine of female rats after a comparative treatment with Trigonella foenum-graecum seeds and combined oral contraceptive pills
title_full	Histological changes in the uterine of female rats after a comparative treatment with Trigonella foenum-graecum seeds and combined oral contraceptive pills
title_fullStr	Histological changes in the uterine of female rats after a comparative treatment with Trigonella foenum-graecum seeds and combined oral contraceptive pills
title_full_unstemmed	Histological changes in the uterine of female rats after a comparative treatment with Trigonella foenum-graecum seeds and combined oral contraceptive pills
title_sort	histological changes in the uterine of female rats after a comparative treatment with trigonella foenum-graecum seeds and combined oral contraceptive pills
publisher	Kulliyyah of Medicine, International Islamic University Malaysia
publishDate	2016
url	http://irep.iium.edu.my/56477/ http://irep.iium.edu.my/56477/ http://irep.iium.edu.my/56477/1/56477_abstract.pdf http://irep.iium.edu.my/56477/2/56477_Histological%20changes-presentation.pdf
first_indexed	2023-09-18T21:19:42Z
last_indexed	2023-09-18T21:19:42Z
_version_	1777411798632235008

Histological changes in the uterine of female rats after a comparative treatment with Trigonella foenum-graecum seeds and combined oral contraceptive pills

Similar Items