Anti-fertility potential of Trigonella foenum-graecum in comparison to oral contraceptive pills
Introduction: This study examines the anti-fertility effects of Trigonella foenumgraecum (fenugreek) seeds extract in the reproductive system of female rats in comparison to combined oral contraceptive pills (COCPs). Methods: Thirty two female Sprague Dawley rats of 8 weeks old were divided into...
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Kulliyyah of Medicine, International Islamic University Malaysia
2015
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| Online Access: | http://irep.iium.edu.my/56476/ http://irep.iium.edu.my/56476/ http://irep.iium.edu.my/56476/1/56476_paper.pdf http://irep.iium.edu.my/56476/2/56476_presentation.pdf |
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iium-564762017-05-04T08:02:37Z http://irep.iium.edu.my/56476/ Anti-fertility potential of Trigonella foenum-graecum in comparison to oral contraceptive pills Allow, Ahmed Kaid Naji Hellis, Ayah Rebhi Yousef, Zainab Mohamed Bakrim, Norbaiyah Ahmed Kaid, Belqees Saxena, Anil Kumar RS Pharmacy and materia medica Introduction: This study examines the anti-fertility effects of Trigonella foenumgraecum (fenugreek) seeds extract in the reproductive system of female rats in comparison to combined oral contraceptive pills (COCPs). Methods: Thirty two female Sprague Dawley rats of 8 weeks old were divided into four groups (A, B, C and D). All female rats were allowed to mate with male rats. Group A is a positive control and not given any treatment. Group B is a negative control group. Group C and D were treated with 0.05 mg/kg body weight of COCPs and 750 mg/kg body weight of fenugreek seed aqueous (FSA) extract for 15 days respectively. Blood samples were subsequently taken on the proestrous phase to evaluate the serum levels of follicular stimulating hormone (FSH). The embryo implantation rate was studied in all groups. Results: Administration of 750 mg/kg FSA extract and COCPs both resulted in decreased FSH serum levels, to 25.62 ng/ml and 71.56 ng/ml respectively (p<0.01). The embryo implantation rate was zero in both FSA extract and COCPs treated groups. Conclusions: Anti-fertility effects of FSA extract and COCPs are potentially similar in terms of their ability to reduce FSH serum levels and inhibit implantation. Kulliyyah of Medicine, International Islamic University Malaysia 2015-12-10 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/56476/1/56476_paper.pdf application/pdf en http://irep.iium.edu.my/56476/2/56476_presentation.pdf Allow, Ahmed Kaid Naji and Hellis, Ayah Rebhi and Yousef, Zainab and Mohamed Bakrim, Norbaiyah and Ahmed Kaid, Belqees and Saxena, Anil Kumar (2015) Anti-fertility potential of Trigonella foenum-graecum in comparison to oral contraceptive pills. In: Medical Research Symposium 2015, 10th Dec. 2015, Kuantan, Pahang. http://iiumedic.net/imjm/v1/download/Volume%2015%20Supplement/MRS2016-ABSTRACT-BOOK-13.pdf |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
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IIUM Repository |
| collection |
Online Access |
| language |
English English |
| topic |
RS Pharmacy and materia medica |
| spellingShingle |
RS Pharmacy and materia medica Allow, Ahmed Kaid Naji Hellis, Ayah Rebhi Yousef, Zainab Mohamed Bakrim, Norbaiyah Ahmed Kaid, Belqees Saxena, Anil Kumar Anti-fertility potential of Trigonella foenum-graecum in comparison to oral contraceptive pills |
| description |
Introduction: This study examines the anti-fertility effects of Trigonella foenumgraecum
(fenugreek) seeds extract in the reproductive system of female rats in comparison to
combined oral contraceptive pills (COCPs). Methods: Thirty two female Sprague Dawley rats
of 8 weeks old were divided into four groups (A, B, C and D). All female rats were allowed to
mate with male rats. Group A is a positive control and not given any treatment. Group B is a
negative control group. Group C and D were treated with 0.05 mg/kg body weight of COCPs
and 750 mg/kg body weight of fenugreek seed aqueous (FSA) extract for 15 days respectively.
Blood samples were subsequently taken on the proestrous phase to evaluate the serum levels
of follicular stimulating hormone (FSH). The embryo implantation rate was studied in all
groups. Results: Administration of 750 mg/kg FSA extract and COCPs both resulted in
decreased FSH serum levels, to 25.62 ng/ml and 71.56 ng/ml respectively (p<0.01). The
embryo implantation rate was zero in both FSA extract and COCPs treated groups.
Conclusions: Anti-fertility effects of FSA extract and COCPs are potentially similar in terms of
their ability to reduce FSH serum levels and inhibit implantation. |
| format |
Conference or Workshop Item |
| author |
Allow, Ahmed Kaid Naji Hellis, Ayah Rebhi Yousef, Zainab Mohamed Bakrim, Norbaiyah Ahmed Kaid, Belqees Saxena, Anil Kumar |
| author_facet |
Allow, Ahmed Kaid Naji Hellis, Ayah Rebhi Yousef, Zainab Mohamed Bakrim, Norbaiyah Ahmed Kaid, Belqees Saxena, Anil Kumar |
| author_sort |
Allow, Ahmed Kaid Naji |
| title |
Anti-fertility potential of Trigonella foenum-graecum in comparison to oral contraceptive pills |
| title_short |
Anti-fertility potential of Trigonella foenum-graecum in comparison to oral contraceptive pills |
| title_full |
Anti-fertility potential of Trigonella foenum-graecum in comparison to oral contraceptive pills |
| title_fullStr |
Anti-fertility potential of Trigonella foenum-graecum in comparison to oral contraceptive pills |
| title_full_unstemmed |
Anti-fertility potential of Trigonella foenum-graecum in comparison to oral contraceptive pills |
| title_sort |
anti-fertility potential of trigonella foenum-graecum in comparison to oral contraceptive pills |
| publisher |
Kulliyyah of Medicine, International Islamic University Malaysia |
| publishDate |
2015 |
| url |
http://irep.iium.edu.my/56476/ http://irep.iium.edu.my/56476/ http://irep.iium.edu.my/56476/1/56476_paper.pdf http://irep.iium.edu.my/56476/2/56476_presentation.pdf |
| first_indexed |
2023-09-18T21:19:41Z |
| last_indexed |
2023-09-18T21:19:41Z |
| _version_ |
1777411798475997184 |