Anti-fertility potential of Trigonella foenum-graecum in comparison to oral contraceptive pills
Introduction: This study examines the anti-fertility effects of Trigonella foenumgraecum (fenugreek) seeds extract in the reproductive system of female rats in comparison to combined oral contraceptive pills (COCPs). Methods: Thirty two female Sprague Dawley rats of 8 weeks old were divided into...
Main Authors: | , , , , , |
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Format: | Conference or Workshop Item |
Language: | English English |
Published: |
Kulliyyah of Medicine, International Islamic University Malaysia
2015
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Subjects: | |
Online Access: | http://irep.iium.edu.my/56476/ http://irep.iium.edu.my/56476/ http://irep.iium.edu.my/56476/1/56476_paper.pdf http://irep.iium.edu.my/56476/2/56476_presentation.pdf |
Summary: | Introduction: This study examines the anti-fertility effects of Trigonella foenumgraecum
(fenugreek) seeds extract in the reproductive system of female rats in comparison to
combined oral contraceptive pills (COCPs). Methods: Thirty two female Sprague Dawley rats
of 8 weeks old were divided into four groups (A, B, C and D). All female rats were allowed to
mate with male rats. Group A is a positive control and not given any treatment. Group B is a
negative control group. Group C and D were treated with 0.05 mg/kg body weight of COCPs
and 750 mg/kg body weight of fenugreek seed aqueous (FSA) extract for 15 days respectively.
Blood samples were subsequently taken on the proestrous phase to evaluate the serum levels
of follicular stimulating hormone (FSH). The embryo implantation rate was studied in all
groups. Results: Administration of 750 mg/kg FSA extract and COCPs both resulted in
decreased FSH serum levels, to 25.62 ng/ml and 71.56 ng/ml respectively (p<0.01). The
embryo implantation rate was zero in both FSA extract and COCPs treated groups.
Conclusions: Anti-fertility effects of FSA extract and COCPs are potentially similar in terms of
their ability to reduce FSH serum levels and inhibit implantation. |
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