PVA-PEG physically cross-linked hydrogel film as a wound dressing: experimental design and optimization

The development of hydrogel films as wound healing dressings is of a great interest owing to their biological tissue-like nature. Polyvinyl alcohol/polyethylene glycol (PVA/PEG) hydrogels loaded with asiaticoside, a standardized rich fraction of Centella asiatica, were successfully developed using...

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Main Authors:	Sh. Ahmad, Afnan, Mandal, Uttam Kumar, Bakhtiar, M. Taher, Darnis, Deny Susanti, Md Jaffri, Juliana
Format:	Article
Language:	English English English English
Published:	Taylor & Francis 2018
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/56468/ http://irep.iium.edu.my/56468/ http://irep.iium.edu.my/56468/ http://irep.iium.edu.my/56468/1/PVA%20PEG%20physically%20cross%20linked%20hydrogel%20film%20as%20a%20wound%20dressing%20experimental%20design%20and%20optimization.pdf http://irep.iium.edu.my/56468/2/iphd_a_1295067_sm0941.pdf http://irep.iium.edu.my/56468/19/56468_PVA%20PEG%20physically%20cross-linked%20hydrogel%20film%20as%20a%20wound%20dressing_scopus.pdf http://irep.iium.edu.my/56468/24/56468%20PVA-PEG%20physically%20cross-linked%20hydrogel%20film%20as%20a%20wound%20dressing_wos.pdf

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spelling	iium-564682019-01-24T07:37:57Z http://irep.iium.edu.my/56468/ PVA-PEG physically cross-linked hydrogel film as a wound dressing: experimental design and optimization Sh. Ahmad, Afnan Mandal, Uttam Kumar Bakhtiar, M. Taher Darnis, Deny Susanti Md Jaffri, Juliana RS Pharmacy and materia medica The development of hydrogel films as wound healing dressings is of a great interest owing to their biological tissue-like nature. Polyvinyl alcohol/polyethylene glycol (PVA/PEG) hydrogels loaded with asiaticoside, a standardized rich fraction of Centella asiatica, were successfully developed using the freeze–thaw method. Response surface methodology with Box–Behnken experimental design was employed to optimize the hydrogels. The hydrogels were characterized and optimized by gel fraction, swelling behavior, water vapor transmission rate and mechanical strength. The formulation with 8% PVA, 5% PEG 400 and five consecutive freeze–thaw cycles was selected as the optimized formulation and was further characterized by its drug release, rheological study, morphology, cytotoxicity and microbial studies. The optimized formulation showed more than 90% drug release at 12 hours. The rheological properties exhibited that the formulation has viscoelastic behavior and remains stable upon storage. Cell culture studies confirmed the biocompatible nature of the optimized hydrogel formulation. In the microbial limit tests, the optimized hydrogel showed no microbial growth. The developed optimized PVA/PEG hydrogel using freeze–thaw method was swellable, elastic, safe, and it can be considered as a promising new wound dressing formulation. Taylor & Francis 2018-09-14 Article PeerReviewed application/pdf en http://irep.iium.edu.my/56468/1/PVA%20PEG%20physically%20cross%20linked%20hydrogel%20film%20as%20a%20wound%20dressing%20experimental%20design%20and%20optimization.pdf application/pdf en http://irep.iium.edu.my/56468/2/iphd_a_1295067_sm0941.pdf application/pdf en http://irep.iium.edu.my/56468/19/56468_PVA%20PEG%20physically%20cross-linked%20hydrogel%20film%20as%20a%20wound%20dressing_scopus.pdf application/pdf en http://irep.iium.edu.my/56468/24/56468%20PVA-PEG%20physically%20cross-linked%20hydrogel%20film%20as%20a%20wound%20dressing_wos.pdf Sh. Ahmad, Afnan and Mandal, Uttam Kumar and Bakhtiar, M. Taher and Darnis, Deny Susanti and Md Jaffri, Juliana (2018) PVA-PEG physically cross-linked hydrogel film as a wound dressing: experimental design and optimization. Pharmaceutical Development and Technology, 23. pp. 751-760. ISSN 1083-7450 E-ISSN 1097-9867 (In Press) http://www.tandfonline.com/doi/abs/10.1080/10837450.2017.1295067?journalCode=iphd20 10.1080/10837450.2017.1295067
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Sh. Ahmad, Afnan Mandal, Uttam Kumar Bakhtiar, M. Taher Darnis, Deny Susanti Md Jaffri, Juliana PVA-PEG physically cross-linked hydrogel film as a wound dressing: experimental design and optimization
description	The development of hydrogel films as wound healing dressings is of a great interest owing to their biological tissue-like nature. Polyvinyl alcohol/polyethylene glycol (PVA/PEG) hydrogels loaded with asiaticoside, a standardized rich fraction of Centella asiatica, were successfully developed using the freeze–thaw method. Response surface methodology with Box–Behnken experimental design was employed to optimize the hydrogels. The hydrogels were characterized and optimized by gel fraction, swelling behavior, water vapor transmission rate and mechanical strength. The formulation with 8% PVA, 5% PEG 400 and five consecutive freeze–thaw cycles was selected as the optimized formulation and was further characterized by its drug release, rheological study, morphology, cytotoxicity and microbial studies. The optimized formulation showed more than 90% drug release at 12 hours. The rheological properties exhibited that the formulation has viscoelastic behavior and remains stable upon storage. Cell culture studies confirmed the biocompatible nature of the optimized hydrogel formulation. In the microbial limit tests, the optimized hydrogel showed no microbial growth. The developed optimized PVA/PEG hydrogel using freeze–thaw method was swellable, elastic, safe, and it can be considered as a promising new wound dressing formulation.
format	Article
author	Sh. Ahmad, Afnan Mandal, Uttam Kumar Bakhtiar, M. Taher Darnis, Deny Susanti Md Jaffri, Juliana
author_facet	Sh. Ahmad, Afnan Mandal, Uttam Kumar Bakhtiar, M. Taher Darnis, Deny Susanti Md Jaffri, Juliana
author_sort	Sh. Ahmad, Afnan
title	PVA-PEG physically cross-linked hydrogel film as a wound dressing: experimental design and optimization
title_short	PVA-PEG physically cross-linked hydrogel film as a wound dressing: experimental design and optimization
title_full	PVA-PEG physically cross-linked hydrogel film as a wound dressing: experimental design and optimization
title_fullStr	PVA-PEG physically cross-linked hydrogel film as a wound dressing: experimental design and optimization
title_full_unstemmed	PVA-PEG physically cross-linked hydrogel film as a wound dressing: experimental design and optimization
title_sort	pva-peg physically cross-linked hydrogel film as a wound dressing: experimental design and optimization
publisher	Taylor & Francis
publishDate	2018
url	http://irep.iium.edu.my/56468/ http://irep.iium.edu.my/56468/ http://irep.iium.edu.my/56468/ http://irep.iium.edu.my/56468/1/PVA%20PEG%20physically%20cross%20linked%20hydrogel%20film%20as%20a%20wound%20dressing%20experimental%20design%20and%20optimization.pdf http://irep.iium.edu.my/56468/2/iphd_a_1295067_sm0941.pdf http://irep.iium.edu.my/56468/19/56468_PVA%20PEG%20physically%20cross-linked%20hydrogel%20film%20as%20a%20wound%20dressing_scopus.pdf http://irep.iium.edu.my/56468/24/56468%20PVA-PEG%20physically%20cross-linked%20hydrogel%20film%20as%20a%20wound%20dressing_wos.pdf
first_indexed	2023-09-18T21:19:41Z
last_indexed	2023-09-18T21:19:41Z
_version_	1777411798041886720

PVA-PEG physically cross-linked hydrogel film as a wound dressing: experimental design and optimization

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