Effects of different types of Syzygium Polyanthum leaves extracts on blood pressure of anaesthetized Spontaneously Hypertensive rats

Background: Syzygium polyanthum leaves are used traditionally for treatment of hypertension. Our previous study showed that S. polyanthum leaves decoction caused significant reduction in blood pressure of Spontaneously Hypertensive rats (SHR) but the bioactive compound(s) is yet unknown. Objective:...

Full description

Bibliographic Details
Main Authors: Ismail, Azlini, Wan Ahmad, Wan Amir Nizam
Format: Conference or Workshop Item
Language:English
Published: 2017
Subjects:
Online Access:http://irep.iium.edu.my/56464/
http://irep.iium.edu.my/56464/1/56464_poster.pdf
id iium-56464
recordtype eprints
spelling iium-564642017-05-04T03:45:41Z http://irep.iium.edu.my/56464/ Effects of different types of Syzygium Polyanthum leaves extracts on blood pressure of anaesthetized Spontaneously Hypertensive rats Ismail, Azlini Wan Ahmad, Wan Amir Nizam Q Science (General) RM300 Drugs and their action RS Pharmacy and materia medica Background: Syzygium polyanthum leaves are used traditionally for treatment of hypertension. Our previous study showed that S. polyanthum leaves decoction caused significant reduction in blood pressure of Spontaneously Hypertensive rats (SHR) but the bioactive compound(s) is yet unknown. Objective: The study aimed to identify the most promising S. polyanthum leaves extract to be subsequently fractionated for the purpose of isolating the bioactive compound(s) responsible for the reduction in blood pressure of SHR. Materials & Methods: SHR rats were anaesthetized using sodium pentobarbital at 60 mg/kg, administered intra-peritonelly. Aqueous (ASP), methanol (MSP), ethyl acetate (EASP) and n-hexane (HSP) extracts of S. polyanthum leaves at increasing doses of 1, 10, 40, and 70 mg/kg were intravenously administered via left jugular vein of SHR (n=6, each group). The changes in hemodynamic parameters including beat-to-beat mean arterial (MAP), systolic (SBP) and diastolic (DBP) blood pressures were recorded through cannulated right main carotid artery using BIOPAC® Recording System. Results: Only EASP, MSP and ASP at doses 40 and 70 mg/kg significantly reduced MAP, SBP and DBP of SHR (P<0.001). Notably, ASP produced the highest reduction in MAP, SBP, and DBP of SHR compared to the other two extracts. However, at the dose of 70 mg/kg, ASP caused sudden drop in blood pressure, and subsequently caused mortality in the tested SHR. Conclusion: It is postulated that the bioactive compound(s) that is(are) responsible for the reduction in blood pressure of SHR by S. polyanthum leaves is(are) polar or semi-polar compound(s). ASP should be fractionated and tested in future experiments. 2017-04-08 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/56464/1/56464_poster.pdf Ismail, Azlini and Wan Ahmad, Wan Amir Nizam (2017) Effects of different types of Syzygium Polyanthum leaves extracts on blood pressure of anaesthetized Spontaneously Hypertensive rats. In: NHAM-CRM Research Track, 8th April 2017, Le Meredian Hotel, Kuala Lumpur. (Unpublished)
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic Q Science (General)
RM300 Drugs and their action
RS Pharmacy and materia medica
spellingShingle Q Science (General)
RM300 Drugs and their action
RS Pharmacy and materia medica
Ismail, Azlini
Wan Ahmad, Wan Amir Nizam
Effects of different types of Syzygium Polyanthum leaves extracts on blood pressure of anaesthetized Spontaneously Hypertensive rats
description Background: Syzygium polyanthum leaves are used traditionally for treatment of hypertension. Our previous study showed that S. polyanthum leaves decoction caused significant reduction in blood pressure of Spontaneously Hypertensive rats (SHR) but the bioactive compound(s) is yet unknown. Objective: The study aimed to identify the most promising S. polyanthum leaves extract to be subsequently fractionated for the purpose of isolating the bioactive compound(s) responsible for the reduction in blood pressure of SHR. Materials & Methods: SHR rats were anaesthetized using sodium pentobarbital at 60 mg/kg, administered intra-peritonelly. Aqueous (ASP), methanol (MSP), ethyl acetate (EASP) and n-hexane (HSP) extracts of S. polyanthum leaves at increasing doses of 1, 10, 40, and 70 mg/kg were intravenously administered via left jugular vein of SHR (n=6, each group). The changes in hemodynamic parameters including beat-to-beat mean arterial (MAP), systolic (SBP) and diastolic (DBP) blood pressures were recorded through cannulated right main carotid artery using BIOPAC® Recording System. Results: Only EASP, MSP and ASP at doses 40 and 70 mg/kg significantly reduced MAP, SBP and DBP of SHR (P<0.001). Notably, ASP produced the highest reduction in MAP, SBP, and DBP of SHR compared to the other two extracts. However, at the dose of 70 mg/kg, ASP caused sudden drop in blood pressure, and subsequently caused mortality in the tested SHR. Conclusion: It is postulated that the bioactive compound(s) that is(are) responsible for the reduction in blood pressure of SHR by S. polyanthum leaves is(are) polar or semi-polar compound(s). ASP should be fractionated and tested in future experiments.
format Conference or Workshop Item
author Ismail, Azlini
Wan Ahmad, Wan Amir Nizam
author_facet Ismail, Azlini
Wan Ahmad, Wan Amir Nizam
author_sort Ismail, Azlini
title Effects of different types of Syzygium Polyanthum leaves extracts on blood pressure of anaesthetized Spontaneously Hypertensive rats
title_short Effects of different types of Syzygium Polyanthum leaves extracts on blood pressure of anaesthetized Spontaneously Hypertensive rats
title_full Effects of different types of Syzygium Polyanthum leaves extracts on blood pressure of anaesthetized Spontaneously Hypertensive rats
title_fullStr Effects of different types of Syzygium Polyanthum leaves extracts on blood pressure of anaesthetized Spontaneously Hypertensive rats
title_full_unstemmed Effects of different types of Syzygium Polyanthum leaves extracts on blood pressure of anaesthetized Spontaneously Hypertensive rats
title_sort effects of different types of syzygium polyanthum leaves extracts on blood pressure of anaesthetized spontaneously hypertensive rats
publishDate 2017
url http://irep.iium.edu.my/56464/
http://irep.iium.edu.my/56464/1/56464_poster.pdf
first_indexed 2023-09-18T21:19:40Z
last_indexed 2023-09-18T21:19:40Z
_version_ 1777411797469364224