Low inhibition of alpha-glucosidase and xanthine oxidase activities of ethanol extract of Momordica charantia fruit
Objective: To evaluate the α-glucosidase and xanthine oxidase inhibitory activities of different ethanolic and aqueous extracts of Momordica charantia fruit. Materials and Methods: The M. charantia fruits were extracted using different concentrations of ethanol in water (0, 20, 40, 60, 80 and 100...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Wolters Kluwer - Medknow Publications Wolters Kluwer India Pvt. Ltd.
2017
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/56455/ http://irep.iium.edu.my/56455/ http://irep.iium.edu.my/56455/7/56455-Low%20inhibition%20of%20alpha-glucosidase.pdf http://irep.iium.edu.my/56455/8/56455-Low%20inhibition%20of%20alpha-glucosidase_SCOPUS.pdf |
| Summary: | Objective: To evaluate the α-glucosidase and xanthine oxidase inhibitory activities of
different ethanolic and aqueous extracts of Momordica charantia fruit. Materials and
Methods: The M. charantia fruits were extracted using different concentrations of ethanol
in water (0, 20, 40, 60, 80 and 100 %, v/v). The samples from different ethanolic and
aqueous extracts of M. charantia fruit (0, 20, 40, 60 and 100 % ethanol in water [v/v]
extracts) were tested for α-glucosidase and xanthine oxidase inhibitory activities. Quercetin
and allopurinol were used as positive controls for α-glucosidase and xanthine oxidase
inhibitory assay, respectively. The samples were also tested for phytochemicals screening
such as alkaloid, phenol, steroid, tannin, coumarins and flavonoid. The significant difference
was determined by one-way ANOVA test with a Tukey comparison at confidence interval
of 95%. Results: Phytochemical screening showed the presence of coumarin, alkaloid,
steroid and phenol in the extracts. The six different M. charantia extracts showed low
inhibition on α-glucosidase and xanthine oxidase activities. Conclusions: The antidiabetic
activity of the ethanolic and aqueous extracts of M. charantia fruit was not through the
inhibition of α-glucosidase and xanthine oxidase. |
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