Live birth rates are satisfactory following multiple IVF treatment cycles in poor prognosis patients
This seven-year retrospective study analysed the live birth rate (LBR) for women undergoing IVF treatment with various antral follicle counts (AFC). The LBR decreased with lower AFC ratings, and in 290 treatment cycles for women in the poorest AFC category, �4 follicles (group E), the LBR was the...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English English English |
| Published: |
Elsevier
2017
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/56322/ http://irep.iium.edu.my/56322/ http://irep.iium.edu.my/56322/1/live%20birth%20rates-%20Dr%20kamarulbahyah.pdf http://irep.iium.edu.my/56322/7/56322-Live%20birth%20rates%20are%20satisfactory%20following%20multiple%20IVF%20treatment%20cycles%20_SCOPUS.pdf http://irep.iium.edu.my/56322/8/56322-Live%20birth%20rates%20are%20satisfactory%20following%20multiple%20IVF%20treatment%20cycles%20_WOS.pdf |
| Summary: | This seven-year retrospective study analysed the live birth rate (LBR) for women undergoing IVF
treatment with various antral follicle counts (AFC). The LBR decreased with lower AFC ratings, and in 290
treatment cycles for women in the poorest AFC category, �4 follicles (group E), the LBR was the lowest at
10.7%. The pregnancy loss rate (PLR) significantly increased with poorer AFC categories, from 21.8% in AFC
group A (20 follicles), to 54.4% in AFC group E (p < 0.0001). This trend was repeated with advancing age,
from 21.6% for younger women ( < 35 years), to 32.9, 48.5 and 100% for ages 35–39, 40–44 and 45 years,
respectively (p < 0.0001). However, LBR within the specific AFC group E cohort was also age-dependent
and decreased significantly from 30.0% for <35 years old, to 13.3, 3.9 and 0% for patients aged 35–39, 40–
44 and 45 years, respectively. Most, importantly, LBR rates within these age groups were not dependent
on the number of IVF attempts (1st, 2nd, 3rd or 4 cycles), which indicated that cycle number should not
be the primary deciding factor for cessation of IVF treatment in responding women <45years old. |
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