Incorporation of natural wound healer (honey) into hydrogel

Hydrogels possess an exceptional three-dimensional cross linked networks of hydrophilic polymers that able to imbibe a large proportion of water while maintaining the structure. For hydrogel mixture, 10% polyvinyl alcohol (PVA) and 1% polyethylene glycol (PEG) were used. This was mixed with 1% prote...

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Main Authors:	Ab. Hadi, Hazrina, Abdul Jalil, Mohd Azri, Kasmuri, Abdul Razak
Format:	Conference or Workshop Item
Language:	English
Published:	2017
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/56164/ http://irep.iium.edu.my/56164/22/56164.pdf

id	iium-56164
recordtype	eprints
spelling	iium-561642017-04-18T07:00:30Z http://irep.iium.edu.my/56164/ Incorporation of natural wound healer (honey) into hydrogel Ab. Hadi, Hazrina Abdul Jalil, Mohd Azri Kasmuri, Abdul Razak RS Pharmacy and materia medica Hydrogels possess an exceptional three-dimensional cross linked networks of hydrophilic polymers that able to imbibe a large proportion of water while maintaining the structure. For hydrogel mixture, 10% polyvinyl alcohol (PVA) and 1% polyethylene glycol (PEG) were used. This was mixed with 1% protein-free agar solution (w/v), and 2% dextran (w/v). When the temperature reached 45°C, 6% honey (v/v) of honey was added. For a control hydrogel, similar mixture was prepared with the exclusion of honey. They were frozen at −20°C for 18 h and then thawed at 25°C for 6 h to complete a cycle (F-T cycle). The pieces of hydrogel samples (2×2 cm) were dried at 60°C in the oven for 12 hours (Wa). Then, they were soaked in pH 7.4 phosphate buffer solution (PBS) and put inside the oven at 37°C (Ws) for 24 hours. The swelling ratio (SR) was calculated accordingly. Meanwhile, the gel fraction was determined by drying hydrogel samples (2×2 cm) for 6 h at 50°C in the oven (Wo). They were soaked in 10 mL distilled water into Petri dishes for 24 hour up to a constant weight and taken out from Petri dishes in order to remove the soluble parts. The gels were dried again at 50°C under vacuum (We). For the swelling ratio test, hydrogels that were lowly cross-linked showed a higher water uptake since a highly cross-linked structure unable to preserve much water in its structure. Formulation containing honey showed lower swelling ability, compared to control. It can be postulated by the present of agar that can hinder its swelling ability. Since there is no active ingredient (honey) in control formulation, the gel fraction of the hydrogel is highest indicating that the PVA in this formulation was almost completely cross-linked. Hence, honey concentration could be used to control the strength and increase the flexibility the hydrogel. In conclusion, hydrogel with 10% honey concentration demonstrated low swelling index but better flexibility than the control formulation. 2017 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/56164/22/56164.pdf Ab. Hadi, Hazrina and Abdul Jalil, Mohd Azri and Kasmuri, Abdul Razak (2017) Incorporation of natural wound healer (honey) into hydrogel. In: The JSPS-NRCT Follow-Up Seminar 2017 and 33rd International Annual Meeting in Pharmaceutical Sciences (JSPS-NRCT 2017 and IAMPS33), 2nd-3rd March 2017, Bangkok, Thailand. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Ab. Hadi, Hazrina Abdul Jalil, Mohd Azri Kasmuri, Abdul Razak Incorporation of natural wound healer (honey) into hydrogel
description	Hydrogels possess an exceptional three-dimensional cross linked networks of hydrophilic polymers that able to imbibe a large proportion of water while maintaining the structure. For hydrogel mixture, 10% polyvinyl alcohol (PVA) and 1% polyethylene glycol (PEG) were used. This was mixed with 1% protein-free agar solution (w/v), and 2% dextran (w/v). When the temperature reached 45°C, 6% honey (v/v) of honey was added. For a control hydrogel, similar mixture was prepared with the exclusion of honey. They were frozen at −20°C for 18 h and then thawed at 25°C for 6 h to complete a cycle (F-T cycle). The pieces of hydrogel samples (2×2 cm) were dried at 60°C in the oven for 12 hours (Wa). Then, they were soaked in pH 7.4 phosphate buffer solution (PBS) and put inside the oven at 37°C (Ws) for 24 hours. The swelling ratio (SR) was calculated accordingly. Meanwhile, the gel fraction was determined by drying hydrogel samples (2×2 cm) for 6 h at 50°C in the oven (Wo). They were soaked in 10 mL distilled water into Petri dishes for 24 hour up to a constant weight and taken out from Petri dishes in order to remove the soluble parts. The gels were dried again at 50°C under vacuum (We). For the swelling ratio test, hydrogels that were lowly cross-linked showed a higher water uptake since a highly cross-linked structure unable to preserve much water in its structure. Formulation containing honey showed lower swelling ability, compared to control. It can be postulated by the present of agar that can hinder its swelling ability. Since there is no active ingredient (honey) in control formulation, the gel fraction of the hydrogel is highest indicating that the PVA in this formulation was almost completely cross-linked. Hence, honey concentration could be used to control the strength and increase the flexibility the hydrogel. In conclusion, hydrogel with 10% honey concentration demonstrated low swelling index but better flexibility than the control formulation.
format	Conference or Workshop Item
author	Ab. Hadi, Hazrina Abdul Jalil, Mohd Azri Kasmuri, Abdul Razak
author_facet	Ab. Hadi, Hazrina Abdul Jalil, Mohd Azri Kasmuri, Abdul Razak
author_sort	Ab. Hadi, Hazrina
title	Incorporation of natural wound healer (honey) into hydrogel
title_short	Incorporation of natural wound healer (honey) into hydrogel
title_full	Incorporation of natural wound healer (honey) into hydrogel
title_fullStr	Incorporation of natural wound healer (honey) into hydrogel
title_full_unstemmed	Incorporation of natural wound healer (honey) into hydrogel
title_sort	incorporation of natural wound healer (honey) into hydrogel
publishDate	2017
url	http://irep.iium.edu.my/56164/ http://irep.iium.edu.my/56164/22/56164.pdf
first_indexed	2023-09-18T21:19:15Z
last_indexed	2023-09-18T21:19:15Z
_version_	1777411770589118464

Incorporation of natural wound healer (honey) into hydrogel

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