Venomics and pharmacological activities of Malaysian kraits : bungarus candidus and bungarus fasciatus

Bungarus candidus (Malayan krait) and Bungarus fasciatus (Banded krait) are two medically important elapid species found in Southeast Asia countries. The reported cases of envenoming by Bungarus candidus and Bungarus fasciatus are limited with very limited data available. The venom of these species...

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Main Authors:	Othman, Iekhsan, Ahmad Rusmili, Muhamad Rusdi
Format:	Conference or Workshop Item
Language:	English
Published:	Idaman Pharma Sdn. Bhd. 2016
Subjects:	QH Natural history QL Zoology RS Pharmacy and materia medica RZ Other systems of medicine
Online Access:	http://irep.iium.edu.my/56083/ http://irep.iium.edu.my/56083/ http://irep.iium.edu.my/56083/13/AMSEM%2020_complete_new.pdf

id	iium-56083
recordtype	eprints
spelling	iium-560832017-03-23T06:39:23Z http://irep.iium.edu.my/56083/ Venomics and pharmacological activities of Malaysian kraits : bungarus candidus and bungarus fasciatus Othman, Iekhsan Ahmad Rusmili, Muhamad Rusdi QH Natural history QL Zoology RS Pharmacy and materia medica RZ Other systems of medicine Bungarus candidus (Malayan krait) and Bungarus fasciatus (Banded krait) are two medically important elapid species found in Southeast Asia countries. The reported cases of envenoming by Bungarus candidus and Bungarus fasciatus are limited with very limited data available. The venom of these species has been known to contain highly potent presynaptic (β- neurotoxins) and postsynaptic (α-neurotoxins) neurotoxins which prevent the acetylcholine release and receptor binding, respectively at the neuromuscular junction. The venom from both species contain complex mixture of a myriad of toxins that are yet to be discovered and characterized. Recent case reports and studies, have indicated that the activities of the venoms are not limited to neurotoxic activity only but could contribute to other lethal activity that affect other major organs. Furthermore, the venoms could have geographical variation as they are widely distributed throughout Southeast Asia. The variation in their venom will definitely affect the effectiveness of the available antivenom and the overall success in managing envenoming. This paper will highlight the works that have been conducted on the Malaysian Bungarus candidus and Bungarus fasciatus venom and toxins using isolated tissue preparation and proteomic techniques. The future direction of the Bungarus candidus and Bungarus fasciatus venom research, its importance in the management of krait envenoming and potential in bioprospecting for novel therapeutics and biomedical research tools will be discussed. In addition, the need for better and systematic krait bite case reporting will be emphasized. This study also explore the diversity of different molecules for bioprospecting, allowing more applied research to be conducted in the future. Idaman Pharma Sdn. Bhd. 2016-11 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/56083/13/AMSEM%2020_complete_new.pdf Othman, Iekhsan and Ahmad Rusmili, Muhamad Rusdi (2016) Venomics and pharmacological activities of Malaysian kraits : bungarus candidus and bungarus fasciatus. In: ASEAN Marine Animals & Snake Envenoming (Poisoning) Management : the 4th International Symposium, 28 November - 1 December 2016, Universiti Sains Malaysia, Pualau Pinang.. http://mstamsem.blogspot.my/p/abstract.html
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QH Natural history QL Zoology RS Pharmacy and materia medica RZ Other systems of medicine
spellingShingle	QH Natural history QL Zoology RS Pharmacy and materia medica RZ Other systems of medicine Othman, Iekhsan Ahmad Rusmili, Muhamad Rusdi Venomics and pharmacological activities of Malaysian kraits : bungarus candidus and bungarus fasciatus
description	Bungarus candidus (Malayan krait) and Bungarus fasciatus (Banded krait) are two medically important elapid species found in Southeast Asia countries. The reported cases of envenoming by Bungarus candidus and Bungarus fasciatus are limited with very limited data available. The venom of these species has been known to contain highly potent presynaptic (β- neurotoxins) and postsynaptic (α-neurotoxins) neurotoxins which prevent the acetylcholine release and receptor binding, respectively at the neuromuscular junction. The venom from both species contain complex mixture of a myriad of toxins that are yet to be discovered and characterized. Recent case reports and studies, have indicated that the activities of the venoms are not limited to neurotoxic activity only but could contribute to other lethal activity that affect other major organs. Furthermore, the venoms could have geographical variation as they are widely distributed throughout Southeast Asia. The variation in their venom will definitely affect the effectiveness of the available antivenom and the overall success in managing envenoming. This paper will highlight the works that have been conducted on the Malaysian Bungarus candidus and Bungarus fasciatus venom and toxins using isolated tissue preparation and proteomic techniques. The future direction of the Bungarus candidus and Bungarus fasciatus venom research, its importance in the management of krait envenoming and potential in bioprospecting for novel therapeutics and biomedical research tools will be discussed. In addition, the need for better and systematic krait bite case reporting will be emphasized. This study also explore the diversity of different molecules for bioprospecting, allowing more applied research to be conducted in the future.
format	Conference or Workshop Item
author	Othman, Iekhsan Ahmad Rusmili, Muhamad Rusdi
author_facet	Othman, Iekhsan Ahmad Rusmili, Muhamad Rusdi
author_sort	Othman, Iekhsan
title	Venomics and pharmacological activities of Malaysian kraits : bungarus candidus and bungarus fasciatus
title_short	Venomics and pharmacological activities of Malaysian kraits : bungarus candidus and bungarus fasciatus
title_full	Venomics and pharmacological activities of Malaysian kraits : bungarus candidus and bungarus fasciatus
title_fullStr	Venomics and pharmacological activities of Malaysian kraits : bungarus candidus and bungarus fasciatus
title_full_unstemmed	Venomics and pharmacological activities of Malaysian kraits : bungarus candidus and bungarus fasciatus
title_sort	venomics and pharmacological activities of malaysian kraits : bungarus candidus and bungarus fasciatus
publisher	Idaman Pharma Sdn. Bhd.
publishDate	2016
url	http://irep.iium.edu.my/56083/ http://irep.iium.edu.my/56083/ http://irep.iium.edu.my/56083/13/AMSEM%2020_complete_new.pdf
first_indexed	2023-09-18T21:19:08Z
last_indexed	2023-09-18T21:19:08Z
_version_	1777411763208192000

Venomics and pharmacological activities of Malaysian kraits : bungarus candidus and bungarus fasciatus

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