Antibiotic dosing for multidrug-resistant pathogen pneumonia

Purpose of review Nosocomial pneumonia caused by multidrug-resistant pathogens is increasing in the ICU, and these infections are negatively associated with patient outcomes. Optimization of antibiotic dosing has been suggested as a key intervention to improve clinical outcomes in patients with noso...

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Main Authors:	Abdul Aziz, Mohd. Hafiz, Lipman, Jeffrey, Roberts, Jason A.
Format:	Article
Language:	English English
Published:	Lippincott Williams & Wilkins (LWW) 2017
Subjects:	R Medicine (General) RM Therapeutics. Pharmacology RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/56003/ http://irep.iium.edu.my/56003/ http://irep.iium.edu.my/56003/ http://irep.iium.edu.my/56003/1/56603_Antibiotic%20dosing%20for%20multidrug-resistant%20pathogen%20pneumonia.pdf http://irep.iium.edu.my/56003/13/56003_Antibiotic%20dosing%20for%20multidrug-resistant%20pathogen%20pneumonia_SCOPUS.pdf

id	iium-56003
recordtype	eprints
spelling	iium-560032018-04-02T23:58:40Z http://irep.iium.edu.my/56003/ Antibiotic dosing for multidrug-resistant pathogen pneumonia Abdul Aziz, Mohd. Hafiz Lipman, Jeffrey Roberts, Jason A. R Medicine (General) RM Therapeutics. Pharmacology RS Pharmacy and materia medica Purpose of review Nosocomial pneumonia caused by multidrug-resistant pathogens is increasing in the ICU, and these infections are negatively associated with patient outcomes. Optimization of antibiotic dosing has been suggested as a key intervention to improve clinical outcomes in patients with nosocomial pneumonia. This review describes the recent pharmacokinetic/pharmacodynamic data relevant to antibiotic dosing for nosocomial pneumonia caused by multidrug-resistant pathogens. Recent findings Optimal antibiotic treatment is challenging in critically ill patients with nosocomial pneumonia; most dosing guidelines do not consider the altered physiology and illness severity associated with severe lung infections. Antibiotic dosing can be guided by plasma drug concentrations, which do not reflect the concentrations at the site of infection. The application of aggressive dosing regimens, in accordance to the antibiotic's pharmacokinetic/pharmacodynamic characteristics, may be required to ensure rapid and effective drug exposure in infected lung tissues. Summary Conventional antibiotic dosing increases the likelihood of therapeutic failure in critically ill patients with nosocomial pneumonia. Alternative dosing strategies, which exploit the pharmacokinetic/ pharmacodynamic properties of an antibiotic, should be strongly considered to ensure optimal antibiotic exposure and better therapeutic outcomes in these patients. © 2017 Wolters Kluwer Health, Inc. Lippincott Williams & Wilkins (LWW) 2017-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/56003/1/56603_Antibiotic%20dosing%20for%20multidrug-resistant%20pathogen%20pneumonia.pdf application/pdf en http://irep.iium.edu.my/56003/13/56003_Antibiotic%20dosing%20for%20multidrug-resistant%20pathogen%20pneumonia_SCOPUS.pdf Abdul Aziz, Mohd. Hafiz and Lipman, Jeffrey and Roberts, Jason A. (2017) Antibiotic dosing for multidrug-resistant pathogen pneumonia. Current Opinion in Infectious Diseases, 30 (2). pp. 231-239. ISSN 0951-7375 E-ISSN 1473-6527 https://www.ncbi.nlm.nih.gov/pubmed/28030371 10.1097/QCO.0000000000000348
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General) RM Therapeutics. Pharmacology RS Pharmacy and materia medica
spellingShingle	R Medicine (General) RM Therapeutics. Pharmacology RS Pharmacy and materia medica Abdul Aziz, Mohd. Hafiz Lipman, Jeffrey Roberts, Jason A. Antibiotic dosing for multidrug-resistant pathogen pneumonia
description	Purpose of review Nosocomial pneumonia caused by multidrug-resistant pathogens is increasing in the ICU, and these infections are negatively associated with patient outcomes. Optimization of antibiotic dosing has been suggested as a key intervention to improve clinical outcomes in patients with nosocomial pneumonia. This review describes the recent pharmacokinetic/pharmacodynamic data relevant to antibiotic dosing for nosocomial pneumonia caused by multidrug-resistant pathogens. Recent findings Optimal antibiotic treatment is challenging in critically ill patients with nosocomial pneumonia; most dosing guidelines do not consider the altered physiology and illness severity associated with severe lung infections. Antibiotic dosing can be guided by plasma drug concentrations, which do not reflect the concentrations at the site of infection. The application of aggressive dosing regimens, in accordance to the antibiotic's pharmacokinetic/pharmacodynamic characteristics, may be required to ensure rapid and effective drug exposure in infected lung tissues. Summary Conventional antibiotic dosing increases the likelihood of therapeutic failure in critically ill patients with nosocomial pneumonia. Alternative dosing strategies, which exploit the pharmacokinetic/ pharmacodynamic properties of an antibiotic, should be strongly considered to ensure optimal antibiotic exposure and better therapeutic outcomes in these patients. © 2017 Wolters Kluwer Health, Inc.
format	Article
author	Abdul Aziz, Mohd. Hafiz Lipman, Jeffrey Roberts, Jason A.
author_facet	Abdul Aziz, Mohd. Hafiz Lipman, Jeffrey Roberts, Jason A.
author_sort	Abdul Aziz, Mohd. Hafiz
title	Antibiotic dosing for multidrug-resistant pathogen pneumonia
title_short	Antibiotic dosing for multidrug-resistant pathogen pneumonia
title_full	Antibiotic dosing for multidrug-resistant pathogen pneumonia
title_fullStr	Antibiotic dosing for multidrug-resistant pathogen pneumonia
title_full_unstemmed	Antibiotic dosing for multidrug-resistant pathogen pneumonia
title_sort	antibiotic dosing for multidrug-resistant pathogen pneumonia
publisher	Lippincott Williams & Wilkins (LWW)
publishDate	2017
url	http://irep.iium.edu.my/56003/ http://irep.iium.edu.my/56003/ http://irep.iium.edu.my/56003/ http://irep.iium.edu.my/56003/1/56603_Antibiotic%20dosing%20for%20multidrug-resistant%20pathogen%20pneumonia.pdf http://irep.iium.edu.my/56003/13/56003_Antibiotic%20dosing%20for%20multidrug-resistant%20pathogen%20pneumonia_SCOPUS.pdf
first_indexed	2023-09-18T21:19:02Z
last_indexed	2023-09-18T21:19:02Z
_version_	1777411757141131264

Antibiotic dosing for multidrug-resistant pathogen pneumonia

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