Nephrotoxicity in chronic low dose organophosphate exposure

Objectives: People are exposed to chronic low dose organophosphates (OPs) pesticides through agriculture and pest control activities. Apparently, there were signifcant epidemiological reports suggesting pesticides role in chronic kidney disease. This observation is yet to be confrmed with appropri...

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Main Authors:	Aung, Sanda, Abdullah, Nor Zamzila, A.Talib, Norlelawati, Mohd Noor, Noriah, Harun, Norra, Mat Zainone, Zamzuria, Abdul Razak, Tariq
Format:	Article
Language:	English
Published:	College of Pathologists, Academy of Medicine Malaysia 2016
Subjects:	RB Pathology
Online Access:	http://irep.iium.edu.my/55903/ http://irep.iium.edu.my/55903/ http://irep.iium.edu.my/55903/12/55903-Nephrotoxicity%20in%20chronic%20low%20dose%20organophosphate%20exposure.pdf

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recordtype	eprints
spelling	iium-559032017-10-17T02:51:37Z http://irep.iium.edu.my/55903/ Nephrotoxicity in chronic low dose organophosphate exposure Aung, Sanda Abdullah, Nor Zamzila A.Talib, Norlelawati Mohd Noor, Noriah Harun, Norra Mat Zainone, Zamzuria Abdul Razak, Tariq RB Pathology Objectives: People are exposed to chronic low dose organophosphates (OPs) pesticides through agriculture and pest control activities. Apparently, there were signifcant epidemiological reports suggesting pesticides role in chronic kidney disease. This observation is yet to be confrmed with appropriate experimental model of chronic OPs exposure on animals. Thus, the aim of this study is to observe for histomorphological characteristics related to nephropathy in the kidneys of rats upon exposure to chronic low dose OPs. Materials and Methods: 24 males Sprague-Dawley rats were randomly divided into 3 groups of 6 rats each with Group 1 as a Control group, whilst Group 2 and Group 3 received subcutaneous vehicle (3% dimethyl sulphoxide + 97% v/v soy oil) and 18.0 mg/kg BW chlorpyrifos respectively, every other day for 180 days. After treatment, the rats were sacrifced and the right kidney was subjected to routine H&E examination and specifc Masson-Trichrome and periodic-acid Schiff stain. Results: OPs exposed group (Group 3) exhibited signifcant histo-morphological abnormalities suggesting cell injury, apoptosis and degenerative changes in glomeruli and tubules. In contrast, the control groups 1 and 2 (vehicle) are spared. Conclusion: Chronic low dose OPs exposure induced nephrotoxicity. The exact mechanism of nephrotoxicity should be further investigated. College of Pathologists, Academy of Medicine Malaysia 2016-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/55903/12/55903-Nephrotoxicity%20in%20chronic%20low%20dose%20organophosphate%20exposure.pdf Aung, Sanda and Abdullah, Nor Zamzila and A.Talib, Norlelawati and Mohd Noor, Noriah and Harun, Norra and Mat Zainone, Zamzuria and Abdul Razak, Tariq (2016) Nephrotoxicity in chronic low dose organophosphate exposure. The Malaysian Journal of Pathology, 38 (2). p. 193. ISSN 0126-8635 http://www.mjpath.org.my/2016/v38n2/abstracts.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RB Pathology
spellingShingle	RB Pathology Aung, Sanda Abdullah, Nor Zamzila A.Talib, Norlelawati Mohd Noor, Noriah Harun, Norra Mat Zainone, Zamzuria Abdul Razak, Tariq Nephrotoxicity in chronic low dose organophosphate exposure
description	Objectives: People are exposed to chronic low dose organophosphates (OPs) pesticides through agriculture and pest control activities. Apparently, there were signifcant epidemiological reports suggesting pesticides role in chronic kidney disease. This observation is yet to be confrmed with appropriate experimental model of chronic OPs exposure on animals. Thus, the aim of this study is to observe for histomorphological characteristics related to nephropathy in the kidneys of rats upon exposure to chronic low dose OPs. Materials and Methods: 24 males Sprague-Dawley rats were randomly divided into 3 groups of 6 rats each with Group 1 as a Control group, whilst Group 2 and Group 3 received subcutaneous vehicle (3% dimethyl sulphoxide + 97% v/v soy oil) and 18.0 mg/kg BW chlorpyrifos respectively, every other day for 180 days. After treatment, the rats were sacrifced and the right kidney was subjected to routine H&E examination and specifc Masson-Trichrome and periodic-acid Schiff stain. Results: OPs exposed group (Group 3) exhibited signifcant histo-morphological abnormalities suggesting cell injury, apoptosis and degenerative changes in glomeruli and tubules. In contrast, the control groups 1 and 2 (vehicle) are spared. Conclusion: Chronic low dose OPs exposure induced nephrotoxicity. The exact mechanism of nephrotoxicity should be further investigated.
format	Article
author	Aung, Sanda Abdullah, Nor Zamzila A.Talib, Norlelawati Mohd Noor, Noriah Harun, Norra Mat Zainone, Zamzuria Abdul Razak, Tariq
author_facet	Aung, Sanda Abdullah, Nor Zamzila A.Talib, Norlelawati Mohd Noor, Noriah Harun, Norra Mat Zainone, Zamzuria Abdul Razak, Tariq
author_sort	Aung, Sanda
title	Nephrotoxicity in chronic low dose organophosphate exposure
title_short	Nephrotoxicity in chronic low dose organophosphate exposure
title_full	Nephrotoxicity in chronic low dose organophosphate exposure
title_fullStr	Nephrotoxicity in chronic low dose organophosphate exposure
title_full_unstemmed	Nephrotoxicity in chronic low dose organophosphate exposure
title_sort	nephrotoxicity in chronic low dose organophosphate exposure
publisher	College of Pathologists, Academy of Medicine Malaysia
publishDate	2016
url	http://irep.iium.edu.my/55903/ http://irep.iium.edu.my/55903/ http://irep.iium.edu.my/55903/12/55903-Nephrotoxicity%20in%20chronic%20low%20dose%20organophosphate%20exposure.pdf
first_indexed	2023-09-18T21:18:52Z
last_indexed	2023-09-18T21:18:52Z
_version_	1777411747153444864

Nephrotoxicity in chronic low dose organophosphate exposure

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