Fabrication, characterization and in vitro biocompatibility of electrospun hydroxyethyl cellulose/poly (vinyl) alcohol nanofibrous composite biomaterial for bone tissue engineering

Development of novel scaffold materials that mimic the extracellular matrix, architecturally and functionally, is becoming highly important to meet the demands of the advances in bone tissue engineering. This paper reports, the fabrication of natural polymer cellulose derived hydroxyethyl cellulose...

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Main Authors:	Chahal, Sugandha, Jahir Hussain, Fathima Shahitha, Anuj, Kumar, Abdull Rasad, Mohammad Syaiful Bahari, Mohd Yusoff, Mashitah
Format:	Article
Language:	English
Published:	Elsevier 2016
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/55747/ http://irep.iium.edu.my/55747/ http://irep.iium.edu.my/55747/1/CES%202016.pdf

id	iium-55747
recordtype	eprints
spelling	iium-557472017-02-28T17:19:12Z http://irep.iium.edu.my/55747/ Fabrication, characterization and in vitro biocompatibility of electrospun hydroxyethyl cellulose/poly (vinyl) alcohol nanofibrous composite biomaterial for bone tissue engineering Chahal, Sugandha Jahir Hussain, Fathima Shahitha Anuj, Kumar Abdull Rasad, Mohammad Syaiful Bahari Mohd Yusoff, Mashitah Q Science (General) Development of novel scaffold materials that mimic the extracellular matrix, architecturally and functionally, is becoming highly important to meet the demands of the advances in bone tissue engineering. This paper reports, the fabrication of natural polymer cellulose derived hydroxyethyl cellulose (HEC) based nanostructured scaffolds with uniform fiber morphology through electrospinning. Poly (vinyl alcohol) (PVA) was used as an ionic solvent for supporting the electrospinning of HEC. Scanning electron microscopy and ImageJ analysis revealed the formation of non-woven nanofibers with well-defined porous architecture. The interactions between HEC and PVA in the electrospun nanofibers were studied by differential scanning calorimetry, X-ray diffraction, dynamic mechanical analysis thermo-gravimetric analysis; Fourier transform-infrared spectroscopy, X-ray photoelectron spectroscopy and tensile test. The mechanical properties of scaffolds were significantly altered with different ratios of HEC/PVA. Further, the biocompatibility of HEC/PVA scaffolds was evaluated using human osteosarcoma cells. The SEM images revealed favorable cells attachment and spreading on the nanofibrous scaffolds and MTS assay showed increased cell proliferation after different time periods. Thus, these results indicate that HEC based nanofibrous scaffolds will be a promising candidate for bone tissue engineering. Elsevier 2016 Article PeerReviewed application/pdf en http://irep.iium.edu.my/55747/1/CES%202016.pdf Chahal, Sugandha and Jahir Hussain, Fathima Shahitha and Anuj, Kumar and Abdull Rasad, Mohammad Syaiful Bahari and Mohd Yusoff, Mashitah (2016) Fabrication, characterization and in vitro biocompatibility of electrospun hydroxyethyl cellulose/poly (vinyl) alcohol nanofibrous composite biomaterial for bone tissue engineering. Chemical Engineering Science, 144. pp. 17-29. ISSN 0009-2509 https://www.journals.elsevier.com/chemical-engineering-science/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Chahal, Sugandha Jahir Hussain, Fathima Shahitha Anuj, Kumar Abdull Rasad, Mohammad Syaiful Bahari Mohd Yusoff, Mashitah Fabrication, characterization and in vitro biocompatibility of electrospun hydroxyethyl cellulose/poly (vinyl) alcohol nanofibrous composite biomaterial for bone tissue engineering
description	Development of novel scaffold materials that mimic the extracellular matrix, architecturally and functionally, is becoming highly important to meet the demands of the advances in bone tissue engineering. This paper reports, the fabrication of natural polymer cellulose derived hydroxyethyl cellulose (HEC) based nanostructured scaffolds with uniform fiber morphology through electrospinning. Poly (vinyl alcohol) (PVA) was used as an ionic solvent for supporting the electrospinning of HEC. Scanning electron microscopy and ImageJ analysis revealed the formation of non-woven nanofibers with well-defined porous architecture. The interactions between HEC and PVA in the electrospun nanofibers were studied by differential scanning calorimetry, X-ray diffraction, dynamic mechanical analysis thermo-gravimetric analysis; Fourier transform-infrared spectroscopy, X-ray photoelectron spectroscopy and tensile test. The mechanical properties of scaffolds were significantly altered with different ratios of HEC/PVA. Further, the biocompatibility of HEC/PVA scaffolds was evaluated using human osteosarcoma cells. The SEM images revealed favorable cells attachment and spreading on the nanofibrous scaffolds and MTS assay showed increased cell proliferation after different time periods. Thus, these results indicate that HEC based nanofibrous scaffolds will be a promising candidate for bone tissue engineering.
format	Article
author	Chahal, Sugandha Jahir Hussain, Fathima Shahitha Anuj, Kumar Abdull Rasad, Mohammad Syaiful Bahari Mohd Yusoff, Mashitah
author_facet	Chahal, Sugandha Jahir Hussain, Fathima Shahitha Anuj, Kumar Abdull Rasad, Mohammad Syaiful Bahari Mohd Yusoff, Mashitah
author_sort	Chahal, Sugandha
title	Fabrication, characterization and in vitro biocompatibility of electrospun hydroxyethyl cellulose/poly (vinyl) alcohol nanofibrous composite biomaterial for bone tissue engineering
title_short	Fabrication, characterization and in vitro biocompatibility of electrospun hydroxyethyl cellulose/poly (vinyl) alcohol nanofibrous composite biomaterial for bone tissue engineering
title_full	Fabrication, characterization and in vitro biocompatibility of electrospun hydroxyethyl cellulose/poly (vinyl) alcohol nanofibrous composite biomaterial for bone tissue engineering
title_fullStr	Fabrication, characterization and in vitro biocompatibility of electrospun hydroxyethyl cellulose/poly (vinyl) alcohol nanofibrous composite biomaterial for bone tissue engineering
title_full_unstemmed	Fabrication, characterization and in vitro biocompatibility of electrospun hydroxyethyl cellulose/poly (vinyl) alcohol nanofibrous composite biomaterial for bone tissue engineering
title_sort	fabrication, characterization and in vitro biocompatibility of electrospun hydroxyethyl cellulose/poly (vinyl) alcohol nanofibrous composite biomaterial for bone tissue engineering
publisher	Elsevier
publishDate	2016
url	http://irep.iium.edu.my/55747/ http://irep.iium.edu.my/55747/ http://irep.iium.edu.my/55747/1/CES%202016.pdf
first_indexed	2023-09-18T21:18:43Z
last_indexed	2023-09-18T21:18:43Z
_version_	1777411737502351360

Fabrication, characterization and in vitro biocompatibility of electrospun hydroxyethyl cellulose/poly (vinyl) alcohol nanofibrous composite biomaterial for bone tissue engineering

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