Beyond classical meta-analysis: can inadequately reported studies be included?

Classical meta-analysis requires the same data from each clinical trial, thus data-reporting must be of a high-quality. Imputation methods are used to include studies that provide incomplete information on variability and the fixed and random effects of a drug. Regression models can be used to inclu...

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Main Authors:	Roberson, Chris, Nik Idris, Nik Ruzni, Boyle, Peter
Format:	Article
Language:	English
Published:	Elsevier Science Limited 2004
Subjects:	HA Statistics
Online Access:	http://irep.iium.edu.my/5556/ http://irep.iium.edu.my/5556/ http://irep.iium.edu.my/5556/ http://irep.iium.edu.my/5556/1/DDT_beyond_classical_MA.pdf

id	iium-5556
recordtype	eprints
spelling	iium-55562011-11-21T23:14:56Z http://irep.iium.edu.my/5556/ Beyond classical meta-analysis: can inadequately reported studies be included? Roberson, Chris Nik Idris, Nik Ruzni Boyle, Peter HA Statistics Classical meta-analysis requires the same data from each clinical trial, thus data-reporting must be of a high-quality. Imputation methods are used to include studies that provide incomplete information on variability and the fixed and random effects of a drug. Regression models can be used to include studies other than randomized placebo-controlled studies. In the example outlined here, the use of non-randomized single-arm studies and studies against comparator treatments has little influence on the estimation of the treatment effect in comparison with placebo, an effect that is based on the randomized placebo-controlled studies. The inclusion of other studies serves to increase the precision of the effect of the treatment compared with baseline. Although multiple imputation techniques enable a larger number of studies to be included, which will typically increase the precision of the estimated effect, a careful sensitivity analysis is also required Elsevier Science Limited 2004-11-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/5556/1/DDT_beyond_classical_MA.pdf Roberson, Chris and Nik Idris, Nik Ruzni and Boyle, Peter (2004) Beyond classical meta-analysis: can inadequately reported studies be included? Drug Discovery Today, 9 (21). pp. 924-931. ISSN 1359-6446 http://www.sciencedirect.com/science/article/pii/S135964460403274X doi:10.1016/S1359-6446(04)03274-X
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	HA Statistics
spellingShingle	HA Statistics Roberson, Chris Nik Idris, Nik Ruzni Boyle, Peter Beyond classical meta-analysis: can inadequately reported studies be included?
description	Classical meta-analysis requires the same data from each clinical trial, thus data-reporting must be of a high-quality. Imputation methods are used to include studies that provide incomplete information on variability and the fixed and random effects of a drug. Regression models can be used to include studies other than randomized placebo-controlled studies. In the example outlined here, the use of non-randomized single-arm studies and studies against comparator treatments has little influence on the estimation of the treatment effect in comparison with placebo, an effect that is based on the randomized placebo-controlled studies. The inclusion of other studies serves to increase the precision of the effect of the treatment compared with baseline. Although multiple imputation techniques enable a larger number of studies to be included, which will typically increase the precision of the estimated effect, a careful sensitivity analysis is also required
format	Article
author	Roberson, Chris Nik Idris, Nik Ruzni Boyle, Peter
author_facet	Roberson, Chris Nik Idris, Nik Ruzni Boyle, Peter
author_sort	Roberson, Chris
title	Beyond classical meta-analysis: can inadequately reported studies be included?
title_short	Beyond classical meta-analysis: can inadequately reported studies be included?
title_full	Beyond classical meta-analysis: can inadequately reported studies be included?
title_fullStr	Beyond classical meta-analysis: can inadequately reported studies be included?
title_full_unstemmed	Beyond classical meta-analysis: can inadequately reported studies be included?
title_sort	beyond classical meta-analysis: can inadequately reported studies be included?
publisher	Elsevier Science Limited
publishDate	2004
url	http://irep.iium.edu.my/5556/ http://irep.iium.edu.my/5556/ http://irep.iium.edu.my/5556/ http://irep.iium.edu.my/5556/1/DDT_beyond_classical_MA.pdf
first_indexed	2023-09-18T20:14:12Z
last_indexed	2023-09-18T20:14:12Z
_version_	1777407678487724032

Beyond classical meta-analysis: can inadequately reported studies be included?

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