Model of a critical size defect in the New Zealand White rabbit’s tibia
Introduction: Critical size defects (CSD) in the long bones of New Zealand White rabbit (Oryctolagus cuniculus) have been used for years as an experimental model for investigation of the effectiveness of a new bone substitute materials. There are varieties of protocols available in the literature...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Kulliyyah of Medicine, IIUM, Kuantan
2016
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/55462/ http://irep.iium.edu.my/55462/ http://irep.iium.edu.my/55462/1/Model%20of%20a%20critical%20size%20defect%20in%20the%20New%20Zealand%20White%20rabbit%E2%80%99s%20tibia.pdf |
| Summary: | Introduction:
Critical size defects (CSD) in the long bones of New Zealand White rabbit (Oryctolagus cuniculus) have been used for years as an experimental model for
investigation of the effectiveness of a new bone substitute materials. There are varieties of protocols available in the literature. This technical note attempts to present an
alternative surgical technique of a CSD in the New Zealand white rabbit tibia.
Methods:
Thirty-nine New Zealand White rabbits were used in this study. A CSD of approximately 4.5 mm (width) X 9.0 mm (length) was surgically drilled at the proximal tibial metaphysis, approximately 1 cm from the knee joint. The surrounding of soft tissue was repositioned and sutured layer by layer with bio absorbable surgical suture. Povidone soaked gauze and bandage were used as a dressing. There is no control group used in this study.
Results:
This alternative method created good CSD with less bleeding from the muscle observed.No mortality on other surgical complications were observed within 6 weeks, 12 weeks and
24 weeks following surgery. Conclusions: A simple and safe method for performing critical size defect was demonstrated and recommended as an approach for surgery on New
Zealand White rabbits. |
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