The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier

G protein-coupled receptor (GPCR) signalling is mediated through transactivation-independent signalling pathways or the transactivation of protein tyrosine kinase receptors and the recently reported activation of the serine/ threonine kinase receptors, most notably the transforming growth facto...

Full description

Bibliographic Details
Main Authors:	Kamato, Danielle, Rostam, Muhamad Ashraf, Bernard, Rebekah, Piva, Terence J., Mantri, Nitin, Guidone, Daniel, Zheng, Wenhua, Osman, Narin, Little, Peter J.
Format:	Article
Language:	English English
Published:	Springer International Publishing AG. Part of Springer Nature. 2015
Subjects:	QP Physiology
Online Access:	http://irep.iium.edu.my/55279/ http://irep.iium.edu.my/55279/ http://irep.iium.edu.my/55279/ http://irep.iium.edu.my/55279/1/4.%20Kamato-2015-The%20expansion%20of%20GPCR%20transactivat.pdf http://irep.iium.edu.my/55279/7/55279-The%20expansion%20of%20GPCR%20transactivation-dependent%20signalling_SCOPUS.pdf

id	iium-55279
recordtype	eprints
spelling	iium-552792017-03-23T01:03:13Z http://irep.iium.edu.my/55279/ The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier Kamato, Danielle Rostam, Muhamad Ashraf Bernard, Rebekah Piva, Terence J. Mantri, Nitin Guidone, Daniel Zheng, Wenhua Osman, Narin Little, Peter J. QP Physiology G protein-coupled receptor (GPCR) signalling is mediated through transactivation-independent signalling pathways or the transactivation of protein tyrosine kinase receptors and the recently reported activation of the serine/ threonine kinase receptors, most notably the transforming growth factor-b receptor family. Since the original observation of GPCR transactivation of protein tyrosine kinase receptors, there has been considerable work on the mechanism of transactivation and several pathways are prominent. These pathways include the ‘‘triple membrane bypass’’ pathway and the generation of reactive oxygen species. The recent recognition of GPCR transactivation of serine/threonine kinase receptors enormously broadens the GPCR signalling paradigm. It may be predicted that the transactivation of serine/threonine kinase receptors would have mechanistic similarities with transactivation of tyrosine kinase pathways; however, initial studies suggest that these two transactivation pathways are mechanistically distinct. Important questions are the relative importance of tyrosine and serine/threonine transactivation pathways, the contribution of transactivation to overall GPCR signalling, mechanisms of transactivation and the range of cell types in which this phenomenon occurs. The ultimate significance of transactivation-dependent signalling remains to be defined but it appears to be prominent and if so will represent a new cell signalling frontier. Springer International Publishing AG. Part of Springer Nature. 2015-02 Article PeerReviewed application/pdf en http://irep.iium.edu.my/55279/1/4.%20Kamato-2015-The%20expansion%20of%20GPCR%20transactivat.pdf application/pdf en http://irep.iium.edu.my/55279/7/55279-The%20expansion%20of%20GPCR%20transactivation-dependent%20signalling_SCOPUS.pdf Kamato, Danielle and Rostam, Muhamad Ashraf and Bernard, Rebekah and Piva, Terence J. and Mantri, Nitin and Guidone, Daniel and Zheng, Wenhua and Osman, Narin and Little, Peter J. (2015) The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier. Cellular and Molecular Life Sciences, 72 (4). pp. 799-808. ISSN 1420-682X E-ISSN 1420-9071 http://link.springer.com/article/10.1007/s00018-014-1775-0 10.1007/s00018-014-1775-0
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QP Physiology
spellingShingle	QP Physiology Kamato, Danielle Rostam, Muhamad Ashraf Bernard, Rebekah Piva, Terence J. Mantri, Nitin Guidone, Daniel Zheng, Wenhua Osman, Narin Little, Peter J. The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier
description	G protein-coupled receptor (GPCR) signalling is mediated through transactivation-independent signalling pathways or the transactivation of protein tyrosine kinase receptors and the recently reported activation of the serine/ threonine kinase receptors, most notably the transforming growth factor-b receptor family. Since the original observation of GPCR transactivation of protein tyrosine kinase receptors, there has been considerable work on the mechanism of transactivation and several pathways are prominent. These pathways include the ‘‘triple membrane bypass’’ pathway and the generation of reactive oxygen species. The recent recognition of GPCR transactivation of serine/threonine kinase receptors enormously broadens the GPCR signalling paradigm. It may be predicted that the transactivation of serine/threonine kinase receptors would have mechanistic similarities with transactivation of tyrosine kinase pathways; however, initial studies suggest that these two transactivation pathways are mechanistically distinct. Important questions are the relative importance of tyrosine and serine/threonine transactivation pathways, the contribution of transactivation to overall GPCR signalling, mechanisms of transactivation and the range of cell types in which this phenomenon occurs. The ultimate significance of transactivation-dependent signalling remains to be defined but it appears to be prominent and if so will represent a new cell signalling frontier.
format	Article
author	Kamato, Danielle Rostam, Muhamad Ashraf Bernard, Rebekah Piva, Terence J. Mantri, Nitin Guidone, Daniel Zheng, Wenhua Osman, Narin Little, Peter J.
author_facet	Kamato, Danielle Rostam, Muhamad Ashraf Bernard, Rebekah Piva, Terence J. Mantri, Nitin Guidone, Daniel Zheng, Wenhua Osman, Narin Little, Peter J.
author_sort	Kamato, Danielle
title	The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier
title_short	The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier
title_full	The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier
title_fullStr	The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier
title_full_unstemmed	The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier
title_sort	expansion of gpcr transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier
publisher	Springer International Publishing AG. Part of Springer Nature.
publishDate	2015
url	http://irep.iium.edu.my/55279/ http://irep.iium.edu.my/55279/ http://irep.iium.edu.my/55279/ http://irep.iium.edu.my/55279/1/4.%20Kamato-2015-The%20expansion%20of%20GPCR%20transactivat.pdf http://irep.iium.edu.my/55279/7/55279-The%20expansion%20of%20GPCR%20transactivation-dependent%20signalling_SCOPUS.pdf
first_indexed	2023-09-18T21:18:08Z
last_indexed	2023-09-18T21:18:08Z
_version_	1777411700947943424

The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier

Similar Items