The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier
G protein-coupled receptor (GPCR) signalling is mediated through transactivation-independent signalling pathways or the transactivation of protein tyrosine kinase receptors and the recently reported activation of the serine/ threonine kinase receptors, most notably the transforming growth facto...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Springer International Publishing AG. Part of Springer Nature.
2015
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/55279/ http://irep.iium.edu.my/55279/ http://irep.iium.edu.my/55279/ http://irep.iium.edu.my/55279/1/4.%20Kamato-2015-The%20expansion%20of%20GPCR%20transactivat.pdf http://irep.iium.edu.my/55279/7/55279-The%20expansion%20of%20GPCR%20transactivation-dependent%20signalling_SCOPUS.pdf |
| Summary: | G protein-coupled receptor (GPCR) signalling
is mediated through transactivation-independent signalling
pathways or the transactivation of protein tyrosine kinase
receptors and the recently reported activation of the serine/
threonine kinase receptors, most notably the transforming
growth factor-b receptor family. Since the original observation
of GPCR transactivation of protein tyrosine kinase
receptors, there has been considerable work on the mechanism
of transactivation and several pathways are
prominent. These pathways include the ‘‘triple membrane
bypass’’ pathway and the generation of reactive oxygen
species. The recent recognition of GPCR transactivation of
serine/threonine kinase receptors enormously broadens the
GPCR signalling paradigm. It may be predicted that the
transactivation of serine/threonine kinase receptors would
have mechanistic similarities with transactivation of tyrosine
kinase pathways; however, initial studies suggest that
these two transactivation pathways are mechanistically
distinct. Important questions are the relative importance of
tyrosine and serine/threonine transactivation pathways, the
contribution of transactivation to overall GPCR signalling,
mechanisms of transactivation and the range of cell types
in which this phenomenon occurs. The ultimate significance
of transactivation-dependent signalling remains to be
defined but it appears to be prominent and if so will represent
a new cell signalling frontier. |
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