Peptidyl-prolyl isomerases: Functionality and potential therapeutic targets in cardiovascular disease

Peptidyl-prolyl cis/trans isomerases (PPIases) are a conserved group of enzymes that catalyse the conversion between cis and trans conformations of proline imidic peptide bonds. These enzymes play critical roles in regulatory mechanisms of cellular function and pathophysiology of disease. There are...

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Main Authors:	Rostam, Muhamad Ashraf, Piva, Terence J., Rezaei, Hossein B., Kamato, Danielle, Little, Peter J., Zheng, Wenhua, Osman, Narin
Format:	Article
Language:	English English
Published:	Wiley Online Library 2015
Subjects:	QP Physiology
Online Access:	http://irep.iium.edu.my/55276/ http://irep.iium.edu.my/55276/ http://irep.iium.edu.my/55276/ http://irep.iium.edu.my/55276/1/3.%20Rostam-2015-Peptidyl-prolyl%20isomerases_%20Functi.pdf http://irep.iium.edu.my/55276/7/55267-Peptidyl-prolyl%20isomerases_SCOPUS.pdf

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spelling	iium-552762017-07-18T00:30:05Z http://irep.iium.edu.my/55276/ Peptidyl-prolyl isomerases: Functionality and potential therapeutic targets in cardiovascular disease Rostam, Muhamad Ashraf Piva, Terence J. Rezaei, Hossein B. Kamato, Danielle Little, Peter J. Zheng, Wenhua Osman, Narin QP Physiology Peptidyl-prolyl cis/trans isomerases (PPIases) are a conserved group of enzymes that catalyse the conversion between cis and trans conformations of proline imidic peptide bonds. These enzymes play critical roles in regulatory mechanisms of cellular function and pathophysiology of disease. There are three different classes of PPIases and increasing interest in the development of specific PPIase inhibitors. Cyclosporine A, FK506, rapamycin and juglone are known PPIase inhibitors. Herein, we review recent advances in elucidating the role and regulation of the PPIase family in vascular disease. We focus on peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1), an important member of the PPIase family that plays a role in cell cycle progression, gene expression, cell signalling and cell proliferation. In addition, Pin1 may be involved in atherosclerosis. The unique role of Pin1 as a molecular switch that impacts on multiple downstream pathways necessitates the evaluation of a highly specific Pin1 inhibitor to aid in potential therapeutic drug discovery. Wiley Online Library 2015-02 Article PeerReviewed application/pdf en http://irep.iium.edu.my/55276/1/3.%20Rostam-2015-Peptidyl-prolyl%20isomerases_%20Functi.pdf application/pdf en http://irep.iium.edu.my/55276/7/55267-Peptidyl-prolyl%20isomerases_SCOPUS.pdf Rostam, Muhamad Ashraf and Piva, Terence J. and Rezaei, Hossein B. and Kamato, Danielle and Little, Peter J. and Zheng, Wenhua and Osman, Narin (2015) Peptidyl-prolyl isomerases: Functionality and potential therapeutic targets in cardiovascular disease. Clinical and Experimental Pharmacology and Physiology, 42 (2). pp. 117-124. E-ISSN 1440-1681 http://onlinelibrary.wiley.com/doi/10.1111/1440-1681.12335/full 10.1111/1440-1681.12335
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QP Physiology
spellingShingle	QP Physiology Rostam, Muhamad Ashraf Piva, Terence J. Rezaei, Hossein B. Kamato, Danielle Little, Peter J. Zheng, Wenhua Osman, Narin Peptidyl-prolyl isomerases: Functionality and potential therapeutic targets in cardiovascular disease
description	Peptidyl-prolyl cis/trans isomerases (PPIases) are a conserved group of enzymes that catalyse the conversion between cis and trans conformations of proline imidic peptide bonds. These enzymes play critical roles in regulatory mechanisms of cellular function and pathophysiology of disease. There are three different classes of PPIases and increasing interest in the development of specific PPIase inhibitors. Cyclosporine A, FK506, rapamycin and juglone are known PPIase inhibitors. Herein, we review recent advances in elucidating the role and regulation of the PPIase family in vascular disease. We focus on peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1), an important member of the PPIase family that plays a role in cell cycle progression, gene expression, cell signalling and cell proliferation. In addition, Pin1 may be involved in atherosclerosis. The unique role of Pin1 as a molecular switch that impacts on multiple downstream pathways necessitates the evaluation of a highly specific Pin1 inhibitor to aid in potential therapeutic drug discovery.
format	Article
author	Rostam, Muhamad Ashraf Piva, Terence J. Rezaei, Hossein B. Kamato, Danielle Little, Peter J. Zheng, Wenhua Osman, Narin
author_facet	Rostam, Muhamad Ashraf Piva, Terence J. Rezaei, Hossein B. Kamato, Danielle Little, Peter J. Zheng, Wenhua Osman, Narin
author_sort	Rostam, Muhamad Ashraf
title	Peptidyl-prolyl isomerases: Functionality and potential therapeutic targets in cardiovascular disease
title_short	Peptidyl-prolyl isomerases: Functionality and potential therapeutic targets in cardiovascular disease
title_full	Peptidyl-prolyl isomerases: Functionality and potential therapeutic targets in cardiovascular disease
title_fullStr	Peptidyl-prolyl isomerases: Functionality and potential therapeutic targets in cardiovascular disease
title_full_unstemmed	Peptidyl-prolyl isomerases: Functionality and potential therapeutic targets in cardiovascular disease
title_sort	peptidyl-prolyl isomerases: functionality and potential therapeutic targets in cardiovascular disease
publisher	Wiley Online Library
publishDate	2015
url	http://irep.iium.edu.my/55276/ http://irep.iium.edu.my/55276/ http://irep.iium.edu.my/55276/ http://irep.iium.edu.my/55276/1/3.%20Rostam-2015-Peptidyl-prolyl%20isomerases_%20Functi.pdf http://irep.iium.edu.my/55276/7/55267-Peptidyl-prolyl%20isomerases_SCOPUS.pdf
first_indexed	2023-09-18T21:18:08Z
last_indexed	2023-09-18T21:18:08Z
_version_	1777411700649099264

Peptidyl-prolyl isomerases: Functionality and potential therapeutic targets in cardiovascular disease

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