Investigation of anticancer peptides from zophobas moria fabricus

Cancer is an extremely complicated disease and still presents enormous challenges, in the medical world. Drug-based chemotherapy treatment are usually applied especially to combat cancer that cannot be treated by any other cancer treating method. Up-to-date there are so many drugs been researched a...

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Main Authors:	Chowdhury, Silvia, Yusof, Faridah, Faruck, Mohammad Omer, Sulaiman, Nadzril
Format:	Conference or Workshop Item
Language:	English
Published:	2015
Subjects:	T Technology (General) TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/55092/ http://irep.iium.edu.my/55092/ http://irep.iium.edu.my/55092/1/55092_INVESTIGATION%20OF%20ANTICANCER.pdf

id	iium-55092
recordtype	eprints
spelling	iium-550922017-03-30T02:30:19Z http://irep.iium.edu.my/55092/ Investigation of anticancer peptides from zophobas moria fabricus Chowdhury, Silvia Yusof, Faridah Faruck, Mohammad Omer Sulaiman, Nadzril T Technology (General) TP248.13 Biotechnology Cancer is an extremely complicated disease and still presents enormous challenges, in the medical world. Drug-based chemotherapy treatment are usually applied especially to combat cancer that cannot be treated by any other cancer treating method. Up-to-date there are so many drugs been researched and discovered and some of them are at the different phases of trials before commercialization. Anticancer agents based on natural resources are preferred compared to chemical based because the later can also be harmful towards healthy cells, thus elevating the side effects of chemotherapy. In this study, anticancer peptides has been recovered from non-immunized final instar larvae of Zophobas morio Fabricus using acidified (triflouroacetic acid) solvent (ethanol and isopropanol). Results showed that the two different extracts inhibits growth of MCF-7 breast cancer cell line at varying degrees. The results of cytotoxicity investigation and fluorescence microscopic observations conclude that the extracts could significantly inhibit MCF-7 cell viability and disrupt their cell morphology. Statistical analysis showed ethanolic and isopropanolic extract have IC50 of 1.7 mg/ml and 0.7 mg/ml respectively. This work may present the first initiative towards recovering anticancer peptides from natural, low cost, easily found insect larvae, whereby it can be potentially developed as peptide-based drug to be used in chemotherapy. Future work includes purifying, identification and characterization of peptides. 2015-11-19 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/55092/1/55092_INVESTIGATION%20OF%20ANTICANCER.pdf Chowdhury, Silvia and Yusof, Faridah and Faruck, Mohammad Omer and Sulaiman, Nadzril (2015) Investigation of anticancer peptides from zophobas moria fabricus. In: Asian Congress on Biotechnology 2015 (ACB 2015), 15th-19th Nov 2015, Istana Hotel, Kuala Lumpur. (Unpublished) http://www.acb2015.my
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	T Technology (General) TP248.13 Biotechnology
spellingShingle	T Technology (General) TP248.13 Biotechnology Chowdhury, Silvia Yusof, Faridah Faruck, Mohammad Omer Sulaiman, Nadzril Investigation of anticancer peptides from zophobas moria fabricus
description	Cancer is an extremely complicated disease and still presents enormous challenges, in the medical world. Drug-based chemotherapy treatment are usually applied especially to combat cancer that cannot be treated by any other cancer treating method. Up-to-date there are so many drugs been researched and discovered and some of them are at the different phases of trials before commercialization. Anticancer agents based on natural resources are preferred compared to chemical based because the later can also be harmful towards healthy cells, thus elevating the side effects of chemotherapy. In this study, anticancer peptides has been recovered from non-immunized final instar larvae of Zophobas morio Fabricus using acidified (triflouroacetic acid) solvent (ethanol and isopropanol). Results showed that the two different extracts inhibits growth of MCF-7 breast cancer cell line at varying degrees. The results of cytotoxicity investigation and fluorescence microscopic observations conclude that the extracts could significantly inhibit MCF-7 cell viability and disrupt their cell morphology. Statistical analysis showed ethanolic and isopropanolic extract have IC50 of 1.7 mg/ml and 0.7 mg/ml respectively. This work may present the first initiative towards recovering anticancer peptides from natural, low cost, easily found insect larvae, whereby it can be potentially developed as peptide-based drug to be used in chemotherapy. Future work includes purifying, identification and characterization of peptides.
format	Conference or Workshop Item
author	Chowdhury, Silvia Yusof, Faridah Faruck, Mohammad Omer Sulaiman, Nadzril
author_facet	Chowdhury, Silvia Yusof, Faridah Faruck, Mohammad Omer Sulaiman, Nadzril
author_sort	Chowdhury, Silvia
title	Investigation of anticancer peptides from zophobas moria fabricus
title_short	Investigation of anticancer peptides from zophobas moria fabricus
title_full	Investigation of anticancer peptides from zophobas moria fabricus
title_fullStr	Investigation of anticancer peptides from zophobas moria fabricus
title_full_unstemmed	Investigation of anticancer peptides from zophobas moria fabricus
title_sort	investigation of anticancer peptides from zophobas moria fabricus
publishDate	2015
url	http://irep.iium.edu.my/55092/ http://irep.iium.edu.my/55092/ http://irep.iium.edu.my/55092/1/55092_INVESTIGATION%20OF%20ANTICANCER.pdf
first_indexed	2023-09-18T21:17:54Z
last_indexed	2023-09-18T21:17:54Z
_version_	1777411685447892992

Investigation of anticancer peptides from zophobas moria fabricus

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