Early response in antibacterial activity of orthopaedic metal implant coated with silver composite for future osteomyelitis treatment: preliminary results

Objectives/Research Problem: The prevalence of chronic osteomyelitis remains high. The management of this disease poses a major challenge in orthopaedic. It is difficult to achieve an optimum or a definitive cure and to prevent serious complications. Orthopaedic implant infection is chronic and biof...

Full description

Bibliographic Details
Main Authors:	Mohd Jan, Nurul Hafiza, Zulkifly, Ahmad Hafiz, Ibrahim, Mohd Zulfadzli, Sha'ban, Munirah
Format:	Conference or Workshop Item
Language:	English
Published:	Kulliyyah of Allied Health Sciences, IIUM 2016
Subjects:	TA164 Bioengineering
Online Access:	http://irep.iium.edu.my/55023/ http://irep.iium.edu.my/55023/1/Nurul%20KRW2016%20Abstract.pdf

id	iium-55023
recordtype	eprints
spelling	iium-550232017-02-11T06:24:41Z http://irep.iium.edu.my/55023/ Early response in antibacterial activity of orthopaedic metal implant coated with silver composite for future osteomyelitis treatment: preliminary results Mohd Jan, Nurul Hafiza Zulkifly, Ahmad Hafiz Ibrahim, Mohd Zulfadzli Sha'ban, Munirah TA164 Bioengineering Objectives/Research Problem: The prevalence of chronic osteomyelitis remains high. The management of this disease poses a major challenge in orthopaedic. It is difficult to achieve an optimum or a definitive cure and to prevent serious complications. Orthopaedic implant infection is chronic and biofilm based. Current treatments for bone infection i.e. osteomyelitis include antimicrobial therapy or using antibiotics, debridement, and follow-up care involving stabilization of the bone and management of any remaining dead spaces post debridement. In order to achieve optimum therapeutic effect, high parenteral dose of antibiotic is needed to penetrate and kill the biofilm bacteria. However, high antibiotics dosage and prolonged course of treatment can lead to systemic toxicity. Hence, to overcome this, alternative treatment strategy using orthopaedic metallic implant coated with 3% silver composite as antibacterial agent have been introduced for osteomyelitis treatment. The 3% silver composite exhibits good bactericidal properties. It inhibits biofilm formation particularly, at the adhesion stage of the relevant bacteria. Hence, the aim of this study is to investigate the potential effect of silver coated orthopaedic metal implant against biofilm-producing Staphylococcus aureus through in vitro experimental setting. Materials and Method: The antibacterial property of orthopaedic metal implants was investigated using Staphylococcus aureus ATCC 25923. The implants were cut with an average size ranging from 3.0mm to 5.0mm of length. The antibacterial effect was evaluated based on the diameter of inhibition zone using disk diffusion test. Results and Discussion: The disk diffusion test showed that the inhibition zone with diameter is 20mm after one week of incubation which indicating the susceptible of concentrations against Staphylococcus aureus. The outcome of this study revealed positive response of the silver as antibacterial agent. The experiment is still ongoing. Conclusion: This result suggested that orthopaedic metal implant coated with silver composite has the intended antibacterial properties and may provide protection against medical device-related infection. Kulliyyah of Allied Health Sciences, IIUM 2016-11-21 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/55023/1/Nurul%20KRW2016%20Abstract.pdf Mohd Jan, Nurul Hafiza and Zulkifly, Ahmad Hafiz and Ibrahim, Mohd Zulfadzli and Sha'ban, Munirah (2016) Early response in antibacterial activity of orthopaedic metal implant coated with silver composite for future osteomyelitis treatment: preliminary results. In: KAHS Research Week (KRW) 2016 in conjunction with 1st Allied Health Scientific Colloquium (AHSC) 2016, 21 - 25 November 2016, Kuantan, Pahang.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	TA164 Bioengineering
spellingShingle	TA164 Bioengineering Mohd Jan, Nurul Hafiza Zulkifly, Ahmad Hafiz Ibrahim, Mohd Zulfadzli Sha'ban, Munirah Early response in antibacterial activity of orthopaedic metal implant coated with silver composite for future osteomyelitis treatment: preliminary results
description	Objectives/Research Problem: The prevalence of chronic osteomyelitis remains high. The management of this disease poses a major challenge in orthopaedic. It is difficult to achieve an optimum or a definitive cure and to prevent serious complications. Orthopaedic implant infection is chronic and biofilm based. Current treatments for bone infection i.e. osteomyelitis include antimicrobial therapy or using antibiotics, debridement, and follow-up care involving stabilization of the bone and management of any remaining dead spaces post debridement. In order to achieve optimum therapeutic effect, high parenteral dose of antibiotic is needed to penetrate and kill the biofilm bacteria. However, high antibiotics dosage and prolonged course of treatment can lead to systemic toxicity. Hence, to overcome this, alternative treatment strategy using orthopaedic metallic implant coated with 3% silver composite as antibacterial agent have been introduced for osteomyelitis treatment. The 3% silver composite exhibits good bactericidal properties. It inhibits biofilm formation particularly, at the adhesion stage of the relevant bacteria. Hence, the aim of this study is to investigate the potential effect of silver coated orthopaedic metal implant against biofilm-producing Staphylococcus aureus through in vitro experimental setting. Materials and Method: The antibacterial property of orthopaedic metal implants was investigated using Staphylococcus aureus ATCC 25923. The implants were cut with an average size ranging from 3.0mm to 5.0mm of length. The antibacterial effect was evaluated based on the diameter of inhibition zone using disk diffusion test. Results and Discussion: The disk diffusion test showed that the inhibition zone with diameter is 20mm after one week of incubation which indicating the susceptible of concentrations against Staphylococcus aureus. The outcome of this study revealed positive response of the silver as antibacterial agent. The experiment is still ongoing. Conclusion: This result suggested that orthopaedic metal implant coated with silver composite has the intended antibacterial properties and may provide protection against medical device-related infection.
format	Conference or Workshop Item
author	Mohd Jan, Nurul Hafiza Zulkifly, Ahmad Hafiz Ibrahim, Mohd Zulfadzli Sha'ban, Munirah
author_facet	Mohd Jan, Nurul Hafiza Zulkifly, Ahmad Hafiz Ibrahim, Mohd Zulfadzli Sha'ban, Munirah
author_sort	Mohd Jan, Nurul Hafiza
title	Early response in antibacterial activity of orthopaedic metal implant coated with silver composite for future osteomyelitis treatment: preliminary results
title_short	Early response in antibacterial activity of orthopaedic metal implant coated with silver composite for future osteomyelitis treatment: preliminary results
title_full	Early response in antibacterial activity of orthopaedic metal implant coated with silver composite for future osteomyelitis treatment: preliminary results
title_fullStr	Early response in antibacterial activity of orthopaedic metal implant coated with silver composite for future osteomyelitis treatment: preliminary results
title_full_unstemmed	Early response in antibacterial activity of orthopaedic metal implant coated with silver composite for future osteomyelitis treatment: preliminary results
title_sort	early response in antibacterial activity of orthopaedic metal implant coated with silver composite for future osteomyelitis treatment: preliminary results
publisher	Kulliyyah of Allied Health Sciences, IIUM
publishDate	2016
url	http://irep.iium.edu.my/55023/ http://irep.iium.edu.my/55023/1/Nurul%20KRW2016%20Abstract.pdf
first_indexed	2023-09-18T21:17:47Z
last_indexed	2023-09-18T21:17:47Z
_version_	1777411678405656576

Early response in antibacterial activity of orthopaedic metal implant coated with silver composite for future osteomyelitis treatment: preliminary results

Similar Items