Micronized carvedilol SR matrix tablet for improved dissolution

Sustained release (SR) matrix formulation can overcome the disadvantages of frequent dosing of conventional tablet. Poor soluble drugs (BCS class II) suffer from low bioavailability due to low dissolution rate. Micronization is one of the easiest approaches to enhance solubility of drugs. Formulatio...

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Main Author:	Chatterjee, Bappaditya
Format:	Book
Language:	English
Published:	Lambert Academic Publishing 2016
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/54953/ http://irep.iium.edu.my/54953/1/54953_Micronized%20carvedilol%20SR%20matrix%20tablet%20for%20improved%20dissolution.pdf

id	iium-54953
recordtype	eprints
spelling	iium-549532017-02-10T01:52:49Z http://irep.iium.edu.my/54953/ Micronized carvedilol SR matrix tablet for improved dissolution Chatterjee, Bappaditya RS Pharmacy and materia medica Sustained release (SR) matrix formulation can overcome the disadvantages of frequent dosing of conventional tablet. Poor soluble drugs (BCS class II) suffer from low bioavailability due to low dissolution rate. Micronization is one of the easiest approaches to enhance solubility of drugs. Formulation of a SR matrix tablet with micronized drug particle will help to enhance dissolution as well as prolong the duration of drug release. In the research work entitled “micronized carvedilol SR matrix tablet for improved dissolution”, Carvedilol, a BCS class II β blocker drug is formulated as a SR matrix tablet with micronized drug particle. Direct compression method was applied to prepare tablet using PEO 301 as a release retardant polymer. The formulation was optimized by a 3 level factorial design considering amount of PEO 301 and hardness of tablet as dependent variables. In-vitro release study showed near about 100% of drug release in 12 hrs. for lowest particle size drug whereas for non-micronized drug it was less than 80%. The developed tablet showed desired stability for 3 months in accelerated conditions. The developed micronized carvedilol SR matrix tablet can be proposed for in-vivo assessment after relevant toxicity studies. Lambert Academic Publishing Chatterjee, Bappaditya 2016-12 Book PeerReviewed application/pdf en http://irep.iium.edu.my/54953/1/54953_Micronized%20carvedilol%20SR%20matrix%20tablet%20for%20improved%20dissolution.pdf Chatterjee, Bappaditya (2016) Micronized carvedilol SR matrix tablet for improved dissolution. Lambert Academic Publishing, Germany. ISBN 978-3-330-01078-9
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Chatterjee, Bappaditya Micronized carvedilol SR matrix tablet for improved dissolution
description	Sustained release (SR) matrix formulation can overcome the disadvantages of frequent dosing of conventional tablet. Poor soluble drugs (BCS class II) suffer from low bioavailability due to low dissolution rate. Micronization is one of the easiest approaches to enhance solubility of drugs. Formulation of a SR matrix tablet with micronized drug particle will help to enhance dissolution as well as prolong the duration of drug release. In the research work entitled “micronized carvedilol SR matrix tablet for improved dissolution”, Carvedilol, a BCS class II β blocker drug is formulated as a SR matrix tablet with micronized drug particle. Direct compression method was applied to prepare tablet using PEO 301 as a release retardant polymer. The formulation was optimized by a 3 level factorial design considering amount of PEO 301 and hardness of tablet as dependent variables. In-vitro release study showed near about 100% of drug release in 12 hrs. for lowest particle size drug whereas for non-micronized drug it was less than 80%. The developed tablet showed desired stability for 3 months in accelerated conditions. The developed micronized carvedilol SR matrix tablet can be proposed for in-vivo assessment after relevant toxicity studies.
author2	Chatterjee, Bappaditya
author_facet	Chatterjee, Bappaditya Chatterjee, Bappaditya
format	Book
author	Chatterjee, Bappaditya
author_sort	Chatterjee, Bappaditya
title	Micronized carvedilol SR matrix tablet for improved dissolution
title_short	Micronized carvedilol SR matrix tablet for improved dissolution
title_full	Micronized carvedilol SR matrix tablet for improved dissolution
title_fullStr	Micronized carvedilol SR matrix tablet for improved dissolution
title_full_unstemmed	Micronized carvedilol SR matrix tablet for improved dissolution
title_sort	micronized carvedilol sr matrix tablet for improved dissolution
publisher	Lambert Academic Publishing
publishDate	2016
url	http://irep.iium.edu.my/54953/ http://irep.iium.edu.my/54953/1/54953_Micronized%20carvedilol%20SR%20matrix%20tablet%20for%20improved%20dissolution.pdf
first_indexed	2023-09-18T21:17:42Z
last_indexed	2023-09-18T21:17:42Z
_version_	1777411673450086400

Micronized carvedilol SR matrix tablet for improved dissolution

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