Evaluation of in vitro antidiabetic and antioxidant characterizations of Elettaria cardamomum (L.) Maton (Zingiberaceae), Piper cubeba L. f. (Piperaceae), and Plumeria rubra L. (Apocynaceae)

Inhibition of intestinal α-amylase and α-glucosidase is an important strategy to regulate diabetes mellitus (DM). Antioxidants from plants are widely regarded in the prevention of diabetes. Fruits of Elettaria cardamomum (L.) Maton (Zingiberaceae) and Piper cubeba L. f. (Piperaceae) and flowers of P...

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Main Authors:	Sh. Ahmed, Afnan, Ahmed, Qamar Uddin, Saxena, Anil Kumar, Jamal, Parveen
Format:	Article
Language:	English English English
Published:	Pakistan Journal of Pharmaceutical Sciences 2017
Subjects:	Q Science (General) QD Chemistry
Online Access:	http://irep.iium.edu.my/54794/ http://irep.iium.edu.my/54794/ http://irep.iium.edu.my/54794/1/Paper-17_Pak.%20J.%20Pharm.%20Sci.%2C%20Vol.30%2C%20No.1%2C%20January%202017%2C%20pp.113-126.pdf http://irep.iium.edu.my/54794/7/54794-Evaluation%20of%20in%20vitro%20antidiabetic%20and%20antioxidant%20characterizations_SCOPUS.pdf http://irep.iium.edu.my/54794/13/54794_Evaluation%20of%20in%20vitro_WOS.pdf

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spelling	iium-547942017-06-01T03:43:51Z http://irep.iium.edu.my/54794/ Evaluation of in vitro antidiabetic and antioxidant characterizations of Elettaria cardamomum (L.) Maton (Zingiberaceae), Piper cubeba L. f. (Piperaceae), and Plumeria rubra L. (Apocynaceae) Sh. Ahmed, Afnan Ahmed, Qamar Uddin Saxena, Anil Kumar Jamal, Parveen Q Science (General) QD Chemistry Inhibition of intestinal α-amylase and α-glucosidase is an important strategy to regulate diabetes mellitus (DM). Antioxidants from plants are widely regarded in the prevention of diabetes. Fruits of Elettaria cardamomum (L.) Maton (Zingiberaceae) and Piper cubeba L. f. (Piperaceae) and flowers of Plumeria rubra L. (Apocynaceae) are traditionally used to cure DM in different countries. However, the role of these plants has been grossly under reported and is yet to receive proper scientific evaluation with respect to understand their traditional role in the management of diabetes especially as digestive enzymes inhibitors. Hence, methanol and aqueous extracts of the aforementioned plants were evaluated for their in vitro α-glucosidase and α-amylase inhibition at 1 mg/mL and quantification of their antioxidant properties (DPPH, FRAP tests, total phenolic and total flavonoids contents). In vitro optimization studies for the extracts were also performed to enhance in vitro biological activities. The % inhibition of α-glucosidase by the aqueous extracts of the fruits of E. cardamomum, P. cubeba and flowers of P. rubra were 10.41 (0.03), 95.19 (0.01), and -2.92 (0.03), while the methanol extracts exhibited % inhibition 13.73 (0.02), 92.77 (0.01), and -0.98 (0.01), respectively. The % inhibition of α-amylase by the aqueous extracts were 82.99 (0.01), 64.35 (0.01), and 20.28 (0.02), while the methanol extracts displayed % inhibition 39.93 (0.01), 31.06 (0.02), and 39.40 (0.01), respectively. Aqueous extracts displayed good in vitro antidiabetic and antioxidant activities. Moreover, in vitro optimization experiments helped to increase the α-glucosidase inhibitory activity of E. cardamomum. Our findings further justify the traditional claims of these plants as folk medicines to manage diabetes, however, through digestive enzymes inhibition effect. Pakistan Journal of Pharmaceutical Sciences 2017-01-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/54794/1/Paper-17_Pak.%20J.%20Pharm.%20Sci.%2C%20Vol.30%2C%20No.1%2C%20January%202017%2C%20pp.113-126.pdf application/pdf en http://irep.iium.edu.my/54794/7/54794-Evaluation%20of%20in%20vitro%20antidiabetic%20and%20antioxidant%20characterizations_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/54794/13/54794_Evaluation%20of%20in%20vitro_WOS.pdf Sh. Ahmed, Afnan and Ahmed, Qamar Uddin and Saxena, Anil Kumar and Jamal, Parveen (2017) Evaluation of in vitro antidiabetic and antioxidant characterizations of Elettaria cardamomum (L.) Maton (Zingiberaceae), Piper cubeba L. f. (Piperaceae), and Plumeria rubra L. (Apocynaceae). Pakistan Journal of Pharmaceutical Sciences, 30 (1). pp. 113-126. ISSN 1011-601X http://www.pjps.pk/wp-content/uploads/pdfs/30/1/Paper-17.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	Q Science (General) QD Chemistry
spellingShingle	Q Science (General) QD Chemistry Sh. Ahmed, Afnan Ahmed, Qamar Uddin Saxena, Anil Kumar Jamal, Parveen Evaluation of in vitro antidiabetic and antioxidant characterizations of Elettaria cardamomum (L.) Maton (Zingiberaceae), Piper cubeba L. f. (Piperaceae), and Plumeria rubra L. (Apocynaceae)
description	Inhibition of intestinal α-amylase and α-glucosidase is an important strategy to regulate diabetes mellitus (DM). Antioxidants from plants are widely regarded in the prevention of diabetes. Fruits of Elettaria cardamomum (L.) Maton (Zingiberaceae) and Piper cubeba L. f. (Piperaceae) and flowers of Plumeria rubra L. (Apocynaceae) are traditionally used to cure DM in different countries. However, the role of these plants has been grossly under reported and is yet to receive proper scientific evaluation with respect to understand their traditional role in the management of diabetes especially as digestive enzymes inhibitors. Hence, methanol and aqueous extracts of the aforementioned plants were evaluated for their in vitro α-glucosidase and α-amylase inhibition at 1 mg/mL and quantification of their antioxidant properties (DPPH, FRAP tests, total phenolic and total flavonoids contents). In vitro optimization studies for the extracts were also performed to enhance in vitro biological activities. The % inhibition of α-glucosidase by the aqueous extracts of the fruits of E. cardamomum, P. cubeba and flowers of P. rubra were 10.41 (0.03), 95.19 (0.01), and -2.92 (0.03), while the methanol extracts exhibited % inhibition 13.73 (0.02), 92.77 (0.01), and -0.98 (0.01), respectively. The % inhibition of α-amylase by the aqueous extracts were 82.99 (0.01), 64.35 (0.01), and 20.28 (0.02), while the methanol extracts displayed % inhibition 39.93 (0.01), 31.06 (0.02), and 39.40 (0.01), respectively. Aqueous extracts displayed good in vitro antidiabetic and antioxidant activities. Moreover, in vitro optimization experiments helped to increase the α-glucosidase inhibitory activity of E. cardamomum. Our findings further justify the traditional claims of these plants as folk medicines to manage diabetes, however, through digestive enzymes inhibition effect.
format	Article
author	Sh. Ahmed, Afnan Ahmed, Qamar Uddin Saxena, Anil Kumar Jamal, Parveen
author_facet	Sh. Ahmed, Afnan Ahmed, Qamar Uddin Saxena, Anil Kumar Jamal, Parveen
author_sort	Sh. Ahmed, Afnan
title	Evaluation of in vitro antidiabetic and antioxidant characterizations of Elettaria cardamomum (L.) Maton (Zingiberaceae), Piper cubeba L. f. (Piperaceae), and Plumeria rubra L. (Apocynaceae)
title_short	Evaluation of in vitro antidiabetic and antioxidant characterizations of Elettaria cardamomum (L.) Maton (Zingiberaceae), Piper cubeba L. f. (Piperaceae), and Plumeria rubra L. (Apocynaceae)
title_full	Evaluation of in vitro antidiabetic and antioxidant characterizations of Elettaria cardamomum (L.) Maton (Zingiberaceae), Piper cubeba L. f. (Piperaceae), and Plumeria rubra L. (Apocynaceae)
title_fullStr	Evaluation of in vitro antidiabetic and antioxidant characterizations of Elettaria cardamomum (L.) Maton (Zingiberaceae), Piper cubeba L. f. (Piperaceae), and Plumeria rubra L. (Apocynaceae)
title_full_unstemmed	Evaluation of in vitro antidiabetic and antioxidant characterizations of Elettaria cardamomum (L.) Maton (Zingiberaceae), Piper cubeba L. f. (Piperaceae), and Plumeria rubra L. (Apocynaceae)
title_sort	evaluation of in vitro antidiabetic and antioxidant characterizations of elettaria cardamomum (l.) maton (zingiberaceae), piper cubeba l. f. (piperaceae), and plumeria rubra l. (apocynaceae)
publisher	Pakistan Journal of Pharmaceutical Sciences
publishDate	2017
url	http://irep.iium.edu.my/54794/ http://irep.iium.edu.my/54794/ http://irep.iium.edu.my/54794/1/Paper-17_Pak.%20J.%20Pharm.%20Sci.%2C%20Vol.30%2C%20No.1%2C%20January%202017%2C%20pp.113-126.pdf http://irep.iium.edu.my/54794/7/54794-Evaluation%20of%20in%20vitro%20antidiabetic%20and%20antioxidant%20characterizations_SCOPUS.pdf http://irep.iium.edu.my/54794/13/54794_Evaluation%20of%20in%20vitro_WOS.pdf
first_indexed	2023-09-18T21:17:29Z
last_indexed	2023-09-18T21:17:29Z
_version_	1777411659620417536

Evaluation of in vitro antidiabetic and antioxidant characterizations of Elettaria cardamomum (L.) Maton (Zingiberaceae), Piper cubeba L. f. (Piperaceae), and Plumeria rubra L. (Apocynaceae)

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