Gene therapy in oral cancer: a promising prospect

Oral squamous cell carcinoma (SCC) is the most frequently occurring malignant tumor of the oral cavity with poor prognosis resulting in major morbidity and mortality. The incidence of oral SCC is increasing in developing countries including Indonesia. Modifications of conventional cancer therapies,...

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Main Author:	Arief Ichwan, Solachuddin Jauhari
Format:	Conference or Workshop Item
Language:	English English
Published:	2016
Subjects:	RC0254 Neoplasms. Tumors. Oncology (including Cancer) RK Dentistry RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/54791/ http://irep.iium.edu.my/54791/1/Gene%20Therapy%20on%20Oral%20Cancer.pdf http://irep.iium.edu.my/54791/2/KonferansKas%C4%B1m2016_2%20%281%29.pdf

id	iium-54791
recordtype	eprints
spelling	iium-547912017-02-20T03:05:00Z http://irep.iium.edu.my/54791/ Gene therapy in oral cancer: a promising prospect Arief Ichwan, Solachuddin Jauhari RC0254 Neoplasms. Tumors. Oncology (including Cancer) RK Dentistry RS Pharmacy and materia medica Oral squamous cell carcinoma (SCC) is the most frequently occurring malignant tumor of the oral cavity with poor prognosis resulting in major morbidity and mortality. The incidence of oral SCC is increasing in developing countries including Indonesia. Modifications of conventional cancer therapies, including surgery, radiotherapy, and chemotherapy, have not improved the survival rates of patients oral cancer. Even, tumors recur in approximately one third of patients which mainly lead to severe morbidity. The recurring cancer is often considered incurable since majority of cases; palliative surgery is disfiguring and more complicated, whereas some tumors have become resistant to either chemotherapy or further radiotherapy. For this reason, gene therapy has been developed and considered as a new approach that may effective in combating cancers. Gene therapy can be defined as the treatment of disease by replacing, altering, or supplementing a gene that is absent or abnormal and whose absence or abnormality is responsible for a disease. Like any other type of cancers, oral cancer cells harbor genetic mutations which resulting in failures to restrict or control the cell growth. Although still in its early stages, gene therapy holds great promise for the treatment of oral cancer. This review will attempt to discuss the principles and methods of gene therapy especially those utilized for treatment of oral cancer. The ongoing clinical trials that are being conducted also will be summarized. 2016-11-30 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/54791/1/Gene%20Therapy%20on%20Oral%20Cancer.pdf application/pdf en http://irep.iium.edu.my/54791/2/KonferansKas%C4%B1m2016_2%20%281%29.pdf Arief Ichwan, Solachuddin Jauhari (2016) Gene therapy in oral cancer: a promising prospect. In: Special Talk, 30 Nov. 2016, Institute of Medical and Health Science Sakarya University. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RC0254 Neoplasms. Tumors. Oncology (including Cancer) RK Dentistry RS Pharmacy and materia medica
spellingShingle	RC0254 Neoplasms. Tumors. Oncology (including Cancer) RK Dentistry RS Pharmacy and materia medica Arief Ichwan, Solachuddin Jauhari Gene therapy in oral cancer: a promising prospect
description	Oral squamous cell carcinoma (SCC) is the most frequently occurring malignant tumor of the oral cavity with poor prognosis resulting in major morbidity and mortality. The incidence of oral SCC is increasing in developing countries including Indonesia. Modifications of conventional cancer therapies, including surgery, radiotherapy, and chemotherapy, have not improved the survival rates of patients oral cancer. Even, tumors recur in approximately one third of patients which mainly lead to severe morbidity. The recurring cancer is often considered incurable since majority of cases; palliative surgery is disfiguring and more complicated, whereas some tumors have become resistant to either chemotherapy or further radiotherapy. For this reason, gene therapy has been developed and considered as a new approach that may effective in combating cancers. Gene therapy can be defined as the treatment of disease by replacing, altering, or supplementing a gene that is absent or abnormal and whose absence or abnormality is responsible for a disease. Like any other type of cancers, oral cancer cells harbor genetic mutations which resulting in failures to restrict or control the cell growth. Although still in its early stages, gene therapy holds great promise for the treatment of oral cancer. This review will attempt to discuss the principles and methods of gene therapy especially those utilized for treatment of oral cancer. The ongoing clinical trials that are being conducted also will be summarized.
format	Conference or Workshop Item
author	Arief Ichwan, Solachuddin Jauhari
author_facet	Arief Ichwan, Solachuddin Jauhari
author_sort	Arief Ichwan, Solachuddin Jauhari
title	Gene therapy in oral cancer: a promising prospect
title_short	Gene therapy in oral cancer: a promising prospect
title_full	Gene therapy in oral cancer: a promising prospect
title_fullStr	Gene therapy in oral cancer: a promising prospect
title_full_unstemmed	Gene therapy in oral cancer: a promising prospect
title_sort	gene therapy in oral cancer: a promising prospect
publishDate	2016
url	http://irep.iium.edu.my/54791/ http://irep.iium.edu.my/54791/1/Gene%20Therapy%20on%20Oral%20Cancer.pdf http://irep.iium.edu.my/54791/2/KonferansKas%C4%B1m2016_2%20%281%29.pdf
first_indexed	2023-09-18T21:17:29Z
last_indexed	2023-09-18T21:17:29Z
_version_	1777411659324719104

Gene therapy in oral cancer: a promising prospect

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