Vasorelaxation effect of Syzygium polyanthum (wight) walp. Leaves extract on isolated thoracic aorta rings of normal and hypertensive rats

Introduction: Syzygium polyanthum (Wight) Walp. leaves are traditionally consumed by the Malays as an alternative treatment for hypertension. Until now, effect of S. polyanthum leaves extract on blood vessel is not yet disclosed. Methods: This study investigated the effect of S. polyanthum leaves aq...

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Main Authors:	Ismail, Azlini, Wan Ahmad, Wan Amir Nizam
Format:	Conference or Workshop Item
Language:	English English English English
Published:	IIUM 2016
Subjects:	RM Therapeutics. Pharmacology RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/54723/ http://irep.iium.edu.my/54723/ http://irep.iium.edu.my/54723/1/poster%20presentation%20mrs.pdf http://irep.iium.edu.my/54723/2/front%20page%20abstract%20book.pdf http://irep.iium.edu.my/54723/3/List%20of%20Poster%20Presentation.pdf http://irep.iium.edu.my/54723/5/MRS2016-ABSTRACT-BOOK-102.pdf

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spelling	iium-547232017-02-12T14:45:47Z http://irep.iium.edu.my/54723/ Vasorelaxation effect of Syzygium polyanthum (wight) walp. Leaves extract on isolated thoracic aorta rings of normal and hypertensive rats Ismail, Azlini Wan Ahmad, Wan Amir Nizam RM Therapeutics. Pharmacology RS Pharmacy and materia medica Introduction: Syzygium polyanthum (Wight) Walp. leaves are traditionally consumed by the Malays as an alternative treatment for hypertension. Until now, effect of S. polyanthum leaves extract on blood vessel is not yet disclosed. Methods: This study investigated the effect of S. polyanthum leaves aqueous extract (AESP) (0.01, 0.1, 1 & 10 mg/ml) on isolated thoracic aorta rings of normotensive Wistar-Kyoto rats (WKY) and Spontaneously Hypertensive rats (SHR). Both rings were pre-contracted using phenylephrine (1 μM). Distilled water that dissolved AESP served as negative control. Results: As compared to negative control, AESP at 0.1, 1, and 10 mg/ml significantly relaxed aorta rings of WKY by 39.81 ± 2.99 % (P<0.001), 59.55 ± 7.60 % (P<0.001), and 72.58 ± 5.57 % (P<0.001), respectively. In SHR, AESP at 1 and 10 mg/ml significantly relaxed the aorta rings of SHR by 40.53 ± 3.66 % (P<0.001) and 65.73 ± 8.24 % (P<0.001), respectively. There was a significant difference between AESP-induced vasorelaxation in WKY and in SHR at a concentration of 0.1 mg/ml (P<0.001). The IC50 value for AESP-induced vasorelaxation on aorta rings of WKY (94.67 ± 1.41 μg/ml) was lower than of SHR (799.80 ± 1.69 μg/ml). Conclusions: The S. polyanthum leaves extract was able to cause significant relaxation on aorta rings of both normal and hypertensive rats. Thus, this finding is well-corroborated with the use of this plant as a traditional remedy for hypertension. It is suggested that an in-depth investigation of the mechanism of vasorelaxation of this plant is carried-out in the future. IIUM 2016-11-10 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/54723/1/poster%20presentation%20mrs.pdf application/pdf en http://irep.iium.edu.my/54723/2/front%20page%20abstract%20book.pdf application/pdf en http://irep.iium.edu.my/54723/3/List%20of%20Poster%20Presentation.pdf application/pdf en http://irep.iium.edu.my/54723/5/MRS2016-ABSTRACT-BOOK-102.pdf Ismail, Azlini and Wan Ahmad, Wan Amir Nizam (2016) Vasorelaxation effect of Syzygium polyanthum (wight) walp. Leaves extract on isolated thoracic aorta rings of normal and hypertensive rats. In: Medical Research Symposium & Pacific Partnership in conjunction with Kuantan Research Day 2016, 3-5 Aug 2016, Kuantan, Pahang. http://iiumedic.net/imjm/v1/vol-15-supplement-issue/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English English
topic	RM Therapeutics. Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics. Pharmacology RS Pharmacy and materia medica Ismail, Azlini Wan Ahmad, Wan Amir Nizam Vasorelaxation effect of Syzygium polyanthum (wight) walp. Leaves extract on isolated thoracic aorta rings of normal and hypertensive rats
description	Introduction: Syzygium polyanthum (Wight) Walp. leaves are traditionally consumed by the Malays as an alternative treatment for hypertension. Until now, effect of S. polyanthum leaves extract on blood vessel is not yet disclosed. Methods: This study investigated the effect of S. polyanthum leaves aqueous extract (AESP) (0.01, 0.1, 1 & 10 mg/ml) on isolated thoracic aorta rings of normotensive Wistar-Kyoto rats (WKY) and Spontaneously Hypertensive rats (SHR). Both rings were pre-contracted using phenylephrine (1 μM). Distilled water that dissolved AESP served as negative control. Results: As compared to negative control, AESP at 0.1, 1, and 10 mg/ml significantly relaxed aorta rings of WKY by 39.81 ± 2.99 % (P<0.001), 59.55 ± 7.60 % (P<0.001), and 72.58 ± 5.57 % (P<0.001), respectively. In SHR, AESP at 1 and 10 mg/ml significantly relaxed the aorta rings of SHR by 40.53 ± 3.66 % (P<0.001) and 65.73 ± 8.24 % (P<0.001), respectively. There was a significant difference between AESP-induced vasorelaxation in WKY and in SHR at a concentration of 0.1 mg/ml (P<0.001). The IC50 value for AESP-induced vasorelaxation on aorta rings of WKY (94.67 ± 1.41 μg/ml) was lower than of SHR (799.80 ± 1.69 μg/ml). Conclusions: The S. polyanthum leaves extract was able to cause significant relaxation on aorta rings of both normal and hypertensive rats. Thus, this finding is well-corroborated with the use of this plant as a traditional remedy for hypertension. It is suggested that an in-depth investigation of the mechanism of vasorelaxation of this plant is carried-out in the future.
format	Conference or Workshop Item
author	Ismail, Azlini Wan Ahmad, Wan Amir Nizam
author_facet	Ismail, Azlini Wan Ahmad, Wan Amir Nizam
author_sort	Ismail, Azlini
title	Vasorelaxation effect of Syzygium polyanthum (wight) walp. Leaves extract on isolated thoracic aorta rings of normal and hypertensive rats
title_short	Vasorelaxation effect of Syzygium polyanthum (wight) walp. Leaves extract on isolated thoracic aorta rings of normal and hypertensive rats
title_full	Vasorelaxation effect of Syzygium polyanthum (wight) walp. Leaves extract on isolated thoracic aorta rings of normal and hypertensive rats
title_fullStr	Vasorelaxation effect of Syzygium polyanthum (wight) walp. Leaves extract on isolated thoracic aorta rings of normal and hypertensive rats
title_full_unstemmed	Vasorelaxation effect of Syzygium polyanthum (wight) walp. Leaves extract on isolated thoracic aorta rings of normal and hypertensive rats
title_sort	vasorelaxation effect of syzygium polyanthum (wight) walp. leaves extract on isolated thoracic aorta rings of normal and hypertensive rats
publisher	IIUM
publishDate	2016
url	http://irep.iium.edu.my/54723/ http://irep.iium.edu.my/54723/ http://irep.iium.edu.my/54723/1/poster%20presentation%20mrs.pdf http://irep.iium.edu.my/54723/2/front%20page%20abstract%20book.pdf http://irep.iium.edu.my/54723/3/List%20of%20Poster%20Presentation.pdf http://irep.iium.edu.my/54723/5/MRS2016-ABSTRACT-BOOK-102.pdf
first_indexed	2023-09-18T21:17:23Z
last_indexed	2023-09-18T21:17:23Z
_version_	1777411653334204416

Vasorelaxation effect of Syzygium polyanthum (wight) walp. Leaves extract on isolated thoracic aorta rings of normal and hypertensive rats

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