Antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract

Antilipase from natural resources are a potential tool for the treatment of obesity while antioxidant-rich plants are essential in combating degenerative diseases. The aim of this study is to determine the antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract. The inhibitor...

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Main Authors:	Alias, Norsyuhada, Leow, Adam Thean Chor, Mohamad Ali, Mohd. Shukuri, Salleh, Abu Bakar, Ahmad Tajudin, Asilah, Raja Abd. Rahman, Raja Noor Zaliha
Format:	Conference or Workshop Item
Language:	English
Published:	Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2016
Subjects:	RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/54631/ http://irep.iium.edu.my/54631/ http://irep.iium.edu.my/54631/1/MRS%20for%20IREP.pdf

id	iium-54631
recordtype	eprints
spelling	iium-546312017-02-01T09:48:28Z http://irep.iium.edu.my/54631/ Antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract Alias, Norsyuhada Leow, Adam Thean Chor Mohamad Ali, Mohd. Shukuri Salleh, Abu Bakar Ahmad Tajudin, Asilah Raja Abd. Rahman, Raja Noor Zaliha RM Therapeutics. Pharmacology Antilipase from natural resources are a potential tool for the treatment of obesity while antioxidant-rich plants are essential in combating degenerative diseases. The aim of this study is to determine the antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract. The inhibitory activity against pancreatic lipase was determined by measuring the hydrolysis of p-nitrophenyl butyrate to p-nitrophenol at 405 nm. Antioxidant activity of O. stamineus extract was measured by 2, 2, diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity assay. The O. stamineus crude extract exhibited strong lipase inhibitory activity with an IC50 value of 34.7 µg/ml. The inhibition mode study disclosed that O. stamineus could act as uncompetitive inhibitor. O. stamineus showed high antioxidant activity with an EC50 value of 26.3 µg/ml. The results suggest that O. stamineus has shown potential as a source of natural antilipase and antioxidant. Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2016-12 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/54631/1/MRS%20for%20IREP.pdf Alias, Norsyuhada and Leow, Adam Thean Chor and Mohamad Ali, Mohd. Shukuri and Salleh, Abu Bakar and Ahmad Tajudin, Asilah and Raja Abd. Rahman, Raja Noor Zaliha (2016) Antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract. In: Medical Research Symposium & Pacific Partnership in conjunction with Kuantan Research Day 2016, 3rd-6th August 2016, Kuantan, Pahang. http://iiumedic.net/imjm/v1/download/Volume%2015%20Supplement/MRS2016-ABSTRACT-BOOK-50.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RM Therapeutics. Pharmacology
spellingShingle	RM Therapeutics. Pharmacology Alias, Norsyuhada Leow, Adam Thean Chor Mohamad Ali, Mohd. Shukuri Salleh, Abu Bakar Ahmad Tajudin, Asilah Raja Abd. Rahman, Raja Noor Zaliha Antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract
description	Antilipase from natural resources are a potential tool for the treatment of obesity while antioxidant-rich plants are essential in combating degenerative diseases. The aim of this study is to determine the antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract. The inhibitory activity against pancreatic lipase was determined by measuring the hydrolysis of p-nitrophenyl butyrate to p-nitrophenol at 405 nm. Antioxidant activity of O. stamineus extract was measured by 2, 2, diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity assay. The O. stamineus crude extract exhibited strong lipase inhibitory activity with an IC50 value of 34.7 µg/ml. The inhibition mode study disclosed that O. stamineus could act as uncompetitive inhibitor. O. stamineus showed high antioxidant activity with an EC50 value of 26.3 µg/ml. The results suggest that O. stamineus has shown potential as a source of natural antilipase and antioxidant.
format	Conference or Workshop Item
author	Alias, Norsyuhada Leow, Adam Thean Chor Mohamad Ali, Mohd. Shukuri Salleh, Abu Bakar Ahmad Tajudin, Asilah Raja Abd. Rahman, Raja Noor Zaliha
author_facet	Alias, Norsyuhada Leow, Adam Thean Chor Mohamad Ali, Mohd. Shukuri Salleh, Abu Bakar Ahmad Tajudin, Asilah Raja Abd. Rahman, Raja Noor Zaliha
author_sort	Alias, Norsyuhada
title	Antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract
title_short	Antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract
title_full	Antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract
title_fullStr	Antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract
title_full_unstemmed	Antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract
title_sort	antilipase and antioxidant activity of orthosiphon stamineus methanolic extract
publisher	Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia
publishDate	2016
url	http://irep.iium.edu.my/54631/ http://irep.iium.edu.my/54631/ http://irep.iium.edu.my/54631/1/MRS%20for%20IREP.pdf
first_indexed	2023-09-18T21:17:16Z
last_indexed	2023-09-18T21:17:16Z
_version_	1777411646501683200

Antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract

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