Additive electrospraying for scaffold functionalization

In the last decade, micro- and nanostructured platforms with interesting features as bioactive carriers have been fabricated by the deposition of electrospun fibers exhibiting extended surface area and high molecular permeability associated with fully interconnected pore architecture, thus creating...

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Main Authors:	Abdul Khodir, Wan Khartini, Altobelli, Rosaria, Guarino, Vincenzo, Ambrosio, Luigi
Format:	Book Chapter
Language:	English English
Published:	Elsevier Inc. 2018
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/54174/ http://irep.iium.edu.my/54174/ http://irep.iium.edu.my/54174/ http://irep.iium.edu.my/54174/2/54174_Additive%20electrospraying%20for%20scaffold%20functionalization_SCOPUS.pdf http://irep.iium.edu.my/54174/13/54174_Additive%20electrospraying%20for%20scaffold%20functionalization.pdf

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recordtype	eprints
spelling	iium-541742018-07-12T07:12:35Z http://irep.iium.edu.my/54174/ Additive electrospraying for scaffold functionalization Abdul Khodir, Wan Khartini Altobelli, Rosaria Guarino, Vincenzo Ambrosio, Luigi RS Pharmacy and materia medica In the last decade, micro- and nanostructured platforms with interesting features as bioactive carriers have been fabricated by the deposition of electrospun fibers exhibiting extended surface area and high molecular permeability associated with fully interconnected pore architecture, thus creating the opportunity to incorporate a wide range of actives/drugs for different use. In these systems, molecular release may occur via various molecular transport pathways, namely diffusion, desorption, and scaffold degradation, which may be tuned through a careful control of fiber morphology and composition. Recent studies have demonstrated that several shortcomings involve the possibility to incorporate bioactive species, not exposing molecules to fast and/or uncontrolled denaturation, thus preserving biochemical and biological fiber functionalities. In this context, additive electrospraying, namely the integration of electrosprayed nanoparticles into electrospun fiber network, is emerging as a really interesting route to control “separately” release and functional properties of the scaffolds in order to support cell activities by independent cues, during the tissue formation. Herein, we propose an overview of current progresses in the use of electrospraying and/or electrospinning for tissue engineering and molecular release. Our main objective is oriented to identify the most innovative integrated approaches recently optimized for scaffold functionalization to molecularly encode multicomponent platforms in order to obtain a spatial and time controlled release. Elsevier Inc. 2018-01-20 Book Chapter PeerReviewed application/pdf en http://irep.iium.edu.my/54174/2/54174_Additive%20electrospraying%20for%20scaffold%20functionalization_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/54174/13/54174_Additive%20electrospraying%20for%20scaffold%20functionalization.pdf Abdul Khodir, Wan Khartini and Altobelli, Rosaria and Guarino, Vincenzo and Ambrosio, Luigi (2018) Additive electrospraying for scaffold functionalization. In: Electrofluidodynamic Technologies (EFDTs) for Biomaterials and Medical Devices: Principles and Advances. Woodhead Publishing Series in Biomaterials . Elsevier Inc., pp. 179-203. ISBN 978-008101746-3 / 978-008101745-6 https://www.sciencedirect.com/science/article/pii/B9780081017456000104 10.1016/B978-0-08-101745-6.00010-4
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Abdul Khodir, Wan Khartini Altobelli, Rosaria Guarino, Vincenzo Ambrosio, Luigi Additive electrospraying for scaffold functionalization
description	In the last decade, micro- and nanostructured platforms with interesting features as bioactive carriers have been fabricated by the deposition of electrospun fibers exhibiting extended surface area and high molecular permeability associated with fully interconnected pore architecture, thus creating the opportunity to incorporate a wide range of actives/drugs for different use. In these systems, molecular release may occur via various molecular transport pathways, namely diffusion, desorption, and scaffold degradation, which may be tuned through a careful control of fiber morphology and composition. Recent studies have demonstrated that several shortcomings involve the possibility to incorporate bioactive species, not exposing molecules to fast and/or uncontrolled denaturation, thus preserving biochemical and biological fiber functionalities. In this context, additive electrospraying, namely the integration of electrosprayed nanoparticles into electrospun fiber network, is emerging as a really interesting route to control “separately” release and functional properties of the scaffolds in order to support cell activities by independent cues, during the tissue formation. Herein, we propose an overview of current progresses in the use of electrospraying and/or electrospinning for tissue engineering and molecular release. Our main objective is oriented to identify the most innovative integrated approaches recently optimized for scaffold functionalization to molecularly encode multicomponent platforms in order to obtain a spatial and time controlled release.
format	Book Chapter
author	Abdul Khodir, Wan Khartini Altobelli, Rosaria Guarino, Vincenzo Ambrosio, Luigi
author_facet	Abdul Khodir, Wan Khartini Altobelli, Rosaria Guarino, Vincenzo Ambrosio, Luigi
author_sort	Abdul Khodir, Wan Khartini
title	Additive electrospraying for scaffold functionalization
title_short	Additive electrospraying for scaffold functionalization
title_full	Additive electrospraying for scaffold functionalization
title_fullStr	Additive electrospraying for scaffold functionalization
title_full_unstemmed	Additive electrospraying for scaffold functionalization
title_sort	additive electrospraying for scaffold functionalization
publisher	Elsevier Inc.
publishDate	2018
url	http://irep.iium.edu.my/54174/ http://irep.iium.edu.my/54174/ http://irep.iium.edu.my/54174/ http://irep.iium.edu.my/54174/2/54174_Additive%20electrospraying%20for%20scaffold%20functionalization_SCOPUS.pdf http://irep.iium.edu.my/54174/13/54174_Additive%20electrospraying%20for%20scaffold%20functionalization.pdf
first_indexed	2023-09-18T21:16:39Z
last_indexed	2023-09-18T21:16:39Z
_version_	1777411607334223872

Additive electrospraying for scaffold functionalization

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