Organic arsenical exposures stimulates atheroscleorosis through oxidative stress increase and adhesion molecule expression

Organic arsenical exposures stimulates atheroscleorosis through oxidative stress increase and adhesion molecule expression

Approximately 100 million people are exposed to arsenic worldwide, majorly through drinking water and anthropogenic activities. Monosodium methylarsonate (MSMA) is a potent organoarsenical content of herbicides used in many Asian countries. Epidemiological studies have linked inorganic arsenic expo...

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Main Authors: Ishola, Afeez Adenkule, A Talib, Noorlelawati, Muhammad, Naznin, Buyong, Zunariah, Mohamed, Abdul Hadi, Myint, Yi Yi, Samsuddin, Niza, Abdul Ghani, Radiah, Abdullah, Norzamzila
Format: Article
Language:English
English
Published: World association of Medical Editors 2016
Subjects:
RB Pathology
RM283 Endocrinotheraphy
Online Access:http://irep.iium.edu.my/53867/
http://irep.iium.edu.my/53867/
http://irep.iium.edu.my/53867/
http://irep.iium.edu.my/53867/1/JAPS_53867.pdf
http://irep.iium.edu.my/53867/7/53867_Organic%20arsenical%20exposures%20stimulat_SCOPUS.pdf
id iium-53867
recordtype eprints
spelling iium-538672017-05-30T04:27:52Z http://irep.iium.edu.my/53867/ Organic arsenical exposures stimulates atheroscleorosis through oxidative stress increase and adhesion molecule expression Ishola, Afeez Adenkule A Talib, Noorlelawati Muhammad, Naznin Buyong, Zunariah Mohamed, Abdul Hadi Myint, Yi Yi Samsuddin, Niza Abdul Ghani, Radiah Abdullah, Norzamzila RB Pathology RM283 Endocrinotheraphy Approximately 100 million people are exposed to arsenic worldwide, majorly through drinking water and anthropogenic activities. Monosodium methylarsonate (MSMA) is a potent organoarsenical content of herbicides used in many Asian countries. Epidemiological studies have linked inorganic arsenic exposure with atherosclerosis, whereas organoarsenicals toxicological studies are scanty. Paraoxonase 1 (PON1) enzyme suppresses systemic Ox-LDL generation, thereby preventing atherosclerosis. We investigated effects of MSMA oral exposure on PON1, lipid peroxidation and atherosclerosis development. Five groups (n=11) of Sprague- Dawley rats received daily intubation of MSMA at 0 (control), 42.1, 63.2, 126.4 and 210.7 mg/kg BW respectively for 16 weeks. Serum samples were analysed for PON1 activities, Ox-LDL and MDA levels. Histomorphometric evaluation (H&E and VVG) and immunohistochemistry (VCAM-1 and ICAM-1) were done on aorta. High mortality rate led to discontinuation of 126.4 and 210.7 mg/kg BW treatment groups. Groups treated with 42.1 and 63.2 mg/kg B.W. MSMA had a significantly higher MDA (p=0.004,CI: 2.73-0.82) and Ox-LDL (p<0.0001,CI: 2425.07-955.45) levels but lower PON1:Ox-LDLratio (p<0.0001,CI: 0.49-1.07) compared to control. Microscopically, treatment groups showed early atherosclerotic intima thickening and positive VCAM-1 and ICAM-1 expressions. In conclusion, chronic MSMA exposure reduced PON1 ability to hydrolyse Ox-LDL and also induced inflammation by elevating oxidative stress that supports early atherosclerosis development. World association of Medical Editors 2016-11-19 Article PeerReviewed application/pdf en http://irep.iium.edu.my/53867/1/JAPS_53867.pdf application/pdf en http://irep.iium.edu.my/53867/7/53867_Organic%20arsenical%20exposures%20stimulat_SCOPUS.pdf Ishola, Afeez Adenkule and A Talib, Noorlelawati and Muhammad, Naznin and Buyong, Zunariah and Mohamed, Abdul Hadi and Myint, Yi Yi and Samsuddin, Niza and Abdul Ghani, Radiah and Abdullah, Norzamzila (2016) Organic arsenical exposures stimulates atheroscleorosis through oxidative stress increase and adhesion molecule expression. Journal of Applied Pharmaceutical Science, 6 (11). 040-051. ISSN 2231-3354 http://www.japsonline.com/admin/php/uploads/2047_pdf.pdf 10.7324/JAPS.2016.601107
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
English
topic RB Pathology
RM283 Endocrinotheraphy
spellingShingle RB Pathology
RM283 Endocrinotheraphy
Ishola, Afeez Adenkule
A Talib, Noorlelawati
Muhammad, Naznin
Buyong, Zunariah
Mohamed, Abdul Hadi
Myint, Yi Yi
Samsuddin, Niza
Abdul Ghani, Radiah
Abdullah, Norzamzila
Organic arsenical exposures stimulates atheroscleorosis through oxidative stress increase and adhesion molecule expression
description Approximately 100 million people are exposed to arsenic worldwide, majorly through drinking water and anthropogenic activities. Monosodium methylarsonate (MSMA) is a potent organoarsenical content of herbicides used in many Asian countries. Epidemiological studies have linked inorganic arsenic exposure with atherosclerosis, whereas organoarsenicals toxicological studies are scanty. Paraoxonase 1 (PON1) enzyme suppresses systemic Ox-LDL generation, thereby preventing atherosclerosis. We investigated effects of MSMA oral exposure on PON1, lipid peroxidation and atherosclerosis development. Five groups (n=11) of Sprague- Dawley rats received daily intubation of MSMA at 0 (control), 42.1, 63.2, 126.4 and 210.7 mg/kg BW respectively for 16 weeks. Serum samples were analysed for PON1 activities, Ox-LDL and MDA levels. Histomorphometric evaluation (H&E and VVG) and immunohistochemistry (VCAM-1 and ICAM-1) were done on aorta. High mortality rate led to discontinuation of 126.4 and 210.7 mg/kg BW treatment groups. Groups treated with 42.1 and 63.2 mg/kg B.W. MSMA had a significantly higher MDA (p=0.004,CI: 2.73-0.82) and Ox-LDL (p<0.0001,CI: 2425.07-955.45) levels but lower PON1:Ox-LDLratio (p<0.0001,CI: 0.49-1.07) compared to control. Microscopically, treatment groups showed early atherosclerotic intima thickening and positive VCAM-1 and ICAM-1 expressions. In conclusion, chronic MSMA exposure reduced PON1 ability to hydrolyse Ox-LDL and also induced inflammation by elevating oxidative stress that supports early atherosclerosis development.
format Article
author Ishola, Afeez Adenkule
A Talib, Noorlelawati
Muhammad, Naznin
Buyong, Zunariah
Mohamed, Abdul Hadi
Myint, Yi Yi
Samsuddin, Niza
Abdul Ghani, Radiah
Abdullah, Norzamzila
author_facet Ishola, Afeez Adenkule
A Talib, Noorlelawati
Muhammad, Naznin
Buyong, Zunariah
Mohamed, Abdul Hadi
Myint, Yi Yi
Samsuddin, Niza
Abdul Ghani, Radiah
Abdullah, Norzamzila
author_sort Ishola, Afeez Adenkule
title Organic arsenical exposures stimulates atheroscleorosis through oxidative stress increase and adhesion molecule expression
title_short Organic arsenical exposures stimulates atheroscleorosis through oxidative stress increase and adhesion molecule expression
title_full Organic arsenical exposures stimulates atheroscleorosis through oxidative stress increase and adhesion molecule expression
title_fullStr Organic arsenical exposures stimulates atheroscleorosis through oxidative stress increase and adhesion molecule expression
title_full_unstemmed Organic arsenical exposures stimulates atheroscleorosis through oxidative stress increase and adhesion molecule expression
title_sort organic arsenical exposures stimulates atheroscleorosis through oxidative stress increase and adhesion molecule expression
publisher World association of Medical Editors
publishDate 2016
url http://irep.iium.edu.my/53867/
http://irep.iium.edu.my/53867/
http://irep.iium.edu.my/53867/
http://irep.iium.edu.my/53867/1/JAPS_53867.pdf
http://irep.iium.edu.my/53867/7/53867_Organic%20arsenical%20exposures%20stimulat_SCOPUS.pdf
first_indexed 2023-09-18T21:16:12Z
last_indexed 2023-09-18T21:16:12Z
_version_ 1777411578542424064

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